| 1 |
NCT03259685 |
Not yet recruiting |
Effect of Non-nutritive Sweeteners of High Sugar Sweetened Beverages on Metabolic Health and Gut Microbiome |
- Gut Microbiota
- Metabolic Syndrome
|
- Other: 710 ml of regular soft drinks, taken daily for 10 weeks
- Other: 710 ml of diet soft drinks, taken daily for 10 weeks
- Other: 710 ml of stevia-sweetened soft drinks, taken daily for 10 weeks
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Prevention
|
- Changes in metabolic syndrome parameters including insulin/glucose homeostasis and lipid/lipoprotein metabolism in sugar-sweetened beverages (SSB) consumers following regular, diet or stevia-sweetened beverages intakes for 10 weeks.
- Changes in intestinal homeostasis of SSB consumers following regular, diet or stevia-sweetened beverages intakes for 10 weeks.
- Changes in gut microbiota composition of SSB consumers following regular, diet or stevia-sweetened beverages intakes for 10 weeks.
|
66 |
All |
18 Years to 55 Years (Adult) |
NCT03259685 |
SBG 2017-136 |
|
September 2017 |
December 2019 |
December 2020 |
August 24, 2017 |
August 25, 2017 |
|
|
|
| 2 |
NCT03125356 |
Recruiting |
Low-calorie Sweeteners and Adipose Signaling |
- Nutritional and Metabolic Diseases
|
|
Interventional
|
Not Applicable |
- George Washington University
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
|
30 |
Female |
18 Years to 25 Years (Adult) |
NCT03125356 |
111635 |
|
January 1, 2017 |
December 31, 2018 |
December 31, 2018 |
April 24, 2017 |
April 24, 2017 |
|
- Milken Institute School of Public Health and GW Medical Faculty Associates
Washington, D.C., District of Columbia, United States
|
|
| 3 |
NCT02890108 |
Recruiting |
Effect of Consumption of Non Caloric Sweeteners and Insulin Sensibility |
|
- Dietary Supplement: Sugar sweetened beverages
- Dietary Supplement: Artificially sweetened beverages
|
Interventional
|
Not Applicable |
- Instituto de Nutrición y Tecnología de los Alimentos
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Prevention
|
- Insulin sensibility
- Glycemic response
|
10 |
All |
25 Years to 45 Years (Adult) |
NCT02890108 |
EANC-1 |
|
August 2016 |
September 2016 |
October 2016 |
September 7, 2016 |
September 7, 2016 |
|
- Institute of Nutrition and Tecnology of Food, University of Chile
Santiago, Metropolitan region, Chile
|
|
| 4 |
NCT02487537 |
Recruiting |
Immediate and Long-term Induction of Incretin Release by Artificial Sweeteners 2 |
|
- Dietary Supplement: custom-made soft drink
|
Interventional
|
Not Applicable |
- German Institute of Human Nutrition
- Ludwig-Maximilians - University of Munich
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
|
- change in release of GIP
- change in release of GLP-1
- change in release of GLP-2
- (and 4 more...)
|
16 |
Male |
18 Years to 50 Years (Adult) |
NCT02487537 |
ILIAS-2 |
ILIAS-2 |
March 2015 |
June 2016 |
December 2016 |
July 1, 2015 |
November 22, 2016 |
|
- German Institut for Human Nutrition; Department for Clinical Nutrition
Nuthetal, Brandenburg, Germany
|
|
| 5 |
NCT01200940 |
Recruiting |
Metabolic Effects of Non-Nutritive Sweeteners |
|
- Other: Sucralose
- Other: Aspartame
- Other: Acesulfame-Potassium
|
Interventional
|
Phase 1
Phase 2 |
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- GLP-1 secretion change with sucralose
- Change in gastric emptying
- Dose based change to GLP-1 secretion
- Change in satiety
|
250 |
All |
6 Years and older (Child, Adult, Older Adult) |
NCT01200940 |
100163
10-DK-0163 |
|
July 1, 2010 |
June 30, 2020 |
June 30, 2020 |
September 14, 2010 |
May 9, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 6 |
NCT02459535 |
Recruiting |
Immediate and Long-term Induction of Incretin Release by Artificial Sweeteners 1 |
|
- Other: oral stimulation glucose
- Other: oral stimulation saccharin
- Other: oral stimulation aspartame
- Other: oral stimulation sucralose
|
Interventional
|
Not Applicable |
- German Institute of Human Nutrition
- Ludwig-Maximilians - University of Munich
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- change in GIP release
- change in GLP-1 release
- change in GLP-2 release
- (and 4 more...)
