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Inhaled Doxorubicin in Treating Patients With Advanced Solid Tumors Affecting the Lungs

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00020124
Recruitment Status : Completed
First Posted : January 27, 2003
Last Update Posted : March 15, 2012
National Cancer Institute (NCI)
Information provided by:
National Institutes of Health Clinical Center (CC)

Brief Summary:

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving drugs in different ways may kill more tumor cells.

PURPOSE: Phase I trial to study the effectiveness of inhaled doxorubicin in treating patients who have advanced solid tumors affecting the lungs.

Condition or disease Intervention/treatment Phase
Lung Cancer Malignant Mesothelioma Metastatic Cancer Drug: doxorubicin hydrochloride Phase 1

Detailed Description:


  • Determine the maximum tolerated dose and phase II dose of inhaled doxorubicin in patients with advanced solid tumors affecting the lungs.
  • Determine the toxicity of this regimen in these patients.
  • Determine the pharmacokinetic profile of inhaled doxorubicin in blood in these patients.
  • Determine the relationship between pharmacodynamic parameters and toxic effects of this regimen in these patients.

OUTLINE: This is a dose-escalation study.

Patients receive inhaled doxorubicin every 3 weeks for up to 3 doses. Patients with stable or responding disease may receive additional doses in the absence of disease progression or unacceptable toxicity.

Cohorts of 3-6 patients receive escalating doses of doxorubicin until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity.

Patients are followed at 3 weeks and 3 months.

PROJECTED ACCRUAL: Approximately 33 patients will be accrued for this study within 18-24 months.

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Study Type : Interventional  (Clinical Trial)
Primary Purpose: Treatment
Official Title: Phase I and Clinical Pharmacologic Study of Inhaled Doxorubicin in Adults With Advanced Solid Tumors Affecting the Lungs
Study Start Date : June 2000
Actual Study Completion Date : December 2002

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No


  • Histologically proven advanced cancer not curable by standard chemotherapy, radiotherapy, or surgery

    • Clinical evidence of primary lung or tracheal cancer OR
    • Metastatic cancer to the lung
  • Extrathoracic metastases eligible if following criteria are met:

    • Sites are stable
    • Pulmonary sites are primary life-threatening sites
    • Evidence that study treatment may benefit the patient
  • Measurable or evaluable disease
  • No germ cell tumor, leukemia, or lymphoma involving the lungs that is treatable with systemic agents
  • No complete atelectasis due to high-grade airway obstruction



  • 18 and over

Performance status:

  • ECOG 0-1

Life expectancy:

  • More than 3 months


  • Absolute neutrophil count at least 1,500/mm^3
  • Platelet count at least 100,000/mm^3
  • Hemoglobin at least 10 g/dL


  • Bilirubin no greater than 1.0 mg/dL
  • AST and ALT less than 1.5 times upper limit of normal


  • Creatinine no greater than 1.6 mg/dL OR
  • Creatinine clearance at least 60 mL/min


  • LVEF at least 40% by MUGA scan or echocardiogram
  • No unstable angina, congestive heart failure, or symptomatic arrhythmias


  • DLCO at least 50% predicted
  • FVC and FEV1 at least 50% predicted
  • Resting oxygen saturation at least 90%
  • Exercise oxygen saturation at least 85%
  • Oxygen consumption greater than 50% predicted
  • No prior radiation pneumonitis
  • No asthma
  • No radiation-induced pulmonary damage


  • No hypersensitivity to doxorubicin
  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile patients must use effective contraception during and for 6 months after study
  • HIV negative
  • No congenital problems (e.g., cleft palate) or other anomalies that prevent tight fit of a mouthseal


Biologic therapy:

  • At least 4 weeks since prior biologic therapy and recovered
  • No prior trastuzumab (Herceptin)


  • See Disease Characteristics
  • At least 4 weeks since prior chemotherapy and recovered
  • Prior doxorubicin allowed if LVEF at least 40% by MUGA scan or echocardiogram
  • No prior mitomycin, bleomycin, or nitrosoureas
  • No other concurrent systemic chemotherapy

Endocrine therapy:

  • Not specified


  • See Disease Characteristics
  • At least 4 weeks since prior radiotherapy and recovered
  • At least 12 months since prior radiotherapy to chest
  • No prior radiotherapy to more than 20% of total lung volume
  • Prior chest wall or primary breast radiotherapy allowed
  • Prior radioactive iodine allowed
  • No concurrent thoracic radiotherapy


  • See Disease Characteristics
  • No prior total pneumonectomy


  • No other concurrent experimental drug

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00020124

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United States, Maryland
Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support
Bethesda, Maryland, United States, 20892-1182
Sponsors and Collaborators
National Institutes of Health Clinical Center (CC)
National Cancer Institute (NCI)
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Study Chair: David S. Schrump, MD NCI - Surgery Branch
Layout table for additonal information Identifier: NCT00020124    
Obsolete Identifiers: NCT00004636
Other Study ID Numbers: 000088
First Posted: January 27, 2003    Key Record Dates
Last Update Posted: March 15, 2012
Last Verified: March 2012
Keywords provided by National Institutes of Health Clinical Center (CC):
recurrent non-small cell lung cancer
extensive stage small cell lung cancer
recurrent small cell lung cancer
advanced malignant mesothelioma
recurrent malignant mesothelioma
stage IIIB non-small cell lung cancer
stage IV non-small cell lung cancer
pulmonary carcinoid tumor
lung metastases
Additional relevant MeSH terms:
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Lung Neoplasms
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Lung Diseases
Respiratory Tract Diseases
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms, Mesothelial
Liposomal doxorubicin
Antibiotics, Antineoplastic
Antineoplastic Agents
Topoisomerase II Inhibitors
Topoisomerase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action