| 1 |
NCT03435562 |
Not yet recruiting |
Assessment of Two New Electronic Cigarettes in Cigarette Smokers |
|
- Other: JUUL electronic cigarette
- Other: IQOS electronic cigarette
- Other: Own Brand cigarette
|
Interventional |
Not Applicable |
- Virginia Commonwealth University
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Plasma nicotine
- Hughes-Hatsukami Questionnaire
- Tiffany-Drobes Questionnaire of Smoking Urges
- (and 3 more...)
|
75 |
All |
18 Years to 55 Years (Adult) |
NCT03435562 |
HM20012013 |
|
April 2018 |
February 2019 |
February 2019 |
February 16, 2018 |
March 6, 2018 |
|
|
| 2 |
NCT02635620 |
Recruiting |
Changes in Psychological and Somatic Parameters Associated With Changing From Smoking to E-cigarettes |
- Exposure to Electronic Cigarettes
|
|
Observational |
|
- Ludwig-Maximilians - University of Munich
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- lung function
- quality of life
- respiratory tract inflammation activity
|
80 |
All |
18 Years and older (Adult, Senior) |
NCT02635620 |
EQualLife |
EQualLife |
October 2015 |
December 2017 |
March 2018 |
December 21, 2015 |
November 1, 2017 |
|
- Klinik für Psychiatrie und Psychotherapie - LMU Munich
Munich, Bavaria, Germany
|
| 3 |
NCT03098004 |
Recruiting |
Effects of e-Cigarettes on Nicotine Withdrawal |
|
|
Interventional |
Not Applicable |
- University of Southern California
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Participant)
- Primary Purpose: Other
|
- Positive Affect Negative Affect Schedule
- The Minnesota Nicotine withdrawal Scale
- Wisconsin Smoking Withdrawal Scale
- Questionnaire of Smoking Urges
|
40 |
All |
21 Years and older (Adult, Senior) |
NCT03098004 |
HS-16-00630 |
|
January 1, 2017 |
August 31, 2017 |
January 1, 2018 |
March 31, 2017 |
April 19, 2017 |
|
- USC Health, Emotion and Addiction Laboratory
Los Angeles, California, United States
|
| 4 |
NCT03235505 |
Not yet recruiting |
Efficacy and Safety of E-cigarettes for Smoking Cessation in Middle-aged Heavy Smokers |
- Smoking Cessation
- Electronic Cigarette
|
- Drug: Nicotine
- Drug: Varenicline Tartrate
- Behavioral: Motivational Interview
|
Interventional |
Phase 4 |
- Tuula Toljamo
- Lapland Central Hospital Rovaniemi Finland
- University of Oulu
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Smoking cessation during the follow-up visit at week 24
- Smoking cessation at any other study visit
- Reduce smoking at any study visit
|
450 |
All |
30 Years to 70 Years (Adult, Senior) |
NCT03235505 |
WI218780 |
EFFECT |
September 1, 2017 |
December 31, 2019 |
December 31, 2020 |
August 1, 2017 |
August 1, 2017 |
|
|
| 5 |
NCT03491059 |
Recruiting
New |
Feasibility of PET/CT to Detect the Oral/Pulmonary Distribution of Nicotine Following E-cigarette Use |
|
- Drug: C-11 labeled nicotine
- Radiation: PET/CT imaging
|
Interventional |
Phase 4 |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Nicotine biodistribution
- Nicotine uptake
- Nicotine clearance
|
40 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT03491059 |
SP0232/2017H0463 |
|
February 16, 2018 |
February 16, 2019 |
February 16, 2021 |
April 9, 2018 |
April 9, 2018 |
|
- Martha Morehouse Medical Plaza
Columbus, Ohio, United States
|
| 6 |
NCT02783768 |
Recruiting |
Ventilation and Pulmonary Endothelium Toxicities of E-cigarettes: A Randomized Crossover Pilot Study |
- Pulmonary Disease, Chronic Obstructive
- E-cigarettes
|
- Device: E-cigarette
- Other: Sham
- Drug: Hyperpolarized 3-Helium
- Drug: Gadolinium
|
Interventional |
Phase 1 |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Other
|
- Change in pulmonary microvascular blood flow (PMBF), measured on gadolinium-enhanced MRI, between e-cigarette exposed and unexposed conditions
- Change in ventilation defect percentage (VDP), measured on hyperpolarized 3-helium enhanced MRI, between e-cigarette exposed and unexposed conditions
- Regional change in PMBF, measured on gadolinium-enhanced MRI, between e-cigarette exposed and unexposed conditions
- (and 4 more...)
|
10 |
All |
21 Years to 35 Years (Adult) |
NCT02783768 |
AAAQ8089 |
VaPE-Tox |
March 1, 2017 |
May 2018 |
May 2018 |
May 26, 2016 |
March 28, 2017 |
|
- Columbia University Medical Center
New York, New York, United States
|
| 7 |
NCT03284632 |
Recruiting |
e-Cigarette - DNA Adducts |
- Smoking
- Cigarette Smoking
- Electronic Cigarettes
|
|
Observational |
|
- University of Minnesota - Clinical and Translational Science Institute
- National Institutes of Health (NIH)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- DNA Adducts
- Urinary 8-iso-PGF-2α
- Urinary PGEM
- (and 2 more...)
