Gene - Diet Interactions in Fatty Acid Desaturase 1 Gene (FADSDIET)
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ClinicalTrials.gov Identifier: NCT02543216 |
Recruitment Status :
Completed
First Posted : September 7, 2015
Last Update Posted : September 10, 2015
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Condition or disease | Intervention/treatment | Phase |
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Fatty Acid | Dietary Supplement: Sunflower oil | Not Applicable |
Lean and overweight subjects (BMI >20kg/m2 <29kg/m2 ) with CC and TT genotypes of FADS1 polymorphism (rs174547) were recruited from the METSIM study (METabolic Syndrome in Men, currently >10000 men included from the population living in Kuopio). The potential participants were asked to contact study nurse if willing to participate. Twenty six subjects with CC genotype were selected after matching with thirty six subjects with the TT genotype for age, BMI and medication.
Study diet were isocaloric following the habitual diet of the participants with a supplement of 30-50 ml (25-45 g) sunflower oil daily depending on body weight. Thus, approximately 16-28 g (6 E%) LA daily were provided on top of the average intake of approximately 10-12 g (4.5 E%). This dose of sunflower oil is not known to cause any side effects or adverse events and even higher doses have been safe.
Food records were collected at the beginning (4 days) and during the third week of the study (7 days) to estimate daily intake of macronutrients and specifically of different fatty acids.
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 59 participants |
Allocation: | Non-Randomized |
Intervention Model: | Parallel Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Prevention |
Official Title: | Gene - Diet Interactions in Fatty Acid Desaturase 1 Gene (FADSDIET) |
Study Start Date : | January 2015 |
Actual Primary Completion Date : | April 2015 |
Actual Study Completion Date : | April 2015 |

Arm | Intervention/treatment |
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Experimental: CC genotype
4-week study diets were isocaloric following the habitual diet of the participants with a supplement of 30-50 ml (25-45 g) sunflower oil daily depending on body weight. The same diets were instructed for both genotypes.
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Dietary Supplement: Sunflower oil
Study diets were isocaloric following the habitual diet of the participants with a supplement of 30-50 ml (25-45 g) sunflower oil daily depending on body weight. Thus, approximately 16-28 g (6 E%) LA were provided daily on top of the average intake of approximately 10-12 g (4.5 E%). |
Experimental: TT genotype
4-week study diets were isocaloric following the habitual diet of the participants with a supplement of 30-50 ml (25-45 g) sunflower oil daily depending on body weight. The same diets were instructed for both genotypes.
|
Dietary Supplement: Sunflower oil
Study diets were isocaloric following the habitual diet of the participants with a supplement of 30-50 ml (25-45 g) sunflower oil daily depending on body weight. Thus, approximately 16-28 g (6 E%) LA were provided daily on top of the average intake of approximately 10-12 g (4.5 E%). |
- Fatty acid profile of serum lipid fractions [ Time Frame: 4 weeks ]
- Serum lipids an lipoproteins [ Time Frame: 4 weeks ]
- Adipose tissue biopsies [ Time Frame: 4 weeks ]
- white blood cell samples [ Time Frame: 4 weeks ]

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Ages Eligible for Study: | 50 Years to 65 Years (Adult, Older Adult) |
Sexes Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Participant of Metabolic syndrome in men (METSIM) cohort BMI 20-30 kg/m2 Healthy CC/TT genotype (rs 174547)
Exclusion Criteria:
Type 2 diabetes Other chronic disease

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02543216
Finland | |
University of Eastern Finland, Clinical Nutrition | |
Kuopio, Finland, 70211 |
Responsible Party: | Jussi Pihlajamäki, Professor, University of Eastern Finland |
ClinicalTrials.gov Identifier: | NCT02543216 |
Other Study ID Numbers: |
FADSDIET |
First Posted: | September 7, 2015 Key Record Dates |
Last Update Posted: | September 10, 2015 |
Last Verified: | September 2015 |
fatty acids, FADS gene, genotype, diet |