Investigation of the Human Immune Response in Normal Subjects and Patients With Disorders of the Immune System and Cancer
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|ClinicalTrials.gov Identifier: NCT00001582|
Recruitment Status : Recruiting
First Posted : November 4, 1999
Last Update Posted : January 10, 2018
|Condition or disease|
|T-cell Lymphoma B-Cell Lymphoma ATL Myeloma|
- The evaluation of the cells of the immune system and HTLV-1 infection have been a central focus of the Metabolism Branch for the past 30 years.
- Blood obtained by apheresis or blood drawing, skin biopsies and other tissues will be evaluated for abnormalities related to immunity, HTLV-1 infection and the immune system.
- Advances in the characterization of acquired genetic changes in tumor samples has
led to insights for the development of targeted therapy of malignancy
- To characterize the molecular biology and immunological features as well as the clinical course of individuals with suspected or known disorders of the immune system or cancer.
- To define the nature of the immunological, genetic and epigenetic abnormalities in the cells of patients with immunodeficiency diseases associated with infections and/or a high incidence of malignancy and in patients with cancer.
- To obtain whole blood, plasma, and leukocytes, as well as skin, lymph node and bone marrow biopsies on patients with immunodeficiency or cancer to investigate the immune system.
- Subjects with cancer.
- Subjects with immunodeficiency.
- Subjects with HTLV-1 infection.
-This is a natural history study that permits tissue acquisition for analysis of the immune system and HTLV-1 infection.
|Study Type :||Observational|
|Estimated Enrollment :||1000 participants|
|Official Title:||Collection of Blood, Bone Marrow and Tissue Samples for the Investigation of the Human Immune Response, Lymphoma Biology and HTLV-1 Infection|
|Study Start Date :||July 10, 1997|
- Create Biobank [ Time Frame: Ongoing ]No statistical endpoints are identified for this study; the purpose of the study is to acquire information regarding various immunodeficiency syndromes, HTLV-1 infection and malignancies. The data collected will not be combined for a summary report of the entire study; however, reports for specific disease entities may be published.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00001582
|Contact: Maureen E Edgerly, R.N.||(240) firstname.lastname@example.org|
|Contact: Thomas A Waldmann, M.D.||(240) email@example.com|
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Recruiting|
|Bethesda, Maryland, United States, 20892|
|Contact: For more information at the NIH Clinical Center contact National Cancer Institute Referral Office (888) NCI-1937|
|Principal Investigator:||Thomas A Waldmann, M.D.||National Cancer Institute (NCI)|