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Randomized Study of the Effects of Glucose on Cognition in Healthy Young and Elderly People and Parkinson's Disease Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00004451
Recruitment Status : Completed
First Posted : October 19, 1999
Last Update Posted : December 1, 2005
University of Virginia
Information provided by:
National Institute of Mental Health (NIMH)

Brief Summary:
This study will determine whether glucose facilitates memory in healthy elderly people and those with Parkinson's disease.

Condition or disease Intervention/treatment Phase
Parkinson Disease Drug: Glucose Not Applicable

Detailed Description:
Subjects fast for 8 hours before receiving a test to determine their blood glucose levels. Following this test, subjects are randomized to receive either a glucose or saccharin sweetened drink. A series of memory tests and an additional 3 blood glucose level tests are administered approximately 15 minutes later. A minimum of 1 week afterward, the subjects return and receive the alternate sweetener followed by additional memory tests.

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Study Type : Interventional  (Clinical Trial)
Enrollment : 120 participants
Allocation: Randomized
Masking: Double
Primary Purpose: Treatment
Study Start Date : March 1998

Resource links provided by the National Library of Medicine

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Three groups of subjects are eligible for this study: Healthy young adults between ages 18 and 30; Healthy elderly adults between ages 60 and 90; AND Anyone diagnosed with Parkinson's disease

Exclusion Criteria:

  • Prior surgery to remove part of the stomach
  • Diabetes, Addison's, or Cushing's diseases

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00004451

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United States, Virginia
University of Virginia
Charlottesville, Virginia, United States, 22908
Sponsors and Collaborators
National Institute of Mental Health (NIMH)
University of Virginia
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Study Chair: Carol A. Manning University of Virginia
Layout table for additonal information Identifier: NCT00004451    
Other Study ID Numbers: 199/13548
K07MH001197 ( U.S. NIH Grant/Contract )
First Posted: October 19, 1999    Key Record Dates
Last Update Posted: December 1, 2005
Last Verified: November 2005
Keywords provided by National Institute of Mental Health (NIMH):
Parkinson disease
neurologic and psychiatric disorders
rare disease
Additional relevant MeSH terms:
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Parkinson Disease
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Movement Disorders
Neurodegenerative Diseases