|
16 |
Male |
18 Years to 50 Years (Adult) |
NCT02459535 |
ILIAS-1 |
ILIAS-1 |
March 2015 |
June 2016 |
December 2016 |
June 2, 2015 |
November 22, 2016 |
|
- German Institut for Human Nutrition; Department for Clinical Nutrition
Nuthetal, Brandenburg, Germany
|
|
| 7 |
NCT02821923 |
Recruiting |
Effect of the Natural Sweeteners Erythritol and Xylitol on Vascular Function in Obese Volunteers |
|
- Dietary Supplement: E967-Xylitol
- Dietary Supplement: E968-Erythritol
|
Interventional
|
Not Applicable |
- University Hospital, Basel, Switzerland
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Basic Science
|
- Central arterial stiffness measured by sonography
- Glucose tolerance measured by oral glucose tolerance test
|
45 |
All |
18 Years to 55 Years (Adult) |
NCT02821923 |
Poly Vasc |
|
June 2016 |
June 2018 |
June 2018 |
July 4, 2016 |
September 18, 2017 |
|
- University Hospital
Basel, Switzerland
|
|
| 8 |
NCT02824614 |
Recruiting |
Effect of the Natural Sweeteners Erythritol and Xylitol on Gut Microbiota and Glucose Metabolism in Obese Volunteers |
|
- Dietary Supplement: E967-Xylitol
- Dietary Supplement: E968-Erythritol
|
Interventional
|
Not Applicable |
- University Hospital, Basel, Switzerland
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Basic Science
|
- Glucose tolerance measured with oral glucose tolerance test
- Human gut microbiota composition measured with metagenomic shotgun sequencing
- Gut microbial-related metabolites in feces
- (and 2 more...)
|
60 |
All |
18 Years to 55 Years (Adult) |
NCT02824614 |
Poly Gut |
|
June 2016 |
October 2018 |
October 2018 |
July 6, 2016 |
January 3, 2018 |
|
- St Claraspital
Basel, Switzerland
|
|
| 9 |
NCT02335021 |
Recruiting |
The Effect of Artificial Sweeteners (AFS) on Sweetness Sensitivity, Preference and Brain Response in Adults |
- Impairment of Oral Perception
- Insulin Resistance
|
- Dietary Supplement: Sucralose
- Dietary Supplement: Sucrose
- Dietary Supplement: Sucralose + maltodextrin
- Dietary Supplement: Sucralose + Sucrose
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Basic Science
|
- Ratings of taste sensitivity
- Ad libitum food intake
- brain response to taste stimuli
|
120 |
All |
23 Years to 45 Years (Adult) |
NCT02335021 |
0405026766-2 |
AFS-adult |
January 2015 |
January 2019 |
February 2019 |
January 9, 2015 |
November 20, 2017 |
|
- The John B Pierce Laboratory
New Haven, Connecticut, United States
|
|
| 10 |
NCT02894931 |
Recruiting |
Effects of Dietary Interventions on Serum and Macrophage Atherogenicity |
- Dietary Habits
- Serum; Disease
- Macrophage Atherogenicity
- Atherosclerosis
|
- Dietary Supplement: monosaccharides
- Dietary Supplement: Disaccharides
- Dietary Supplement: Amino acids
- (and 2 more...)
|
Interventional
|
Not Applicable |
- Rambam Health Care Campus
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
|
- serum Oxidation dietary factors, i.e. monosaccharides, disaccharides, amino acids, or artificial atherogenicity of serum
- macrophages cellular Oxidation.