|
402 |
All |
18 Years and older (Adult, Senior) |
NCT03284632 |
2017NTLS040 |
|
July 11, 2017 |
August 1, 2021 |
August 1, 2022 |
September 15, 2017 |
September 15, 2017 |
|
- University of Minnesota
Minneapolis, Minnesota, United States
|
| 8 |
NCT03194256 |
Not yet recruiting |
Evaluating New Nicotine Standards for Cigarettes - Project 3 |
- Smoking, Cigarette
- Electronic Cigarettes
|
- Behavioral: Spectrum Research Cigarettes
|
Interventional |
Not Applicable |
- Brown University
- University of Pittsburgh
- University of Minnesota - Clinical and Translational Science Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Other
|
- Change in the number of cigarette puffs taken
|
120 |
All |
15 Years to 19 Years (Child, Adult) |
NCT03194256 |
1705001771 |
CENIC2-P3 |
September 1, 2017 |
February 28, 2022 |
February 28, 2022 |
June 21, 2017 |
June 21, 2017 |
|
- Brown University School of Public Health
Providence, Rhode Island, United States
|
| 9 |
NCT03379025 |
Not yet recruiting |
Effects of Electronic Cigarettes in Cigarette Smokers With Mild to Moderate COPD |
|
- Other: Electronic cigarette
|
Interventional |
Not Applicable |
- Massachusetts General Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Other
|
- Change in cigarettes per day
- Change in urine anabasine
- Change in urine cotinine
- (and 4 more...)
|
65 |
All |
40 Years to 80 Years (Adult, Senior) |
NCT03379025 |
2017P002418 |
|
February 2019 |
February 2021 |
August 2021 |
December 20, 2017 |
December 20, 2017 |
|
|
| 10 |
NCT03041493 |
Recruiting |
Investigation of the Effects of Electronic Cigarettes on Vascular Health |
|
- Behavioral: Electronic cigarette
- Behavioral: traditional cigarette
- Behavioral: (sham cigarette) - no actual exposure to cigarettes
|
Interventional |
Not Applicable |
- Memorial Sloan Kettering Cancer Center
- Weill Medical College of Cornell University
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Differences in levels of F2-isoprostanes in participants
|
60 |
All |
18 Years to 50 Years (Adult) |
NCT03041493 |
17-071 |
|
February 1, 2017 |
February 2019 |
February 2019 |
February 2, 2017 |
December 26, 2017 |
|
- Memorial Sloan Kettering Cancer Center
New York, New York, United States
|
| 11 |
NCT01979796 |
Not yet recruiting |
Antismoking Effects of Electronic Cigarettes in Subjects With Schizophrenia and Their Potential Influence on Cognitive Functioning. |
- Tobacco Smoking in Schizophrenic Patients
|
- Device: Ecig 24 mg nicotine
- Device: Ecig 0 mg nicotine
- Device: Nicotine free inhalator
|
Interventional |
Not Applicable |
- Universita degli Studi di Catania
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- smoking cessation
- Smoking reduction
|
153 |
All |
18 Years to 65 Years (Adult) |
NCT01979796 |
SCARIS |
SCARIS |
December 2017 |
September 2018 |
December 2018 |
November 8, 2013 |
May 9, 2017 |
|
|
| 12 |
NCT03480373 |
Recruiting
New |
Electronic Cigarette Use During Pregnancy |
- Cigarette Smoking-Related Carcinoma
|
|
Observational |
|
- UConn Health
- University of Colorado, Denver
- Hartford Hospital
- Roswell Park Cancer Institute
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- To compare the overall toxicant exposure in pregnant women who use electronic cigarettes compared to women who smoke conventional cigarettes.
|
375 |
Female |
16 Years to 45 Years (Child, Adult) |
NCT03480373 |
17-180-6 |
|
May 1, 2018 |
March 31, 2023 |
May 31, 2023 |
March 29, 2018 |
April 17, 2018 |
|
- University of Colorado
Denver, Colorado, United States - UCONN Health
Farmington, Connecticut, United States - Women's Ambulatory Health Services at Hartford Hospital
Hartford, Connecticut, United States
|
| 13 |
NCT03358953 |
Recruiting |
The Cardiovascular Impacts of Electronic Cigarettes in Comparison to the Use of Nicotine Replacement Patches |
|
- Device: Electron Cigarette
- Device: Nicotine Replacement Patch
|
Interventional |
Not Applicable |
- NHS Greater Glasgow and Clyde
|
Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Change in endothelial function as assessed by flow mediated dilation
- Changes in respiratory function assessed through pulmonary function tests
- Changes in endothelial function assessed by Endo-PAT2000, a non-invasive technique
- (and 3 more...)
