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A Study to Investigate the Effects of Imatinib on Pulmonary Vascular Dysfunction in a Human Model of Lung Injury

This study is currently recruiting participants.
Verified November 2017 by Exvastat Ltd.
Sponsor:
ClinicalTrials.gov Identifier:
NCT03328117
First Posted: November 1, 2017
Last Update Posted: November 17, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
Collaborator:
Parexel
Information provided by (Responsible Party):
Exvastat Ltd.
  Purpose

The study is a randomized, double-blind, placebo-controlled clinical study of imatinib (as mesilate) in healthy subjects exposed inhaled lipopolysaccharide. During the study, eight oral doses of imatinib, or placebo, will each be taken 12 hours apart, before subjects are exposed to nebulized lipopolysaccharide (LPS). Four hours after LPS exposure, a bronchoalveolar lavage (BAL) will be undertaken, and BAL fluid (BALF collected. Once study assessments are completed, a follow-up visit will be conducted approximately 7 days after the last dose of imatinib.

The primary objective of the study is to investigate the effect of imatinib on LPS-induced pulmonary vascular dysfunction. The primary endpoints of this study are:

  1. Change in the number of neutrophils in BALF 6 hours after the LPS challenge in subjects exposed to imatinib compared with placebo.
  2. Change in concentration of total protein in BALF 6 hours after the LPS challenge in subjects exposed to imatinib compared with placebo

Condition Intervention Phase
Acute Lung Injury Drug: Imatinib Drug: Placebo oral capsule Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: A Randomized, Placebo-controlled, Double-blind Study to Investigate the Effects of the Tyrosine Kinase Inhibitor Imatinib on Pulmonary Vascular Dysfunction in a Human Experimental Model of Acute Lung Injury

Resource links provided by NLM:


Further study details as provided by Exvastat Ltd.:

Primary Outcome Measures:
  • Change in the number of neutrophils in bronchoalveolar lavage fluid in subjects exposed to imatinib compared with placebo [ Time Frame: 6 hours after lipopolysaccharide inhalation ]
    Change in the number of neutrophils in bronchoalveolar lavage fluid in subjects exposed to imatinib compared with placebo

  • Change in concentration of total protein in bronchoalveolar lavage fluid in subjects exposed to imatinib compared with placebo [ Time Frame: 6 hours after the LPS challenge ]
    Change in concentration of total protein in bronchoalveolar lavage fluid in subjects exposed to imatinib compared with placebo


Estimated Enrollment: 40
Actual Study Start Date: November 13, 2017
Estimated Study Completion Date: June 2018
Estimated Primary Completion Date: March 2018 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Intervention Drug: Imatinib
Over-encapsulated 100 mg imatinib mesilate tablets
Placebo Comparator: Placebo Drug: Placebo oral capsule
Matching placebo oral capsule

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  1. Are able and willing to provide written informed consent to participate in this clinical study.
  2. Healthy males and females, between 18 and 55 years old (both inclusive) at the screening visit.
  3. Male subjects must practice an acceptable contraceptive method from the time of first IMP administration until 6 weeks after the follow-up visit.
  4. Female subjects must either be:

    1. Of non-childbearing potential:
    2. Or if of childbearing potential, must practice an acceptable contraceptive method from 4 weeks before the first IMP administration until 6 weeks after the follow-up visit.
  5. Good general health as ascertained by detailed medical history and physical examination at the screening visit.
  6. Body mass index ≥18.0 and ≤30 kg/m2 at the screening visit.
  7. No clinically relevant abnormalities in the 12-lead ECG as per the Investigator's judgement at the screening visit
  8. No clinically relevant abnormalities in results of clinical laboratory tests as per the Investigator's judgement at the screening visit.
  9. Normal spirometry (FEV1 ≥ 85% of predicted, FEV1/FVC ratio ≥ 70%) at the screening visit.
  10. Non-smokers or no history of smoking (including e-cigarettes and other forms of vaporizing/inhalation) in the last 6 months prior to the screening visit.
  11. Subjects must be able to communicate well with the Investigator/designee.