- Serum lipids- Cholesterol
- (and 3 more...)
|
90 |
Male |
18 Years to 50 Years (Adult) |
NCT02894931 |
0285-16-RMB CTIL |
|
September 2016 |
May 2018 |
August 2018 |
September 9, 2016 |
September 27, 2016 |
|
- Rambam Health care center
Haifa, Israel
|
|
| 11 |
NCT03543644 |
Recruiting
New |
Strategies To OPpose SUGARS With Non-nutritive Sweeteners Or Water (STOP SUGARS NOW) Trial |
- Healthy
- Overweight and Obesity
- Metabolic Syndrome
- (and 8 more...)
|
- Other: Sugar-sweetened beverage (SSB)
- Other: Non-nutritive sweetened beverages (NSB)
- Other: Water
|
Interventional
|
Not Applicable |
- University of Toronto
- Canadian Institutes of Health Research (CIHR)
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- Gut microbiome composition measured by 16S rRNA gene sequencing
- 75g OGTT derived plasma glucose iAUC
- Change in waist circumference
- (and 4 more...)
|
75 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT03543644 |
CIHR-STOP SUGARS NOW |
|
May 31, 2018 |
June 2020 |
November 2020 |
June 1, 2018 |
June 5, 2018 |
|
- St Michael's Hospital
Toronto, Ontario, Canada
|
|
| 12 |
NCT02591134 |
Recruiting |
EffectS of Non-nutritive sWeetened Beverages on appetITe During aCtive weigHt Loss |
|
- Other: Non Nutritive Sweetened Beverages
- Other: Control
|
Interventional
|
Not Applicable |
- Professor Jason Halford
- American Beverage Association
- University of Liverpool
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Basic Science
|
- Initial change in weight
- Changes in appetite/programme experience (all VAS)
- Circulating biomarkers of health
- (and 3 more...)
|
432 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02591134 |
ULKLABA01 |
SWITCH |
July 2016 |
December 2020 |
December 2020 |
October 29, 2015 |
September 15, 2017 |
|
- University of Liverpool
Liverpool, United Kingdom
|
|
| 13 |
NCT03032640 |
Recruiting |
Interactions of Human Gut Microbiota With Intestinal Sweet Taste Receptors |
|
- Other: Oral Glucose Tolerance Test (OGTT)
- Other: Assessment of dietary compliance
- Other: Stool sampling
- (and 3 more...)
|
Interventional
|
Not Applicable |
- Translational Research Institute for Metabolism and Diabetes, Florida
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Basic Science
|
- Blood analyzed by way of NOVA StatStrip Meter and Milliplex Map Kit.
- Short chain fatty acid analyses
|
90 |
All |
18 Years to 45 Years (Adult) |
NCT03032640 |
TRIMDFH 982524 |
ISTAR-micro |
January 2017 |
June 2018 |
December 2019 |
January 26, 2017 |
February 14, 2018 |
|
- Florida Hospital Translational Research Institute for Metabolism and Diabetes
Orlando, Florida, United States
|
|
| 14 |
NCT02544763 |
Recruiting |
A Randomized Controlled Trial of Cannabidiol (GWP42003-P, CBD) for Seizures in Tuberous Sclerosis Complex (GWPCARE6) |
- Tuberous Sclerosis Complex
- Seizures
|
- Drug: GWP42003-P
- Drug: Placebo
|
Interventional
|
Phase 3 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in seizure frequency
- Number of treatment responders
- Number of participants with worsening, no change, or improvements in seizure frequency
- (and 18 more...)
|
210 |
All |
1 Year to 65 Years (Child, Adult, Older Adult) |
NCT02544763 |
GWEP1521 Blinded Phase
2015-002154-12 |
|
April 2016 |
September 2018 |
September 2018 |
September 9, 2015 |
October 24, 2017 |
|
- Massachusetts General Hospital
Boston, Massachusetts, United States
|
|
| 15 |
NCT02607891 |
Recruiting |
A Study to Investigate Possible Drug-drug Interactions Between Stiripentol or Valproate and Cannabidiol in Patients With Epilepsy |
|
- Drug: GWP42003-P
- Drug: Placebo
|
Interventional
|
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Maximum plasma concentration (Cmax) of STP, VPA, cannabidiol (CBD).
- Time to the maximum plasma concentration (Tmax) of STP, VPA and CBD.
- Area under the curve (AUC) from zero to final time of positive detection (0-t) of STP, VPA and CBD.
- (and 15 more...)
|
40 |
All |
16 Years to 55 Years (Child, Adult) |
NCT02607891 |
GWEP1447 Blinded Phase
2015-002939-18 |
|
October 2016 |
August 2018 |
August 2018 |
November 18, 2015 |
November 1, 2017 |
|
- Elancourt, France
- Paris, France
- Rennes, France
- (and 7 more...)
|
|
| 16 |
NCT02953548 |
Recruiting |
Trial of Cannabidiol (CBD; GWP42003-P) for Infantile Spasms (GWPCARE7) |
|
|
Interventional
|
Phase 3 |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of participants who experienced a treatment-emergent adverse event.