|
100 |
All |
18 Years to 65 Years (Adult) |
NCT03358953 |
GN16CH051 |
VAPOUR |
December 17, 2016 |
February 2018 |
June 2018 |
December 2, 2017 |
December 2, 2017 |
|
- Glasgow Clinical Research Facility
Glasgow, Scotland, United Kingdom
|
| 14 |
NCT03084315 |
Recruiting |
Changes in Biomarkers Associated With Use of Electronic Cigarettes |
|
- Device: E-Cig Zero Nicotine
- Device: E-Cig 24mg Nicotine
|
Interventional |
Not Applicable |
- University of Minnesota - Clinical and Translational Science Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Basic Science
|
|
300 |
All |
18 Years and older (Adult, Senior) |
NCT03084315 |
1509M78241 |
|
November 15, 2016 |
March 1, 2019 |
March 1, 2020 |
March 20, 2017 |
March 20, 2017 |
|
- DCRU
Minneapolis, Minnesota, United States
|
| 15 |
NCT03036644 |
Recruiting |
Comparison of Electronic Cigarettes and Tobacco Cigarettes on Cardiovascular Function and Oxidative Stress |
- Cardiovascular Risk Factor
|
- Device: e-cigarette (PG+VG without nicotine; low temperature)
- Device: e-cigarette (PG+VG with nicotine; low temperature)
- Device: e-cigarette (PG+VG without nicotine; high temperature)
- (and 2 more...)
|
Interventional |
Not Applicable |
- Université Libre de Bruxelles
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Investigator)
- Primary Purpose: Basic Science
|
- Change in subcutaneous flux
- Change in Plasma and urine oxidative stress markers
- Change in aortic stiffness
- (and 2 more...)
|
60 |
All |
18 Years to 60 Years (Adult) |
NCT03036644 |
P2017/028 / B406201630672 |
|
January 15, 2017 |
June 30, 2018 |
October 30, 2018 |
January 30, 2017 |
February 8, 2017 |
|
- Erasme Hospital
Brussels, Brabant, Belgium
|
| 16 |
NCT02585791 |
Recruiting |
Evaluation of Acute and Subacute Effects of Nicotine Free Electronic Cigarette(NCFE) Vapors |
- Healthy Lifetime Non-smokers
|
- Other: Propylene Glycol
- Other: vegetable glycerin
- Other: PG+VG
|
Interventional |
Not Applicable |
- University of Miami
- James and Esther King Biomedical Research Program
|
Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: Single (Participant)
- Primary Purpose: Other
|
- changes on nasal potential difference (NPD) measurements
- changes on nasal nitric oxide
- changes on TGF-ß levels in nasal lavage
|
30 |
All |
18 Years and older (Adult, Senior) |
NCT02585791 |
20150373 |
|
February 22, 2017 |
February 2019 |
October 2019 |
October 23, 2015 |
September 11, 2017 |
|
- University of Miami School of Medicine
Miami, Florida, United States
|
| 17 |
NCT02188511 |
Recruiting |
Effects of Electronic Cigarettes on Lung Biology |
- Lung Disease
- Lung Disorder
|
- Other: Group A
- Other: Group B
- Other: Group C
- (and 2 more...)
|
Interventional |
Not Applicable |
- Weill Medical College of Cornell University
|
Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Basic Science
|
- Airway epithelium and aveolar macrophage
|
50 |
All |
21 Years to 85 Years (Adult, Senior) |
NCT02188511 |
1312014623 |
|
January 2014 |
December 2019 |
December 2019 |
July 11, 2014 |
May 25, 2017 |
|
- Weill Cornell Medical College
New York, New York, United States
|
| 18 |
NCT02897401 |
Not yet recruiting |
Determination of Carcinogens Nicotine in Electronic Cigarettes Users |
- Smoking
- Carcinogenesis of the Nicotine
|
- Biological: pregnancy test
- Biological: urinary cotinine assesment
- Biological: Urinary NNN assesement
- (and 2 more...)
|
Interventional |
Not Applicable |
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- NNN urinary concentrations obtained in the group "electronic cigarette" versus group "nocotine replacement treatment".
- NNN urinary concentrations obtained in the group "electronic cigarette" versus group "smocker"
- NNN urinary concentrations obtained in the group "electronic cigarette" versus group "no consumption of nicotine"
- (and 2 more...)
|
80 |
All |
18 Years and older (Adult, Senior) |
NCT02897401 |
P150932 |
CANICE |
September 2016 |
November 2017 |
November 2017 |
September 13, 2016 |
September 13, 2016 |
|
- APHP, Paul Brousse Hospital
Villejuif, France
|
| 19 |
NCT03473483 |
Not yet recruiting |
Cigarette Harm Reduction With Scheduled Electronic Cigarette Use |
- Nicotine Dependence
- Tobacco Toxicity
- Nicotine Dependence, Cigarettes
- (and 2 more...)
|
|
Interventional |
Not Applicable |
- University of California, San Francisco
- National Institutes of Health (NIH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Nicotine delivery
- Systemic nicotine exposure
- Subjective effects of Nicotine
- (and 8 more...)
|
20 |
All |
21 Years and older (Adult, Senior) |
NCT03473483 |
17-23142 |
NIDA-SREC |
June 1, 2018 |
June 1, 2020 |
June 1, 2020 |
March 22, 2018 |
March 22, 2018 |
|
- UCSF Tobacco Research Center
San Francisco, California, United States - Zuckerberg San Francisco General Hospital - CTSI
San Francisco, California, United States
|
| 20 |
NCT03089541 |
Recruiting |
Electronic Cigarette Use in Young Adult Men and Women |
- Cigarette Smoking
- Tobacco Use
|
|
Interventional |
Not Applicable |
- Yale University
- APT Foundation, Inc.