Exclusion Criteria:

  1. History of hypersensitivity to the IMP or any of the excipients or to medicinal products with similar chemical structures.
  2. Presence of any clinically relevant acute or chronic disease which could interfere with the subject safety during the study, expose the subject to undue risk, limit the biological sampling, interfere with the absorption of the investigational product (or interfere with the study objectives.
  3. Any history of previous respiratory, hematological or malignant disease, including childhood asthma.
  4. Any history of chronic renal, cardiac (previous myocardial infarction, diagnosis of cardiac failure or cardiac rhythm disturbances such as atrial fibrillation) or hepatic impairment.
  5. Current evidence of ongoing or acute infection, history of repeated or chronic significant infections, or history of serious infection within 3 months of randomization. Acute infection is defined as a history of febrile illness (> 38°C), or 2 or more of the following symptoms within the last 7 days prior to the screening visit or Day 1: cough, sore throat, runny nose, sneezing, limb/joint pain, headache or vomiting/diarrhea.
  6. Any condition that in the opinion of the Investigator will require regular concomitant medication including herbal products, or predicted need of any concomitant medication during the study.
  7. Intake of any prescription and over-the-counter medication (except paracetamol, hormonal contraceptives and hormonal replacement therapy) including herbal and dietary supplements (including St John's Wort), vitamins and minerals, within 7 days or 5 half-lives (whichever is longer) prior to the first dose of IMP.
  8. Systolic blood pressure < 90 mmHg or > 140 mmHg, or diastolic blood pressure < 50 mmHg or > 90 mmHg after 5 minutes in the supine position at the screening visit.
  9. Positive test results for hepatitis B surface antigen (HBsAg), hepatitis C virus antibodies (HCVAb) or human immunodeficiency virus (HIV)-1 and/or -2 antibodies at the screening visit.
  10. Excessive use of caffeine-containing beverages exceeding 500 mg caffeine/day (5 cups of coffee) or intake of food or drinks containing xantine (e.g., caffeine) within 24 hours prior to the screening visit or Day 1.
  11. Positive urine cotinine test at the screening visit or Day 1, or the inability to stop using nicotine-containing products during the clinical study.
  12. History or presence of drug addiction (positive urine drug screen at the screening visit or Day 1).
  13. History of regular alcohol consumption within 6 months of the screening visit defined as an average weekly intake of > 21 units (or an average daily intake of > 3 units) for males or an average weekly intake of > 14 units (or an average daily intake > 2 units) for females.
  14. Positive urine alcohol test at the screening visit or Day 1, or the inability to refrain from the use of alcohol during the clinical study.
  15. Intake of any food or any drinks containing grapefruit, Chinese grapefruit (pomelo), Seville orange (including marmalade) or quinine-containing products (e.g., tonic water, bitter lemon) from 7 days prior to Day 1.
  16. Blood component or plasma donation within 3 months prior to the first dose of IMP.
  17. Participation in another study with an experimental drug within 3 months before the first dose of IMP. Exclusion period starts from last IMP dosed in previous study to first dose of IMP.
  18. Any psychological, emotional problems, any disorders or resultant therapy that is likely to invalidate informed consent, or limited the ability of the subject to comply with the protocol requirements.
  19. Subject is mentally or legally incapacitated.
  20. A pregnant woman or a nursing mother.
  21. Unlikely to comply with the protocol requirements, instructions and study-related restrictions; e.g., uncooperative attitude and improbability of completing the clinical study.
  22. Subjects who, in the opinion of the Investigator, are considered unsuitable for any other reason.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03328117


Contacts
Contact: Charlotte Summers, BM PhD +44 7712 896038 charlotte.summers@exvastat.com
Contact: David Cavalla, PhD david.cavalla@exvastat.com

Locations
United Kingdom
PAREXEL Early Phase Clinical Unit Recruiting
London, United Kingdom
Contact: Muna Albayaty, MBBCh       Muna.Albayaty@parexel.com   
Sponsors and Collaborators
Exvastat Ltd.
Parexel
Investigators
Principal Investigator: Muna Albayaty, MBBCh Parexel
  More Information

Responsible Party: Exvastat Ltd.
ClinicalTrials.gov Identifier: NCT03328117     History of Changes
Other Study ID Numbers: EXV001
2017-002203-10 ( EudraCT Number )
First Submitted: October 24, 2017
First Posted: November 1, 2017
Last Update Posted: November 17, 2017
Last Verified: November 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Product Manufactured in and Exported from the U.S.: No

Additional relevant MeSH terms:
Wounds and Injuries
Lung Injury
Acute Lung Injury
Respiratory Distress Syndrome, Adult
Lung Diseases
Respiratory Tract Diseases
Thoracic Injuries
Respiration Disorders
Imatinib Mesylate
Antineoplastic Agents
Protein Kinase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action