Assessment of Patients With Multiple Sclerosis (MS)
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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT00001156 |
Recruitment Status :
Completed
First Posted : November 4, 1999
Last Update Posted : July 2, 2017
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Multiple sclerosis (MS) is a disease of the nervous system. The exact cause of MS is unknown, but it is believed to be an autoimmune condition. Autoimmune conditions are diseases that cause the body's immune system and natural defenses to attack healthy cells. In the case of MS, the immune system begins attacking myelin, the cells that make up the sheath covering nerves. Without myelin, nerves are unable to transmit signals effectively and symptoms occur.
This study is directed toward a better understanding of the cause of Multiple Sclerosis (MS). Researchers will evaluate patients with a tentative diagnosis of MS or other neurological diseases possibly caused by a immunological reaction. Patients will undergo a series of three MRIs, taken once a month for three months and submit blood samples for immunological studies.
Condition or disease |
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Herpesviridae Infection HTLV-I Infection Multiple Sclerosis Tropical Spastic Paraparesis Vasculitis |
Study Type : | Observational |
Actual Enrollment : | 1388 participants |
Official Title: | Combined Clinical, Immunological and Virological Assessment of Patients With Multiple Sclerosis (MS) |
Study Start Date : | January 23, 1976 |
Study Completion Date : | February 1, 2010 |


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Ages Eligible for Study: | 18 Years to 75 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
- INCLUSION CRITERIA:
Diagnosis of possible MS.
Age between 18 and 75.
EXCLUSION CRITERIA:
Clinically significant medical condition other than MS that could cause neurological dysfunction.
Currently enrolled in an experimental study.
Medical contraindication for MRI.
Psychological contraindications for MRI.
Unable to provide informed consent.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00001156
United States, Maryland | |
National Institutes of Health Clinical Center, 9000 Rockville Pike | |
Bethesda, Maryland, United States, 20892 |
ClinicalTrials.gov Identifier: | NCT00001156 |
Other Study ID Numbers: |
760021 76-N-0021 |
First Posted: | November 4, 1999 Key Record Dates |
Last Update Posted: | July 2, 2017 |
Last Verified: | February 1, 2010 |
Immunogenetics Tropical Spastic Paraplegia Twins Epstein-Barr Virus HTLV-I |
Vasculitis Cerebrospinal Fluid Immunity to Viruses Multiple Sclerosis Magnetic Resonance Imaging |
Infection Communicable Diseases Paraparesis, Tropical Spastic HTLV-I Infections Herpesviridae Infections Muscle Spasticity Multiple Sclerosis Paraparesis Paraparesis, Spastic Vasculitis Sclerosis Pathologic Processes Demyelinating Autoimmune Diseases, CNS Autoimmune Diseases of the Nervous System Nervous System Diseases |
Demyelinating Diseases Autoimmune Diseases Immune System Diseases Vascular Diseases Cardiovascular Diseases Muscular Diseases Musculoskeletal Diseases Muscle Hypertonia Neuromuscular Manifestations Neurologic Manifestations Paresis Deltaretrovirus Infections Retroviridae Infections RNA Virus Infections Virus Diseases |