- Number of participants with a potentially clinically significant change in clinical laboratory tests.
- Number of participants with a clinically significant change in 12-lead electrocardiogram (ECG).
- (and 4 more...)
|
10 |
All |
1 Month to 24 Months (Child) |
NCT02953548 |
GWEP15100 Pilot Phase
2015-004904-50 |
|
March 16, 2017 |
December 2017 |
December 2017 |
November 2, 2016 |
October 24, 2017 |
|
- Wake Forest Baptist Medical Center
Winston-Salem, North Carolina, United States - Nationwide Children's Hospital
Columbus, Ohio, United States - Le Bonheur Children's Hospital
Memphis, Tennessee, United States - (and 3 more...)
|
|
| 17 |
NCT03150992 |
Recruiting |
EDMONd - Elemental Diet in Bowel Obstruction |
- Ovarian Cancer
- Ovarian Neoplasms
- Ovarian Disease
- (and 6 more...)
|
- Dietary Supplement: Elemental 028 Extra Liquid
|
Interventional
|
Not Applicable |
- Royal Surrey County Hospital NHS Foundation Trust
- University of Surrey
- Target Ovarian Cancer
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Taste acceptability of ED
- Change in incidence of vomiting
- Change in incidence of pain
- (and 4 more...)
|
34 |
Female |
18 Years to 90 Years (Adult, Older Adult) |
NCT03150992 |
16/LO/2079
32895 |
EDMONd |
July 19, 2017 |
March 2019 |
December 2019 |
May 12, 2017 |
September 28, 2017 |
|
- Royal Surrey County Hospital NHS Foundation Trust
Guildford, Surrey, United Kingdom
|
|
| 18 |
NCT02548767 |
Recruiting |
Adverse Metabolic Effects of Dietary Sugar |
- Chronic Disease of Cardiovascular System
- Type 2 Diabetes
- Obesity
|
- Other: high fructose corn syrup
- Other: aspartame
- Other: Energy-balanced diet
- Other: Ad libitum diet
|
Interventional
|
Not Applicable |
- University of California, Davis
- Touro University, California
- University of Southern California
- (and 2 more...)
|
Other / U.S. Fed / NIH |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Basic Science
|
- Change of de novo lipogenesis: palmitate tracer-to-tracee ratios by gas chromatography-mass spectrometry.
- Change of endogenous glucose production measured by standard dilution techniques
- Change of whole body insulin sensitivity
- (and 3 more...)
|
72 |
All |
18 Years to 40 Years (Adult) |
NCT02548767 |
499106
1R01HL121324 |
|
February 2016 |
June 2019 |
June 2020 |
September 14, 2015 |
July 14, 2017 |
|
- University of California, Davis
Davis, California, United States - Clinical Research Center
Sacramento, California, United States - Touro University California Translational Research Clinic and Student Health Clinic
Vallejo, California, United States
|
|
| 19 |
NCT02988999 |
Recruiting |
Efficacy of D-allulose on Weight and Fat Loss and Insulin Resistance in Non-diabetic Obese Subjects |
|
- Dietary Supplement: D-allulose
- Dietary Supplement: erythritol
|
Interventional
|
Not Applicable |
- Chiang Mai University
- Kagawa University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Body composition change after 24 weeks of D-allulose consumption to erythritol consumption
- Body weight change after 24 weeks of D-allulose consumption to erythritol consumption
- BMI change after 24 weeks of D-allulose consumption to erythritol consumption
- (and 9 more...)
|
60 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT02988999 |
CMU-D-allulose02 |
|
September 2016 |
August 2017 |
November 2017 |
December 12, 2016 |
December 12, 2016 |
|
- Faculty of Medicine, Chiang Mai University
Muang Chiang Mai, Chiang Mai, Thailand
|
|
| 20 |
NCT03301311 |
Recruiting |
Personalized Research on Diet in Ulcerative Colitis and Crohn's Disease |
- Inflammatory Bowel Diseases
- Crohn Disease
- Ulcerative Colitis
|
- Other: Specific Carbohydrate Diet (SCD)
- Other: Modified Specific Carbohydrate Diet (MSCD)
|
Interventional
|
Not Applicable |
- Children's Hospital Medical Center, Cincinnati
- University of California, San Francisco
- Seattle Children's Hospital
- (and 2 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Stool frequency
- Stool Consistency
- Pain Interference
- (and 7 more...)
