COVID-19 IgG Formation in Physicians at ALGH and Their Household Members
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|ClinicalTrials.gov Identifier: NCT04540484|
Recruitment Status : Recruiting
First Posted : September 7, 2020
Last Update Posted : September 9, 2020
|Condition or disease|
|Covid19 SARS-CoV Infection Communicable Disease|
|Study Type :||Observational|
|Estimated Enrollment :||900 participants|
|Official Title:||The Prevalence of SARS-CoV-2 IgG Antibody Formation in Physicians at Advocate Lutheran General Hospital and Their Household Members|
|Actual Study Start Date :||August 26, 2020|
|Estimated Primary Completion Date :||September 24, 2021|
|Estimated Study Completion Date :||September 24, 2021|
Attending physicians on the medical staff, fellow physicians, and resident physicians that work at Advocate Lutheran General Hospital (ALGH) from March 1st, 2020 and forward.
Household members above age 18 who lived in household of ALGH physician who tested positive for COVID-19 IgG antibodies, and who lived with that physician for at least 2 consecutive weeks.
- Identifying positive COVID-19 IgG formation [ Time Frame: up to 1 year ]
- Physician Prevalence of COVID-19 serum IgG [ Time Frame: up to 1 year ]The prevalence of COVID-19 serum IgG in physician participants at study entry, 3 months, 6 months, and 12 months after enrollment.
- Household Member Prevalence of COVID-19 serum IgG [ Time Frame: up to 1 year ]The prevalence of COVID-19 serum IgG in household members (as defined above) of physician participants that are positive at the time the associated physician tested positive.
- Physician Risk of Exposure [ Time Frame: up to 1 year ]The differences in prevalence of COVID-19 IgG in physician participants that are deemed to be at minimum, moderate or high risk of COVID-19 exposure.
- Physician and Household Member Transmission [ Time Frame: up to 1 year ]The differences in prevalence of COVID-19 IgG in household members of physician participants that are positive for COVID-19 IgG.
- Asymptomatic Infection [ Time Frame: 1 year ]The correlation between IgG prevalence and previous COVID-19 symptoms - a means of quantifying the presence of asymptomatic carriers amongst the medical staff, an important and heretofore poorly described vector of transmission.
- PPE Use and Positivity [ Time Frame: up to 1 year ]The correlation between the prevalence of seropositivity and adherence to best practices regarding the use of personal protective equipment.
- Antibody Persistence [ Time Frame: up to 1 year ]The development of COVID19 infections in physicians at our hospital over the test period of 12 months, and its correlation to Covid19_IgG positivity. This will allow us to understand the persistence of the antibody and its potential neutralizing power, over time.
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04540484
|Contact: Sigrun Hallmeyer, MDfirstname.lastname@example.org|
|United States, Illinois|
|Advocate Lutheran General Hospital||Recruiting|
|Park Ridge, Illinois, United States, 60068|
|Contact: Katie Wozniak 847-723-2300 email@example.com|
|Principal Investigator: Sigrun Hallmeyer, MD|