Evaluation of the Genetics of Bipolar Disorder
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|ClinicalTrials.gov Identifier: NCT00001174|
Recruitment Status : Recruiting
First Posted : November 4, 1999
Last Update Posted : May 26, 2023
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|Condition or disease|
Bipolar affective disorder is a severe, heritable condition affecting about one percent of
the population. The mode of inheritance is poorly understood and probably involves multiple loci of small to moderate effect. In this project, we use genetic mapping and sequencing methods to identify genetic markers and variations that contribute to the risk of bipolar disorder. Individuals diagnosed with bipolar disorder are studied, along with their relatives. Phenotypic information obtained from clinical interviews and family history is correlated with genotypic information obtained from genetic marker and sequencing methods. The goal is to identify genes involved in bipolar disorder and related conditions so that better methods of diagnosis, treatment, and prevention can be developed.
|Study Type :||Observational|
|Estimated Enrollment :||6000 participants|
|Official Title:||Bipolar Genetics: A Collaborative Study|
|Actual Study Start Date :||August 11, 1994|
Patients with bipolar disorder
- Diagnosis of bipolar disorder or related mental illness by direct interview [ Time Frame: Diagnosis is established primarily at the initial study visit. Participants who consent to recontact are re-evaluated when they or family informants report events that could lead to a revised diagnosis. ]Psychiatric diagnosis is based on systematic review of established signs and symptoms, using an instrument designed to elicit retrospective information of known reliability, supplemented with information from family informants, any medical records, and by dimensional symptom measures.
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|Ages Eligible for Study:||18 Years and older (Adult, Older Adult)|
|Sexes Eligible for Study:||All|
|Accepts Healthy Volunteers:||Yes|
|Sampling Method:||Non-Probability Sample|
- INCLUSION CRITERIA:
Age > 18 yr
Able to provide informed consent
Bipolar disorder or related conditions not attributable to substance abuse, neurological disease; or a 1st or 2nd degree relative of an enrolled participant. Related conditions are defined as those found more often among relatives of people with bipolar disorder or which have been shown to be genetically correlated with bipolar disorder through molecular genetic studies. These include major depression, schizophrenia, panic disorder, and attention deficit hyperactivity disorder.
Able to safely provide a blood or saliva sample
Active alcohol or substance abuse.
NIMH employees/staff and their immediate family members will be excluded from the study per NIMH policy.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00001174
|Contact: Emily Besancon||(866) firstname.lastname@example.org|
|Contact: Francis J McMahon, M.D.||(301) email@example.com|
|United States, Maryland|
|National Institutes of Health Clinical Center||Recruiting|
|Bethesda, Maryland, United States, 20892|
|Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY dial 711 firstname.lastname@example.org|
|Principal Investigator:||Francis J McMahon, M.D.||National Institute of Mental Health (NIMH)|
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:||National Institute of Mental Health (NIMH)|
|Other Study ID Numbers:||
|First Posted:||November 4, 1999 Key Record Dates|
|Last Update Posted:||May 26, 2023|
|Last Verified:||January 12, 2023|
|Studies a U.S. FDA-regulated Drug Product:||No|
|Studies a U.S. FDA-regulated Device Product:||No|
Bipolar and Related Disorders