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Withdrawal scores
- Satisfaction with electronic cigarettes
- Frequency of electronic cigarette use
|
30 |
All |
18 Years to 29 Years (Adult) |
NCT03089541 |
1612018726 |
|
May 24, 2017 |
December 1, 2018 |
January 1, 2019 |
March 24, 2017 |
February 21, 2018 |
|
- Yale University
New Haven, Connecticut, United States
|
| 21 |
NCT01782599 |
Recruiting |
Electronic Cigarettes and Reactivity to Smoking Cues |
|
- Other: Dual nicotine patch and electronic cigarette
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Reduction in Cue Reactivity
|
125 |
All |
18 Years to 45 Years (Adult) |
NCT01782599 |
E-cigarettes and Cues |
|
January 2013 |
January 2020 |
January 2020 |
February 4, 2013 |
April 19, 2018 |
|
- Mclean Hospital Imaging Center
Belmont, Massachusetts, United States
|
| 22 |
NCT02596685 |
Recruiting |
Effects of Electronic Cigarette Use on the Lungs |
- Current Smoker
- Never Smoker
- Tobacco Use Disorder
|
- Procedure: Bronchoscopy
- Other: Electronic Cigarette
- Other: Laboratory Biomarker Analysis
- Other: Questionnaire Administration
|
Interventional |
Not Applicable |
- Ohio State University Comprehensive Cancer Center
- National Cancer Institute (NCI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Biomarker expression analysis to include cell counts
- Biomarker expression analysis to include inflammatory cytokines (Part I)
- Biomarker expression analysis to include untargeted metabolomics (Part I)
- (and 2 more...)
|
60 |
All |
21 Years to 30 Years (Adult) |
NCT02596685 |
OSU-15098
NCI-2015-00842
P50CA180908 |
|
December 2015 |
October 2018 |
December 2020 |
November 4, 2015 |
April 4, 2017 |
|
- Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States
|
| 23 |
NCT03209661 |
Recruiting |
Vascular Effects of a Single Bout of Electronic Cigarette Use |
|
- Drug: E-cigarette
- Drug: Nicotine 0%
- Drug: Menthol Inhalant Product
|
Interventional |
Phase 1 |
- University of Texas at Austin
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Participant)
- Primary Purpose: Other
|
- Changes in arterial stiffness and endothelial function with e-cigarette use.
|
35 |
All |
20 Years to 30 Years (Adult) |
NCT03209661 |
2016-04-0115 |
|
April 28, 2017 |
December 2017 |
December 2017 |
July 6, 2017 |
July 6, 2017 |
|
- Cardiovascular Aging Research Lab at UT Austin
Austin, Texas, United States
|
| 24 |
NCT02553577 |
Recruiting |
Impact of Electronic Cigarettes on Perinatal Immune Responsiveness and Birth Outcomes |
- Immune Response
- Birth Weight
- Gestational Age
|
|
Observational |
|
- Kristin Ashford
- Virginia Commonwealth University
- University of Kentucky
|
Other |
- Observational Model: Other
- Time Perspective: Prospective
|
- Gestational age at birth
- Infant birth weight
- Change in Prenatal Cytokine level in each trimester and postpartum
|
360 |
Female |
18 Years to 44 Years (Adult) |
NCT02553577 |
1R01DA040694-01 |
|
September 2015 |
August 2019 |
August 2019 |
September 17, 2015 |
June 23, 2017 |
|
- University of Kentucky Prenatal Clinics, Good Samaritian and Polk Dalton
Lexington, Kentucky, United States
|
| 25 |
NCT02878421 |
Recruiting |
Vascular EffectS of regUlar Cigarettes Versus electronIc Cigarette USe |
|
- Device: electronic cigarette + 16mg nicotine & flavor
- Other: electronic cigarette + 0mg nicotine & flavor
- Other: Tobacco cigarette
|
Interventional |
Not Applicable |
- University of Dundee
- NHS Tayside
- British Heart Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Other
|
- Change in FMD between the TC group and the EC-nicotine free groups
- Change in FMD between EC-nicotine and EC-nicotine free groups
- Change in Pulse Wave Velocity between the TC group and the EC-nicotine free groups.
