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Hyperapo B and Coronary Heart Disease

This study has been completed.
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI) Identifier:
First received: May 25, 2000
Last updated: June 23, 2005
Last verified: May 2000

To determine the role of apolipoprotein B and apolipoprotein A1 in the etiology of coronary artery disease.

Cardiovascular Diseases
Coronary Disease
Heart Diseases
Diabetes Mellitus
Hypercholesterolemia, Familial

Study Type: Observational

Resource links provided by NLM:

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date: August 1984
Estimated Study Completion Date: December 1991
Detailed Description:


Hyperapo B is a phenotype defined as elevated plasma level of the major apoprotein B of low density lipoproteins in the presence of a normal plasma level of low density lipoprotein cholesterol. It has been demonstrated that hyperapo B is strongly associated with coronary artery disease. In 1984 when the study began, the independence of this association with other risk factors for coronary artery disease such as cigarette smoking, hypertension, and low plasma levels of high density lipoproteins was not known. The study improved knowledge of the pathophysiology of coronary artery disease and of the genetic and biochemical defects of hyperapo B and hypoalphalipoproteinemia.


Interviews were conducted and clinical data collected on each index case and spouse, as well as on first degree relatives. Risk factor data included blood pressure, blood lipid levels, obesity, cigarette smoking, fasting blood sugar and diabetes, hormone use and menopause for women, physical activity, personality scores, and family history. Clinical data included the indications for coronary arteriography, history of use of lipid-lowering agents and insulin, presence of corneal arcus, xanthomata, and xanthelasma, and the electrocardiogram.

To determine if the apolipoprotein B gene and the apolipoprotein A1-C3-A4 gene cluster were independent predictors of premature coronary disease, the relation between DNA polymeric sites within the two genes and coronary disease were investigated using cloned DNA fragments as molecular probes. To determine if apolipoprotein B and apolipoprotein A levels aggregated in families and to determine if hyperapo B and hypoalphalipoproteinemia segregated as Mendelian traits, genetic analysis was conducted in the 200 index cases and the 900 first degree relatives. Studies were also conducted on the linkages between hyperapo B and haplotypes of the apolipoprotein B gene, on hyperapo B and the Ag polymorphisms, and on hyperalphalipoproteinemia and haplotypes of the apolipoprotein A1-C3-A4 gene cluster.


Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No

No eligibility criteria

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No Contacts or Locations Provided
  More Information

Kwiterovich PO Jr, Beaty T, Bachorik P, Chen J, Franklin F, Georgopoulos L, and Sniderman A: Pediatric Hyperlipoproteinemia: The Phenotypic Expression of Hyperapobetalipoproteinemia in Young Probands and Their Parents (Naito H, Widhalm K, Eds.) Alan Liss, Inc. in press, 1987
Sniderman A, Kwiterovich PO Jr: Hyperapobetalipoproteinemia and LDL and HDL2 Heterogenity. Proceedings of the Workshop on Lipoprotein Heterogeneity, U.S. Department of Health and Human Services, NIH Publication No. 87-2646, pp 293-304, 1987 Identifier: NCT00005168     History of Changes
Other Study ID Numbers: 1042
Study First Received: May 25, 2000
Last Updated: June 23, 2005
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Cardiovascular Diseases
Coronary Artery Disease
Coronary Disease
Diabetes Mellitus
Heart Diseases
Hyperlipoproteinemia Type II
Arterial Occlusive Diseases
Endocrine System Diseases
Genetic Diseases, Inborn
Glucose Metabolism Disorders
Lipid Metabolism Disorders
Lipid Metabolism, Inborn Errors
Metabolic Diseases
Metabolism, Inborn Errors
Myocardial Ischemia
Vascular Diseases processed this record on February 25, 2015