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Study of Prevalence and Clinical Phenotype in Patients With Glucocorticoid-Remediable Aldosteronism

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00004354
Recruitment Status : Completed
First Posted : October 19, 1999
Last Update Posted : June 24, 2005
Brigham and Women's Hospital
Information provided by:
National Center for Research Resources (NCRR)

Brief Summary:

OBJECTIVES: I. Determine the prevalence of glucocorticoid-remediable aldosteronism (GRA) in various hypertensive populations and screen at risk members of GRA pedigrees.

II. Investigate other factors regulating blood pressure in GRA (environmental, genetically determined factors).

III. Investigate renal and hormonal mechanisms regulating potassium homeostasis in GRA.

IV. Describe clinical phenotype of GRA patients. V. Prospectively screen GRA-affected patients with MRI angiography for intracranial aneurysm.

Condition or disease

Detailed Description:


Patients are screened for high blood pressure, suppressed plasma renin activity level, and low potassium levels. Urine is collected for a 24 hour period. Blood specimen is collected for molecular biologic evaluation for the presence of the chimeric gene diagnostic of GRA. Any history of cardiovascular events is recorded.

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Study Type : Observational
Study Start Date : June 1999

Resource links provided by the National Library of Medicine

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No


--Disease Characteristics-- Diagnosed glucocorticoid-remediable aldosteronism (GRA) with hypertension Hypokalemia is variably seen Blood pressure variably elevated Elevated level of aldosterone Low level of plasma renin activity

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00004354

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United States, Massachusetts
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Sponsors and Collaborators
National Center for Research Resources (NCRR)
Brigham and Women's Hospital
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Study Chair: Robert G. Dluhy Brigham and Women's Hospital
Layout table for additonal information Identifier: NCT00004354    
Other Study ID Numbers: 199/11917
First Posted: October 19, 1999    Key Record Dates
Last Update Posted: June 24, 2005
Last Verified: May 2002
Keywords provided by National Center for Research Resources (NCRR):
endocrine disorders
genetic diseases and dysmorphic syndromes
rare disease
Additional relevant MeSH terms:
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Adrenocortical Hyperfunction
Adrenal Gland Diseases
Endocrine System Diseases