- Change in Augmentation Index@75bpm between the TC group and the EC-nicotine free groups
|
135 |
All |
18 Years and older (Adult, Senior) |
NCT02878421 |
2014CV10 |
VESUVIUS |
September 2016 |
June 30, 2018 |
June 30, 2018 |
August 25, 2016 |
March 26, 2018 |
|
- University of Dundee
Dundee, Tayside, United Kingdom
|
| 26 |
NCT02892396 |
Not yet recruiting |
Influence of Electronic Cigarettes in the Evaluation of the Inflammatory Response in Patients With a Diagnosis of COPD |
- Chronic Obstructive Pulmonary Disease
|
|
Observational |
|
- Fundacio Catalana de Pneumologia
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Evaluation of inflammatory response
- Clinical symptoms associated with COPD
- Tobacco withdrawal
|
20 |
Male |
18 Years to 80 Years (Adult, Senior) |
NCT02892396 |
STUDY ECIGPOC |
|
September 2016 |
August 2018 |
March 2019 |
September 8, 2016 |
September 9, 2016 |
|
|
| 27 |
NCT03449017 |
Recruiting |
Reactions to E-cigs and Alcohol |
- Alcohol Abuse
- Nicotine Dependence Tobacco Product
|
|
Interventional |
Not Applicable |
- Indiana University
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
|
Other / NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Alcohol related attentional bias-Reaction time
- Alcohol related attentional bias-Initial orientation
- Alcohol related attentional bias-Delayed disengagement
- (and 7 more...)
|
40 |
All |
21 Years and older (Adult, Senior) |
NCT03449017 |
1511771735
F31AA024682 |
|
March 24, 2017 |
May 30, 2018 |
May 30, 2018 |
February 28, 2018 |
February 28, 2018 |
|
- Indiana Univerisity Purdue University Indianapolis
Indianapolis, Indiana, United States
|
| 28 |
NCT02752022 |
Recruiting |
Monitoring the Transition From Smoking to E-cigarettes |
|
|
Observational |
|
- St George's, University of London
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Change of levels of DNA adducts analysed by high resolution liquid chromatography
- Change of levels of tobacco specific nitrosamines analysed by high resolution liquid chromatography
- Change of levels of stress hormones analysed by ELISA
- (and 10 more...)
|
50 |
All |
18 Years to 65 Years (Adult) |
NCT02752022 |
16.0070 |
|
September 2016 |
March 2018 |
April 2018 |
April 26, 2016 |
October 24, 2017 |
|
- St George's Hospital
London, United Kingdom
|
| 29 |
NCT03010995 |
Not yet recruiting |
The Acute Cardiovascular Effects of Nicotine in E-cigarettes (ACE) Study |
- Cigarette Smoking Toxicity
- Nicotine
- Acute Cardiovascular Disease
|
|
Interventional |
Phase 1 |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Other
|
- Endothelial function
- Heart rate
- Blood pressure
- (and 2 more...)
|
40 |
All |
18 Years to 40 Years (Adult) |
NCT03010995 |
16.1079 |
ACE |
May 15, 2018 |
August 15, 2019 |
October 15, 2020 |
January 5, 2017 |
November 1, 2017 |
|
- University of Louisville
Louisville, Kentucky, United States
|
| 30 |
NCT02918630 |
Not yet recruiting |
E-cigarettes to Promote Smoking Reduction Among Individuals With Schizophrenia |
|
- Drug: Nicotine Patch
- Drug: E-cigarette
|
Interventional |
Not Applicable |
- The University of Texas Health Science Center, Houston
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Change in smoking as assessed by breath Carbon Monoxide
- Change in Smoking as assessed by urinary cotinine
- Change in smoking as assessed by a smoking diary
- (and 17 more...)
|
20 |
All |
18 Years to 65 Years (Adult) |
NCT02918630 |
HSC-MS-16-0667 |
|
October 2016 |
October 2017 |
|
September 29, 2016 |
September 29, 2016 |
|
- University of Texas Health Science Center at Houston
Houston, Texas, United States
|
| 31 |
NCT02417467 |
Recruiting |
Evaluating the Efficacy of E-Cigarette Use for Smoking Cessation (E3) Trial |
|
- Other: Nicotine E-Cigarette
- Other: Non-Nicotine E-Cigarette
- Behavioral: Counseling
|
Interventional |
Phase 3 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Number of participants with 7-day point prevalence smoking abstinence
- Number of participants with continuous abstinence from smoking
- Change in daily cigarette consumption
- (and 3 more...)
|
486 |
All |
18 Years and older (Adult, Senior) |
NCT02417467 |
E3
MOP-133727 |
|
November 2016 |
January 2019 |
June 2020 |
April 15, 2015 |
March 22, 2018 |
|
- Jewish General Hospital
Montreal, Quebec, Canada
|
| 32 |
NCT02955329 |
Not yet recruiting |
E-cigarette THC Study |
|
- Drug: Tetrahydrocannabinol
|
Interventional |
Not Applicable |
- University of California, San Francisco
- National Institutes of Health (NIH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Participant)
|
- Amount of THC inhaled and systematically retained
- Max plasma THC concentration (Cmax)
- Time to max plasma concentration (Tmax)
- (and 5 more...)
