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Trial of CUDC-907 in Children and Young Adults With Relapsed or Refractory Solid Tumors, CNS Tumors, or Lymphoma

This study is currently recruiting participants.
Verified June 2017 by Steven DuBois, Dana-Farber Cancer Institute
Sponsor:
ClinicalTrials.gov Identifier:
NCT02909777
First Posted: September 21, 2016
Last Update Posted: June 27, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
Collaborator:
Curis, Inc.
Information provided by (Responsible Party):
Steven DuBois, Dana-Farber Cancer Institute
  Purpose
This research study is evaluating a novel drug called CUDC-907 as a possible treatment for resistant (refractory) pediatric solid tumors (including neuroblastoma), lymphoma, or brain tumors.

Condition Intervention Phase
Lymphoma Neuroblastoma Brain Tumor Solid Tumor Drug: CUDC-907 Phase 1

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Phase 1 Trial of CUDC-907 in Children and Young Adults With Relapsed or Refractory Solid Tumors, CNS Tumors, or Lymphoma

Resource links provided by NLM:


Further study details as provided by Steven DuBois, Dana-Farber Cancer Institute:

Primary Outcome Measures:
  • Dose Limiting Toxicity [ Time Frame: 2 years ]

Secondary Outcome Measures:
  • Progression Free Survival [ Time Frame: 2 years ]
  • Peak plasma concentration of CUDC-907 in Pediatrics [ Time Frame: 2 years ]
    Determined using standard methods and reported descriptively in aggregate and by assigned dose level.

  • Exposure (AUC) of CUDC-907 in Pediatrics [ Time Frame: 2 years ]
    Determined using standard methods and reported descriptively in aggregate and by assigned dose level.

  • Duration of Response [ Time Frame: 2 years ]
  • Adverse Events per CTCAE Version 4 [ Time Frame: 2 years ]
  • Objective Response [ Time Frame: 2 months ]

Estimated Enrollment: 44
Study Start Date: October 2016
Estimated Study Completion Date: October 2022
Estimated Primary Completion Date: October 2019 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: CUDC-907
  • CUDC-907 orally administered
  • CUDC-907 once daily for 5 consecutive days per week followed by two days without dosing
  • Dose level assigned at registration
  • Pre-dose pharmacokinetic blood sample will be collected
  • Dose escalation will follow a standard 3+3 design
Drug: CUDC-907

Detailed Description:

This is a Phase I clinical trial. A Phase I clinical trial tests the safety of an investigational intervention and also tries to find the best dose of the investigational intervention to use for further studies. "Investigational" means that the intervention is being studied.

The FDA (the U.S. Food and Drug Administration) has not approved CUDC-907 as a treatment option for any disease.

This is the first time that CUDC-907 will be given to children.

In this research study, the investigators are evaluating a new drug, CUDC-907, as a potential new treatment for children with solid tumors, lymphomas and brain tumors. CUDC-907 is an oral drug that blocks certain proteins in tumor cells. These proteins may be important in the growth of some cancers. Laboratory experiments and results from adult studies demonstrate that CUDC-907 may stop tumor growth and, in some cases, cause tumor cells to die. CUDC-907 has been tested in adults with cancer to find out about side effects and dosing in adults. The primary goal of this study is to evaluate side effects of CUDC-907 and find the best dose of CUDC-907 when used in children. Other goals of this study are to determine whether this drug may have benefits against the types of cancer seen in children and to measure the effects of CUDC-907 in the blood.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   1 Year to 21 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Age > 1 years and ≤ 21 years at time of enrollment.
  • Karnofsky performance status ≥ 50% for patients ≥16 years of age and Lansky ≥ 50% for patients <16 years of age (see Appendix A)
  • Diagnosis requirement
  • For Parts A and B, participants must have evaluable or measurable disease (see Section 11).
  • For Part A, participants must have histologically confirmed solid tumors, CNS tumors, or lymphoma based upon biopsy or surgery at initial diagnosis and/or relapse/progression. The only exception to histologic confirmation is for pediatric tumors that are routinely diagnosed exclusively by standard clinical imaging criteria: diffuse intrinsic pontine glioma and optic pathway glioma.
  • For Part B, participants must have one of the following diagnoses histologically confirmed:

