Variable Pressure Support Trial (ViPS)
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|ClinicalTrials.gov Identifier: NCT01769053|
Recruitment Status : Recruiting
First Posted : January 16, 2013
Last Update Posted : August 25, 2016
In 2008 a new ventilation strategy termed variable Pressure Support ventilation (PSV) was introduced, which is able to increase the variability of the respiratory pattern independent from the inspiratory effort. In experimental lung injury, variable PSV was found to improve gas exchange and decrease the inspiratory effort, while reducing alveolar edema and inflammatory infiltration compared to conventional(non-variable) PSV. Importantly, variable PSV reduced peak airway pressure and respiratory system elastance in a variability dependent manner.In addition, preliminary observations suggest that variable PSV can reduce the work of breathing and improve patient comfort, but it is not known whether this new ventilatory strategy is able to speed the weaning from mechanical ventilation.
Since variable PSV can reduce the mean pressure support, it may lead to a faster reduction of pressure support and, therefore, a shorter weaning period than conventional PSV.
The hypothesis of this study is that variable pressure support ventilation reduces the duration of mechanical ventilation to non-variable (conventional) pressure support ventilation.
|Condition or disease||Intervention/treatment||Phase|
|Acute Lung Injury Adult Respiratory Distress Syndrome at Least 24 h of Controlled Mechanical Ventilation||Other: Variable Ventilation||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||228 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||International Multicenter Randomized Controlled Open Trial on Variable vs. Non-Variable Pressure Support for Weaning From Mechanical Ventilation|
|Study Start Date :||January 2013|
|Estimated Primary Completion Date :||August 2017|
|Estimated Study Completion Date :||August 2017|
Active Comparator: Variable Ventilation
Patients are ventilated with variable pressure support mode.
|Other: Variable Ventilation|
No Intervention: Conventional (non-variable) Ventilation
Patients are ventilated with non-variable(conventional) pressure support ventilation mode.
- Weaning time [ Time Frame: From time of randomization until the time of successful extubation, estimated to be up to 30 days ]Weaning time defined as time from randomization to successful extubation.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01769053
|Department of Anesthesiology and Intensive Care, Dresden University of Technology||Recruiting|
|Dresden, Germany, 01307|
|Contact: Thomas Kiss firstname.lastname@example.org|
|Contact: Marcelo Gama de Abreu email@example.com|
|Principal Investigator: Marcelo Gama de Abreu|
|Principal Investigator:||Marcelo Gama de Abreu||Dresden University|