|
14 |
All |
21 Years to 70 Years (Adult, Senior) |
NCT02955329 |
16-20835 |
|
January 2017 |
July 2017 |
January 2018 |
November 4, 2016 |
November 8, 2016 |
|
- Zuckerberg San Francisco General Hospital - CTSI
San Francisco, California, United States
|
| 33 |
NCT02724241 |
Recruiting |
E-Cigarettes and SNA |
|
- Other: one time exposure to e-cig with nicotine
- Other: One time exposure to e-cigarette without nicotine
- Other: one time exposure to empty e-cigarette
|
Interventional |
Not Applicable |
- University of California, Los Angeles
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Heart Rate variability
- Paraoxonase
- muscle sympathetic nerve activity
|
120 |
All |
21 Years to 45 Years (Adult) |
NCT02724241 |
14-000731 |
|
April 2015 |
December 2018 |
December 2019 |
March 31, 2016 |
March 31, 2016 |
|
- UCaliforniaLA
Los Angeles, California, United States
|
| 34 |
NCT03023397 |
Recruiting |
Evaluation of the Effect of a Nasal Allergen Challenge With Dermatophagoides Farinae Extract on Nasal Airway Inflammation in Allergic Individuals, Comparing E-cigarette Users to Cigarette Smokers and Non-smokers. |
- Healthy Participants
- Tobacco Smokers
|
|
Interventional |
Phase 1 |
- University of North Carolina, Chapel Hill
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Change in eosinophils/mL in nasal lavage fluid (NLF)
- Nasal lavage fluid cytokines
- Nasal epithelial cell messenger ribonucleic acid (mRNA)
|
45 |
All |
18 Years to 50 Years (Adult) |
NCT03023397 |
16-1622
P50HL120100-04 |
Mitey Nose |
March 27, 2017 |
August 2018 |
October 2018 |
January 18, 2017 |
March 16, 2018 |
|
- UNC Center for Environmental Medicine, Asthma and Lung Biology
Chapel Hill, North Carolina, United States
|
| 35 |
NCT02740595 |
Recruiting |
E-cigarettes and Blood Vessel Function |
|
- Other: one time exposure to e-cig with nicotine
- Other: one time exposure to e-cig without nicotine
- Other: one time exposure to empty e-cig
|
Interventional |
Not Applicable |
- University of California, Los Angeles
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Flow mediated dilatation (FMD)
- Paraoxonse
|
120 |
All |
21 Years to 45 Years (Adult) |
NCT02740595 |
14-000743 |
|
August 2015 |
December 2018 |
December 2019 |
April 15, 2016 |
April 15, 2016 |
|
- UCaliforniaLA
Los Angeles, California, United States
|
| 36 |
NCT03028558 |
Recruiting |
Biology of the Oral Epithelium of E-Cigarette Smokers |
|
|
Observational |
|
- Weill Medical College of Cornell University
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- The biology of participants oral epithelial cells
- The biology of the genes of the oral epithelium
|
125 |
All |
21 Years to 35 Years (Adult) |
NCT03028558 |
1512016796 |
|
January 2017 |
January 2018 |
January 2018 |
January 23, 2017 |
May 25, 2017 |
|
- Department of Genetic Medicine, Weill Cornell Medical College
New York, New York, United States
|
| 37 |
NCT03249428 |
Not yet recruiting |
E-Cigarette Inner City RCT |
- Tobacco Dependence
- COPD Asthma
- Mental Illness
- Substance Use
|
- Device: Improved Quality of Life of low-income Canadians that smoke tobacco and other substances
|
Interventional |
Not Applicable |
- Ottawa Hospital Research Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Quality of Life
- Smoking Prevalence
|
200 |
All |
16 Years and older (Child, Adult, Senior) |
NCT03249428 |
E-Cigarette Inner City RCT 001 |
|
September 3, 2018 |
September 2021 |
September 2021 |
August 15, 2017 |
April 17, 2018 |
|
- The Bridge Engagement Centre
Ottawa, Ontario, Canada
|
| 38 |
NCT03072628 |
Recruiting |
E-cigarettes, Nicotine Inhaler, and Blood Vessel Function |
|
- Other: e-cig with nicotine
- Other: e-cig without nicotine
- Other: nicotine inhaler
- Other: sham control
|
Interventional |
Not Applicable |
- University of California, Los Angeles
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Flow Mediated dilatation (FMD)
- Heart rate variability (HRV)
- Paraoxonase (PON)
|
120 |
All |
21 Years to 45 Years (Adult) |
NCT03072628 |
14-000743-AM-00008 |
|
January 11, 2017 |
December 2020 |
December 2021 |
March 7, 2017 |
March 7, 2017 |
|
- UCaliforniaLA
Los Angeles, California, United States - UCaliforniaLA
Los Angeles, California, United States
|
| 39 |
NCT03061253 |
Recruiting |
E-cigarettes and Cardiovascular Function |
- Smoking Cessation
- Cardiovascular Diseases
- Microcirculation
- Macrocirculation
|
- Other: Electronic Cigarette and behavioural change support.
- Other: Nicotine-Free Electronic Cigarette and behavioural change support.
- Other: Nicotine Replacement Therapy and behavioural change support.
|
Interventional |
Not Applicable |
- Sheffield Hallam University
- King's College London
- Heart Research U.K.
