Working…
COVID-19 is an emerging, rapidly evolving situation.
Get the latest public health information from CDC: https://www.coronavirus.gov.

Get the latest research information from NIH: https://www.nih.gov/coronavirus.
ClinicalTrials.gov
ClinicalTrials.gov Menu

Genetic Basis of COVID-19 Infection

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT04384250
Recruitment Status : Recruiting
First Posted : May 12, 2020
Last Update Posted : May 12, 2020
Sponsor:
Information provided by (Responsible Party):
Ali Sobh, Mansoura University

Brief Summary:
We will study genetic factors causing severe disease due to infection with SARS-COV-2 which may help to find targeted therapy

Condition or disease Intervention/treatment
Genetic Basis of COVID-19 Infection Diagnostic Test: Whole Exome Sequencing

Layout table for study information
Study Type : Observational
Estimated Enrollment : 50 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Genetic Factors Influencing the Response to Infection With SARS-COV-2
Actual Study Start Date : May 10, 2020
Estimated Primary Completion Date : August 31, 2020
Estimated Study Completion Date : May 1, 2021

Intervention Details:
  • Diagnostic Test: Whole Exome Sequencing
    Genetic study of patients


Primary Outcome Measures :
  1. Mutations leading to increase susceptibility to SARS-COV-2 infection [ Time Frame: 12 months ]
    Genetic susceptibility to COVID-19



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Layout table for eligibility information
Ages Eligible for Study:   up to 50 Years   (Child, Adult)
Sexes Eligible for Study:   All
Sampling Method:   Non-Probability Sample
Study Population
COVID-19 positive patients
Criteria

Inclusion Criteria:

  • severe COVID-19 infection

Exclusion Criteria:

  • Comorbidity ((DM, hypertension, Chronic liver or Kidney diseases, HIV, morbid obesity, Malignancy, Immunosuppressive therapy)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04384250


Contacts
Layout table for location contacts
Contact: Ali Sobh, MD +201000911288 ali.sobh@mans.edu.eg
Contact: Marwa Elnagdy, MD +201010645060 marwaelnagdy85@mans.edu.eg

Locations
Layout table for location information
Egypt
Mansoura University Recruiting
Mansoura, Dakahlyia, Egypt, 35516
Contact: Ali Sobh, MD         
Sponsors and Collaborators
Mansoura University
Layout table for additonal information
Responsible Party: Ali Sobh, Lecturer of Pediatric Immunology, Mansoura University
ClinicalTrials.gov Identifier: NCT04384250    
Other Study ID Numbers: RP:20.05.70
First Posted: May 12, 2020    Key Record Dates
Last Update Posted: May 12, 2020
Last Verified: May 2020
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

Layout table for additional information
Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Ali Sobh, Mansoura University:
SARS-COV-2, Genetics
Additional relevant MeSH terms:
Layout table for MeSH terms
Infection
Communicable Diseases