|
120 |
All |
7 Years to 17 Years (Child) |
NCT03301311 |
CIN001-PRODUCE |
PRODUCE |
April 10, 2018 |
December 2, 2019 |
December 2, 2019 |
October 4, 2017 |
May 18, 2018 |
|
- Lucile Packard Children's Hospital
Palo Alto, California, United States - University of California San Francisco Benioff Children's Hospita;
San Francisco, California, United States - Nemours, Alfred I duPont Hospital for Children
Wilmington, Delaware, United States - (and 8 more...)
|
|
| 21 |
NCT02448667 |
Recruiting |
Energy Supplements to Improve Exercise Tolerance in Metabolic Myopathies |
- Glycogen Storage Disease Type III
|
- Dietary Supplement: FAXE Kondi
- Dietary Supplement: Faxe Kondi Free
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- maximal work capacity
- Peak oxygen consumption
- Peak workload
- (and 4 more...)
|
15 |
All |
18 Years and older (Adult, Older Adult) |
NCT02448667 |
H-4-2014-014 |
|
January 2015 |
November 2017 |
February 2018 |
May 19, 2015 |
January 20, 2017 |
|
- Copenhagen Neuromuscular Center, department 3342, Rigshospitalet
Copenhagen, Region hovedstaden, Denmark
|
|
| 22 |
NCT03202108 |
Not yet recruiting |
Evaluation of Krio in Children and Adults With Epilepsy |
- Ketogenic Dieting
- Epilepsy
- Glucose Transporter Type 1 Deficiency Syndrome
|
|
Interventional
|
Not Applicable |
- Vitaflo International, Ltd
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Product compliance daily diary
- GI tolerance daily diary
- Ease of use questionnaire
|
15 |
All |
3 Years and older (Child, Adult, Older Adult) |
NCT03202108 |
MCT-KRIO-2015-01-06 |
Krio |
August 3, 2017 |
September 15, 2017 |
September 30, 2017 |
June 28, 2017 |
July 6, 2017 |
|
- National Hospital for Neurology and Neurosurgery
London, Greater London, United Kingdom - Leeds Children's Hospital
Leeds, West Yorkshire, United Kingdom
|
|
| 23 |
NCT02934321 |
Recruiting |
Assessment of Satiety Following Oral Administration of an Erythritol Sweetened Beverage |
- Satiety in Healthy Volunteers
|
- Dietary Supplement: Erythritol
- Dietary Supplement: Aspartame
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Ghrelin taken over 2 hours post beverage total area under curve (AUC)
- Ghrelin minimum concentration
- Serum insulin concentration
- Change in hunger rating scale
|
16 |
All |
18 Years to 40 Years (Adult) |
NCT02934321 |
IRB201601141 |
|
September 18, 2017 |
August 29, 2018 |
August 29, 2019 |
October 14, 2016 |
April 20, 2018 |
|
- University of Florida Clinical Research Center
Gainesville, Florida, United States
|
|
| 24 |
NCT02611102 |
Recruiting |
Effect of Butter & MCT Oil on Lipoproteins - A RCT |
|
- Dietary Supplement: MCT oil + Butter in Coffee
|
Interventional
|
Not Applicable |
- Walter Reed National Military Medical Center
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Changes in apolipoprotein B
- non-HDL-c
- LDL-c
- (and 5 more...)
|
60 |
All |
18 Years to 45 Years (Adult) |
NCT02611102 |
404482-2 |
|
March 2016 |
July 2018 |
July 2019 |
November 20, 2015 |
September 26, 2016 |
|
- Walter Reed National Military Medical Center
Bethesda, Maryland, United States
|
|
| 25 |
NCT03316742 |
Not yet recruiting |
Pilot Study on Weight Loss in Guinea Bissau |
- Overweight and Obesity
- Weight Loss
|
- Combination Product: Intervention 1
- Combination Product: Intervention 2
|
Interventional
|
Not Applicable |
- Tufts University
- USDA Human Nutrition Research Center on Aging
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in weight
- Intervention Adherence
- Change in Blood Pressure
- (and 5 more...)