    • Neuroblastoma with evidence of Mycn/Myc positivity based on any of the following:

      • MYCN amplification (> 4 copy amplification) from COG reference laboratory or other CLIA-certified laboratory; or
      • Mycn protein expression > 1+ according to validated assay in Children's Hospital Los Angeles (CHLA) Clinical Pathology Laboratory; or
      • Myc expression > 1+ according to validated assay in CHLA Clinical Pathology Laboratory.
    • One of the following mature B cell lymphoma diagnoses:

      • Diffuse large B cell lymphoma
      • Burkitt lymphoma
  • Participants must have disease that is relapsed or refractory and for which standard curative or palliative measures do not exist or are no longer effective.
  • Patients must have fully recovered from the acute toxic effects of all prior anti-cancer therapy except organ function as noted in Section 3.1.6). Patients must meet the following minimum washout periods prior to enrollment:
  • Myelosuppressive chemotherapy: At least 14 days after the last dose of myelosuppressive chemotherapy (42 days for nitrosourea or mitomycin C).
  • Radiotherapy:

    • At least 14 days after local palliative XRT (small port);
    • At least 90 days must have elapsed after prior TBI, craniospinal XRT or if >50% radiation of pelvis;
    • At least 42 must have elapsed if other substantial BM radiation;
    • At least 42 days must have passed since last MIBG or other radionuclide therapy.
  • Small molecule biologic therapy: At least 7 days following the last dose of a biologic agent. For agents with known adverse events occurring beyond 7 days, this duration must be extended beyond the time in which adverse events are known to occur. If extended duration is required, this should be discussed and approved by the study chair.
  • Monoclonal antibody: At least 21 days after the last dose of anitbody
  • Myeloid growth factors: At least 14 days following the last dose of long-acting growth factor (e.g. Neulasta) or 7 days following short-acting growth factor.
  • Stem Cell Infusion or Cellular Therapies: The patient must have no evidence of graft versus host disease and at least 42 days must have elapsed after transplant, stem cell infusion, or cellular therapy.
  • Major Surgery: At least 3 weeks from prior major surgical procedure. Note: Biopsy and central line placement/removal are not considered major.
  • PI3K and HDAC inhibitors: The patient must not have received prior CUDC-907 therapy. Prior treatment with individual PI3K or HDAC inhibitors is allowed. Patients must not have received therapy with the combination of PI3K and HDAC inhibitors.
  • Participants must have normal organ function as defined below.
  • Bone Marrow Function:

    • Absolute neutrophil count ≥1,000/uL
    • Platelets ≥75,000/uL and transfusion independent, defined as not receiving a platelet transfusion for at least 5 days prior to CBC documenting eligibility.
  • Hepatic Function:

    • Total bilirubin ≤ 1.5 x upper limit of normal for age
    • ALT (SGPT) ≤ 135 U/L For the purpose of this study, the ULN for ALT is 45 U/L
    • Serum albumin > 2 g/dL
  • Renal Function:

    --A serum creatinine based on age/gender as follows: Age Maximum Serum Creatinine (mg/dL) Male Female

    1. to < 2 years 0.6 0.6
    2. to < 6 years 0.8 0.8

    6 to < 10 years 1 1 10 to < 13 years 1.2 1.2 13 to < 16 years 1.5 1.4

    ≥ 16 years 1.7 1.4 OR

    --Creatinine clearance ≥ 70 mL/min/1.73 m2 for participants with creatinine levels above institutional normal.

  • Adequate Cardiac Function: QTc < 480 msec
  • Adequate GI Function: Diarrhea < grade 2 by CTCAE version 4
  • Adequate Metabolic Function: Fasting glucose < grade 2 (< 160 mg/dL or < 8.9 mmol/L) without the use of antihyperglycemic agents.
  • Additional Agent-Specific Requirements
  • Patients must be able to swallow either intact capsules or mini-tabs without chewing.
  • In order to limit dose deviations due to rounding, patients must have a body surface area of at least 0.5 m2
  • For patients with CNS tumors (primary or metastatic), any baseline neurologic deficits (including seizure) must be stable for at least one week prior to study enrollment.
  • Ability to understand and/or the willingness of the patient (or parent or legally authorized representative, if minor) to provide informed consent, using an institutionally approved informed consent procedure.

