COVID-19 in Patients With Anosmia in Egypt
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ClinicalTrials.gov Identifier: NCT04473157 |
Recruitment Status :
Completed
First Posted : July 16, 2020
Last Update Posted : January 15, 2021
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Condition or disease |
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Anosmia Covid19 Dysgeusia |
Fifty Patients presenting to Triage and/or Ear, Nose and Throat (ENT) clinics in Ain Shams University Hospitals with the chief complaint of Anosmia/ dysgeusia in the period July- September 2020; will undergo thorough history taking, clinical assessment and polymers chain reaction rt-PCR to SARS-COV2; and if proven negative to COVID 19, PCR to other respiratory pathogens will be tested. COVID-19 patients will be managed according to the standard protocol of Ain Shams University Hospitals. Follow up after 3 weeks for the outcome of recovery of the smell sense and seroconversion by rapid test for immunoglobulins IgM/ IgG of COVID 19, for the probability of a false negative PCR at initial visit.
Ethical committee approval for the current study protocol was obtained. Patients will be invited to participate and the informed consent will be signed.
Study Type : | Observational |
Actual Enrollment : | 58 participants |
Observational Model: | Case-Only |
Time Perspective: | Prospective |
Official Title: | Detection of SARS-CoV-2 in Patients Presenting With Anosmia During COVID-19 Pandemic Era in Egypt |
Actual Study Start Date : | July 1, 2020 |
Actual Primary Completion Date : | November 30, 2020 |
Actual Study Completion Date : | December 30, 2020 |

- Recovery from Anosmia [ Time Frame: 3 weeks ]subjective questionnaire about smell and taste
- Seroconversion [ Time Frame: 3 weeks ]developing IgM/ IgG antibodies by rapid test
- COVID 19 [ Time Frame: 3 weeks ]developing other symptoms of COVID 19
Biospecimen Retention: Samples Without DNA

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Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- adult (>18 years) patients presented with acute-onset anosmia.
Exclusion Criteria:
- patients with anosmia or gustatory dysfunctions before the epidemic; patients with previous history of chronic sinusitis or previous sinus surgery.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04473157
Egypt | |
Ain Shams University | |
Cairo, Egypt |
Principal Investigator: | Ossama I Mansour, MD | Ain Shams University |
Publications:
Responsible Party: | Ossama Mansour, MD, FACS, Professor of Otolaryngology, Ain Shams University |
ClinicalTrials.gov Identifier: | NCT04473157 |
Other Study ID Numbers: |
FMASU P45a/2020 |
First Posted: | July 16, 2020 Key Record Dates |
Last Update Posted: | January 15, 2021 |
Last Verified: | January 2021 |
Studies a U.S. FDA-regulated Drug Product: | No |
Studies a U.S. FDA-regulated Device Product: | No |
Corona virus SARS-CoV-2 Olfactory Disturbance Taste Disturbance |
COVID-19 Anosmia Dysgeusia Respiratory Tract Infections Infections Pneumonia, Viral Pneumonia Virus Diseases Coronavirus Infections Coronaviridae Infections |
Nidovirales Infections RNA Virus Infections Lung Diseases Respiratory Tract Diseases Olfaction Disorders Sensation Disorders Neurologic Manifestations Nervous System Diseases Taste Disorders |