|
50 |
All |
20 Years to 65 Years (Adult, Older Adult) |
NCT03316742 |
12377 |
|
June 2018 |
August 2018 |
August 2018 |
October 20, 2017 |
February 27, 2018 |
|
- International Partnership for Health Development
Bissau, Guinea-Bissau
|
|
| 26 |
NCT03423069 |
Recruiting |
Low FODMAPs Diet vs. Specific Dietary Advice in Patients With IBS Diarrheal Variant |
|
- Dietary Supplement: Diet low in FODMAPs
- Dietary Supplement: Specific dietary advice for IBS
|
Interventional
|
Not Applicable |
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Change in the total score of the irritable bowel syndrome - severity scoring system (IBS-SSS) questionnaire
- Change in the score of the single symptom items of the irritable bowel syndrome - severity scoring system (IBS-SSS) questionnaire
- Change in the intestinal permeabily evaluation
- (and 2 more...)
|
62 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03423069 |
RC2018B |
DIETSINIBS |
February 5, 2018 |
June 30, 2019 |
December 31, 2020 |
February 6, 2018 |
March 5, 2018 |
|
- IRCCS Saverio de Bellis
Castellana Grotte, Bari, Italy
|
|
| 27 |
NCT03525184 |
Recruiting |
Nutrition Intervention to Promote Immune Recovery From Sleep Restriction |
|
- Other: Additional protein and multi-nutrient beverage
- Other: Placebo beverage
|
Interventional
|
Not Applicable |
- United States Army Research Institute of Environmental Medicine
|
U.S. Fed |
- Allocation: Non-Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Participant)
- Primary Purpose: Basic Science
|
- Partial skin barrier restoration
- Cytokine response of local wound fluid (e.g., IL-6, IL-8, TNF-a)
|
20 |
All |
18 Years to 45 Years (Adult) |
NCT03525184 |
17-27HC |
|
February 12, 2018 |
October 2019 |
December 2019 |
May 15, 2018 |
May 18, 2018 |
|
- U.S. Army Research Institute of Environmental Medicine
Natick, Massachusetts, United States
|
|
| 28 |
NCT02818777 |
Recruiting |
A Study of Tolerability and Efficacy of Cannabidiol on Tremor in Parkinson's Disease |
|
- Drug: cannabidiol
- Drug: placebo
|
Interventional
|
Phase 2 |
- University of Colorado, Denver
- Colorado Department of Public Health and Environment
- GW Research Ltd
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Frequency of study-related adverse events at each dose level
- Changes in Vital Signs
- Changes in Physical Exam
- (and 21 more...)
|
60 |
All |
45 Years to 78 Years (Adult, Older Adult) |
NCT02818777 |
15-0929 |
|
July 2016 |
December 2018 |
June 2019 |
June 30, 2016 |
April 28, 2017 |
|
- University of Colorado School of Medicine
Aurora, Colorado, United States
|
|
| 29 |
NCT02224703 |
Recruiting |
GWPCARE2 A Study to Investigate the Efficacy and Safety of Cannabidiol (GWP42003-P) in Children and Young Adults With Dravet Syndrome |
|
- Drug: GWP42003-P
- Drug: Placebo Control
|
Interventional
|
Phase 3 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Percentage change from baseline in convulsive seizure frequency during the treatment period.
- Number of subjects considered treatment responders, defined as those with a ≥25%, ≥50% or ≥75% reduction in convulsive seizures from baseline.
- Number of subjects who are convulsive seizure free.
- (and 5 more...)
|
150 |
All |
2 Years to 18 Years (Child, Adult) |
NCT02224703 |
GWEP1424
2014-002939-34 |
|
March 2015 |
May 2017 |
June 2017 |
August 25, 2014 |
October 12, 2016 |
|
- Sutter Neuroscience Institute
Sacramento, California, United States - Miami Children's Hospital
Miami, Florida, United States - McFarland Clinic
Ames, Iowa, United States - (and 7 more...)
