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Functional Imaging of Social Cognition in Premanifest Huntington's Disease (FISCIP)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02551705
Recruitment Status : Unknown
Verified September 2015 by Jan Van den Stock, Universitaire Ziekenhuizen Leuven.
Recruitment status was:  Not yet recruiting
First Posted : September 16, 2015
Last Update Posted : September 16, 2015
Information provided by (Responsible Party):
Jan Van den Stock, Universitaire Ziekenhuizen Leuven

Brief Summary:
Huntington's disease (HD) is a genetic progressive fatal neurodegenerative disorder. In the western world it affects 5-10 persons per 100000. The main brain changes include the loss of brain cells in subcortical structures. The symptoms of HD include involuntary movements, cognitive deterioration and behavioural disturbances. It has been shown that changes in emotion comprehension occur before the onset of the motor symptoms (preHD). This deficit in perception of emotions has been primarily investigated by means of facial expressions. However, emotions can also be expressed through body language. Here, the investigators propose to investigate whether the emotion comprehension deficit in preHD also includes body language comprehension.

Condition or disease Intervention/treatment Phase
Huntington's Disease Other: functional Imaging Not Applicable

Detailed Description:
The investigators will perform a detailed evaluation of body language comprehension abilities in persons that carry the genetic mutation causing HD, but who do not show any movement symptoms yet. In addition, the associated changes in brain structure and function will be studied. The aim is to perform the study with the same group of participants who participated in a recent study carried on by this research group, in which the functional brain changes associated with increased irritability were investigated. This will allow to relate emotion experience with emotion perception. The results of the study may provide a target to further develop therapeutic interventions and aid caregivers of preHD subjects.

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 40 participants
Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: Single (Investigator)
Primary Purpose: Basic Science
Official Title: Functional Imaging of Social Cognition in Premanifest Huntington's Disease
Study Start Date : October 2015
Estimated Primary Completion Date : October 2017
Estimated Study Completion Date : October 2017

Arm Intervention/treatment
Experimental: functional Imaging mutation carrier
Premanifest mutation carrier, behavioral and neural emotional memory processing
Other: functional Imaging
Brain responses associated with emotional memory will be investigated

Active Comparator: functional Imaging non-carrier
non-carrier family member, behavioral and neural emotional memory processing
Other: functional Imaging
Brain responses associated with emotional memory will be investigated

Primary Outcome Measures :
  1. Significant group differences in brain activation for perceiving emotional vs neutral faces by following random effects analyses [ Time Frame: 6 months ]
    Significant group differences in beta-values for the contrast emotional faces vs neutral faces following general linear model parameter estimates

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Huntington's disease positive genotype and non-carrier siblings

Exclusion Criteria:

  • visible chorea
  • MRI contra-indications
  • major neurological/psychiatric comorbidity
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Responsible Party: Jan Van den Stock, Post-doctoral researcher, Universitaire Ziekenhuizen Leuven Identifier: NCT02551705    
Other Study ID Numbers: S58457
First Posted: September 16, 2015    Key Record Dates
Last Update Posted: September 16, 2015
Last Verified: September 2015
Additional relevant MeSH terms:
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Huntington Disease
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Movement Disorders
Heredodegenerative Disorders, Nervous System
Neurodegenerative Diseases
Genetic Diseases, Inborn
Cognition Disorders
Neurocognitive Disorders
Mental Disorders