Exclusion Criteria:

  • Patients must not be receiving any of the following concomitant medications:
  • Pharmacologic doses of systemic corticosteroids unless for CNS metastatic or primary disease. For patients with CNS metastatic or primary tumors receiving corticosteroids, they should be on a stable or decreasing dose over the 7 days prior to registration and meet criteria.
  • For all patients, receipt of systemic physiologic replacement steroids, topical and/or inhaled corticosteroids is acceptable.
  • Non-steroidal anti-inflammatory drugs, oral anticoagulants, and therapeutic heparins.
  • Pregnant participants will not be entered on this study given that the effects of CUDC-907 on the developing human fetus are unknown.
  • Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with CUDC-907, breastfeeding mothers are not eligible.
  • Participants of child-bearing or child-fathering potential must agree to use adequate contraception (hormonal birth control; intrauterine device; double barrier method; or total abstinence) throughout their participation, including up until 30 days after last dose of CUDC-907.
  • History of allergic reactions attributed to compounds of similar chemical or biologic composition to CUDC-907.
  • Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements. Note that patients who have had prior allogeneic transplantation are required to have CMV PCR testing performed during screening. A positive screen would be evidence of an active infection and would render the patient ineligible.
  • Patients with a known history of HIV, hepatitis B, and/or hepatitis C (testing not required as part of screening).
  • Patients with a known history of type 1 or type 2 diabetes mellitus.
  • Patients with gastrointestinal disease or disorder that could interfere with absorption of CUDC-907, such as bowel obstruction or inflammatory bowel disease.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02909777


Contacts
Contact: Steven DuBois, MD, MS 617-632-5460 steven_dubois@dfci.harvard.edu

Locations
United States, California
University of California, San Francisco, Benioff Children's Hospital Recruiting
San Francisco, California, United States, 94158
Contact: Kieuhoa Vo, MD    415-476-3831      
Principal Investigator: Kieuhoa Vo, MD         
United States, Massachusetts
Dana Farber Cancer Institute Recruiting
Boston, Massachusetts, United States, 02115
Contact: Steven DuBois, MD, MS    617-632-5460    steven_dubois@dfci.harvard.edu   
Principal Investigator: Steven DuBois, MD, MS         
United States, Pennsylvania
Children's Hospital of Philadelphia Recruiting
Philadelphia, Pennsylvania, United States, 19104
Contact: Elizabeth Fox, MD    267-425-3010    foxe@email.chop.edu   
Principal Investigator: Elizabeth Fox, MD         
United States, Texas
Texas Children's, Baylor College of Medicine Recruiting
Houston, Texas, United States, 77030
Contact: Jodi Muscal, MD    832-824-4632    jamuscal@txch.org   
Principal Investigator: Jodi Muscal, MD         
Sponsors and Collaborators
Dana-Farber Cancer Institute
Curis, Inc.
Investigators
Principal Investigator: Steven DuBois, MD, MS Dana-Farber Cancer Institute
  More Information

Responsible Party: Steven DuBois, MD, Dana-Farber Cancer Institute
ClinicalTrials.gov Identifier: NCT02909777     History of Changes
Other Study ID Numbers: 16-371
First Submitted: September 13, 2016
First Posted: September 21, 2016
Last Update Posted: June 27, 2017
Last Verified: June 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Keywords provided by Steven DuBois, Dana-Farber Cancer Institute:
Lymphoma
Neuroblastoma
Brain Tumor
Solid Tumor

Additional relevant MeSH terms:
Lymphoma
Neoplasms
Brain Neoplasms
Neuroblastoma
Neoplasms by Histologic Type
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases
Central Nervous System Neoplasms
Nervous System Neoplasms
Neoplasms by Site
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumors, Primitive
Neoplasms, Neuroepithelial
Neuroectodermal Tumors
Neoplasms, Germ Cell and Embryonal
Neoplasms, Glandular and Epithelial
Neoplasms, Nerve Tissue