|
|
| 30 |
NCT03384719 |
Not yet recruiting |
The Effect of Milk Protein vs Blends of Milk and Plant Protein on Growth Markers in 7-8 Year Old Healthy Danish Children |
- Growth Acceleration
- Growth; Stunting, Nutritional
|
- Dietary Supplement: 35 g protein (30% milk + 70% rapeseed)
- Dietary Supplement: 35 g protein (54% milk + 46% rapeseed)
- Dietary Supplement: 35 g protein (100% milk)
|
Interventional
|
Not Applicable |
- University of Copenhagen
- Arla Foods
- University of Aarhus
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Basic Science
|
- Change in IGF-I between study arms
- Change in IGF-1 within study arms
- Change in IGF-1 between and within study arms
- (and 6 more...)
|
129 |
All |
7 Years to 8 Years (Child) |
NCT03384719 |
D221 |
PROGRO |
January 2018 |
April 2019 |
April 2019 |
December 27, 2017 |
December 28, 2017 |
|
|
|
| 31 |
NCT03218696 |
Not yet recruiting |
Comparison of a Protective Cough Syrup Against Placebo on Night Cough in Children 1-5 Years Coughing Since 1- 2 Days Due to Common Cold |
- Cough
- Acute Upper Respiratory Tract Infection
|
- Device: Cough Syrup for adults and children
- Device: Placebo
|
Interventional
|
Not Applicable |
- Clalit Health Services
- Aboca Spa Societa' Agricola
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Night cough frequency score reduction
- night cough intensity score reduction
- night cough bothersomeness score reduction
- (and 3 more...)
|
80 |
All |
1 Year to 5 Years (Child) |
NCT03218696 |
COM-17-0096 |
|
February 2018 |
September 2018 |
December 2018 |
July 14, 2017 |
January 29, 2018 |
|
- Pediatric Community Ambulatory Clinic - Petach-Tikva
Petaẖ Tiqwa, Israel - Pediatric Community Ambulatory Clinic
Petaẖ Tiqwa, Israel
|
|
| 32 |
NCT02616484 |
Recruiting |
Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency: |
- Pyruvate Dehydrogenase Complex Deficiency
|
- Drug: Dichloroacetate (DCA)
- Other: Placebo
- Genetic: Genotype
|
Interventional
|
Phase 3 |
- University of Florida
- Columbia University
- FDA Office of Orphan Products Development
- Medosome Biotec LLC
|
Other / U.S. Fed / Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- The efficacy will be measured between the groups by using the Observer Reported Outcome (ObsRO) measure of health.
- The number of participants with adverse events will be compared between the groups.
- Karnofsky/Lansky Performance Status
- (and 2 more...)
|
9 |
All |
6 Months to 17 Years (Child) |
NCT02616484 |
IRB201500698 - A
R01FD005407
FD-R-05407-01 |
DCA/PDCD |
October 1, 2017 |
June 30, 2020 |
June 30, 2020 |
November 30, 2015 |
June 11, 2018 |
|
- Children's Hospital of Orange County
Orange, California, United States - Stanford University
Stanford, California, United States - Children's National Medical Center
Washington, District of Columbia, United States - (and 6 more...)
|
|
| 33 |
NCT02520258 |
Recruiting |
Study of the Reversibility of Glucose Intolerance Caused by Chronic Aspartame Consumption |
- Glucose Metabolism Disorder
|
- Other: Oral glucose tolerance test (OGTT)
- Other: Diet soda containing aspartame only
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Sequential Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Interval changes in blood glucose
- Blood glucose
- Interval changes in Glucagon
- (and 15 more...)
|
75 |
All |
18 Years to 45 Years (Adult) |
NCT02520258 |
THU-0887 |
|
August 2015 |
June 2018 |
June 2019 |
August 11, 2015 |
March 23, 2018 |
|
- The Rockefeller University
New York, New York, United States
|
|
| 34 |
NCT02371694 |
Recruiting |
What is the Dose Response of Varying Meal Content of Fat on Postprandial Glycaemia in Children With T1DM? |
- Diabetes Mellitus, Type 1
|
|
Interventional
|
Not Applicable |
- Cork University Hospital
- National University of Ireland, Galway, Ireland
- John Hunter Children's Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Basic Science
|
- Glycaemic excursion
- Maximal glucose excursion
- Time to maximal glucose excursion
- (and 3 more...)
|
30 |
All |
8 Years to 18 Years (Child, Adult) |
NCT02371694 |
CorkUH |
REQINSOIL |
February 2015 |
December 2017 |
December 2018 |
February 26, 2015 |
April 13, 2017 |
|
- Cork University Hospital
Cork, Ireland
|
|
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