- Help2Change
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Diagnostic
|
- Intervention effect on Flow-mediated dilatation (FMD) assessed via ultrasound (%FMD).
- Intervention effect on Flow-mediated dilatation assessed via ultrasound (%FMD).
- Intervention effect on Laser Doppler Flowmetry (Perfusion Units).
- (and 5 more...)
|
258 |
All |
18 Years and older (Adult, Senior) |
NCT03061253 |
HWB-2016-17-S&E-10 |
ISME-NRT |
April 24, 2017 |
November 21, 2019 |
April 23, 2020 |
February 23, 2017 |
April 20, 2018 |
|
- Sheffield Hallam University
Sheffield, Yorkshire, United Kingdom
|
| 40 |
NCT02848586 |
Recruiting |
Effects of E-cigarettes (ECIGs) on Pulmonary Inflammation and Behavior in HIV Infected Smokers |
- Lung Inflammation
- HIV Seropositivity
|
- Other: ECIGS
- Behavioral: mobile contingency management (mCM)
- Other: Usual brand
|
Interventional |
Not Applicable |
- Duke University
- National Institute of Allergy and Infectious Diseases (NIAID)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Changes in sputum glutathione concentration
- Change in sputum 8-isoprostane
- Change in nitrate/nitrite
- (and 4 more...)
|
20 |
All |
18 Years to 64 Years (Adult) |
NCT02848586 |
Pro00066481
P30AI064518 |
|
August 2016 |
November 2018 |
November 2019 |
July 28, 2016 |
January 31, 2018 |
|
- Duke University Medical Center
Durham, North Carolina, United States
|
| 41 |
NCT03075202 |
Recruiting |
Role of an E-cigarette on Smoking Displacement in Smokers With Schizophrenia |
- Schizophrenia and Related Disorders
|
- Device: e-cigarette, brand name JUUL
|
Observational |
|
- Weill Medical College of Cornell University
- Hunter College of The City University of New York
- University of Catania
- University of Stirling
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Smoking Displacement
- Partial Displacement
|
20 |
All |
21 Years to 65 Years (Adult) |
NCT03075202 |
1607017418 |
|
March 3, 2017 |
November 1, 2018 |
December 1, 2018 |
March 9, 2017 |
February 6, 2018 |
|
- Clinical and Translational Science Center, Weill Cornell Medicine, 525 E 68th Street, F-260
New York, New York, United States
|
| 42 |
NCT03453385 |
Not yet recruiting |
Clinical Outcomes of a Nationwide, Naturalistic E-Cig Trial (CONNECT) |
|
- Behavioral: Electronic Cigarette
|
Interventional |
Not Applicable |
- Medical University of South Carolina
- National Cancer Institute (NCI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Uptake
- Conversation
- Smoking Cessation
|
660 |
All |
21 Years and older (Adult, Senior) |
NCT03453385 |
493
1R01CA210625-01A1 |
CONNECT |
May 1, 2018 |
January 1, 2022 |
July 1, 2022 |
March 5, 2018 |
March 5, 2018 |
|
|
| 43 |
NCT02590393 |
Not yet recruiting |
The Role of Nicotine and Non-Nicotine Alkaloids in E-Cigarette Use and Dependence |
|
- Combination Product: E-cigarettes
|
Interventional |
Phase 3 |
- Duke University
- National Institute on Drug Abuse (NIDA)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Basic Science
|
- Expired air carbon monoxide (CO) to assess recent smoking
- Mean volume of e-cigarette solution used per day to assess e-cigarette use.
- Cigarette use, assessed by self-report in daily dairies
- E-cigarette use, assessed by self-report in daily dairies
|
375 |
All |
18 Years to 65 Years (Adult) |
NCT02590393 |
Pro00059780
1R01DA038554-01 |
Ecig1 |
June 1, 2018 |
June 1, 2020 |
December 1, 2020 |
October 29, 2015 |
February 21, 2018 |
|
- Duke Center for Smoking Cessation
Durham, North Carolina, United States
|
| 44 |
NCT02825459 |
Recruiting |
Does Abstinence From E-cigarettes Produce Withdrawal Symptoms? |
- Substance Withdrawal Syndrome
|
- Behavioral: Abstinence from e-cigarettes
|
Interventional |
Not Applicable |
- University of Vermont
- National Cancer Institute (NCI)
|
Other / NIH |
- Allocation: Non-Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Total score on the Minnesota Nicotine Withdrawal Scale (MNWS)
- Individual items on the Minnesota Nicotine Withdrawal Scale (MNWS)
- Questionnaire of E-cigarette Urges (brief)
- (and 3 more...)
|
120 |
All |
18 Years and older (Adult, Senior) |
NCT02825459 |
1R01CA192940-01
R01CA192940-01 |
|
July 2016 |
August 2018 |
August 2018 |
July 7, 2016 |
February 5, 2018 |
|
- Battelle Memorial Institute
Baltimore, Maryland, United States - University of Vermont
Burlington, Vermont, United States
|
| 45 |
NCT03492463 |
Not yet recruiting
New |
The Role of Nicotine Dose and Route of Delivery in Affecting Adoption of E-cigarettes and Reducing Exposure to Toxic Combustion Products |
- Nicotine Dependence, Cigarettes
|
- Drug: Nicotine patch
- Other: Placebo patch
- Other: E-cigarettes
- Other: Non-nicotine e-cigarettes
|
Interventional |
Phase 2 |
- Duke University
- National Institute on Drug Abuse (NIDA)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Basic Science
|
- Expired air carbon monoxide (CO) to assess recent smoking
- Cigarette use, assessed by self-report in daily dairies
- E-cigarette use, assessed by self-report in daily dairies
- Total urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL)
|
1600 |
All |
18 Years to 65 Years (Adult) |
NCT03492463 |
Pro00084132
P50DA027840-07 |
ENDS-Switch |
May 1, 2018 |
May 1, 2021 |
May 1, 2021 |
April 10, 2018 |
April 10, 2018 |
|
- Duke Center for Smoking Cessation
Durham, North Carolina, United States
|
| 46 |
NCT02964182 |
Recruiting |
Concomitant Use of Very Low Nicotine Content Cigarettes and e-Cigarettes |
- Mental and Behavioral Disorders Due to Use of Tobacco
|
- Procedure: Carbon Monoxide (CO) Testing
- Behavioral: Questionnaires
- Behavioral: Smartphone Assessments
- (and 4 more...)
|
Interventional |
Not Applicable |
- M.D. Anderson Cancer Center
- National Institute on Drug Abuse (NIDA)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Basic Science
|
- Effects of Dual Use of VLNCCC and ECIG on Nicotine Abuse Liability Among Daily Smokers (DS)
- Effects of Dual Use of VLNCCC and ECIG on Nicotine Abuse Liability Among Intermittent Smokers (ITS)
|
480 |
All |
18 Years to 65 Years (Adult) |
NCT02964182 |
2015-0638
R01DA042526 |
|
October 26, 2017 |
October 2020 |
October 2020 |
November 16, 2016 |
October 27, 2017 |
|
- University of Texas MD Anderson Cancer Center
Houston, Texas, United States
|
| 47 |
NCT03168191 |
Recruiting |
Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 2 |
|
- Drug: Nicotine
- Other: Experimental Flavor
- Other: Menthol Flavor
|
Interventional |
Phase 1 |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Other
|
- Change score in Liking/wanting of the e-cigarette
- Change score in rating of coolness
- Change score in rating of harshness/irritation
- (and 7 more...)
|
50 |
All |
18 Years to 20 Years (Adult) |
NCT03168191 |
1307012312-2 |
|
May 2, 2017 |
August 2018 |
August 2018 |
May 30, 2017 |
February 13, 2018 |
|
- CMHC, Substance Abuse Center
New Haven, Connecticut, United States
|
| 48 |
NCT03164668 |
Recruiting |
Menthol Flavored E-cigarette Use During a Simulated Ban of Menthol Cigarettes |
|
- Other: menthol flavored e-cigarette
- Other: tobacco flavored e-cigarette
|
Interventional |
Not Applicable |
- University of Minnesota - Clinical and Translational Science Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- number of cigarettes smoked
- number of e-cigarettes used
|
40 |
All |
18 Years to 64 Years (Adult) |
NCT03164668 |
RC-2016-0004 |
|
May 3, 2017 |
June 2018 |
June 2018 |
May 23, 2017 |
May 23, 2017 |
|
- Clinical and Translational Sciences Institute
Minneapolis, Minnesota, United States
|
| 49 |
NCT03332953 |
Recruiting |
Sensory Perception of Sweet Flavors in E-Cigarette |
|
- Other: E-cigarettes with varying concentrations of nicotine & flavor
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Hedonic and Intensity Ratings
|
35 |
All |
18 Years to 29 Years (Adult) |
NCT03332953 |
IRB # 8252 |
|
January 21, 2018 |
July 2018 |
July 2018 |
November 6, 2017 |
March 23, 2018 |
|
- Oregon State University
Corvallis, Oregon, United States
|
| 50 |
NCT03479203 |
Not yet recruiting
New |
Acute Effects of E-Cigarette Aerosol Inhalation |
- Endothelial Dysfunction
- Biochemical Markers
|
- Drug: Electronic Cigarette Aerosol
|
Interventional |
Early Phase 1 |
- University of Pennsylvania
- National Institutes of Health (NIH)
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Changes in serum protein levels (micrograms) of inflammatory biomarkers (HMGB-1, RAGE, ICAM, CRP) in non-smoking healthy subjects before and after electronic cigarette aerosol inhalation.
- Aortic pulse-wave velocity (meters/second)
- Femoral artery flow-mediated dilation (% fractional change in cross-sectional area)
- (and 4 more...)
|
39 |
All |
18 Years to 35 Years (Adult) |
NCT03479203 |
828195
R01HL139358 |
|
March 2018 |
February 2020 |
February 2021 |
March 27, 2018 |
March 27, 2018 |
|
- University of Pennsylvania Perelman School of Medicine
Philadelphia, Pennsylvania, United States
|
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