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The complex regional pain syndrom is a weighty disease that often results in a lifelong disability. Mostly this disease appears unilateral after comparatively mundane fractures or operations. In early stages CRPS shows inflammatory processes. These inflammatory components can be seen as edema and vasodilatation. These inflammatory processes lead us to the hypothesis that selective COX-2-inhibitors might help patients with CRPS.
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Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Patients with saved diagnosis of CRPS of the upper extremity based on the current used criteria for diagnosis plus a positiv 3-phase-sceletal-scintilgraphy, if they show pathological PPT-values in QST on the ipsilateral site (Z-values > 2 in age- and gender-based Z-transformation of the raw values)• age ≥ 18 years• Existence of an age-based normal creatinin-clearance (calculated with a defined formula)
Important cardiovascular illness for the purpose of heart failure (NYHA II - IV), coronary heart disease (CHD), peripheral artery occlusive disease (PAOD) or unstable hypertension (values constantly over 140/90 mm Hg)
Florid kidney disease
Neurological systemic disorder (exception: beginning polyneuropathy with normal values of the PPT on the opposite side)
Lesion of the median nerve (ipsi- oder contralateral)
Acute bleeding disease
Known ulcer of the stomach or duodenum
Inflammatory bowel disease
Positive anamnesis of a gastrointestinal bleeding in the last 5 years
Important hepatic dysfunction (Child- pugh > 9)
Hypersensitivity to the agent or to sulfonamides
Known allergy to acetylsalicylic acid, nonsteroidal antiinflammatory drugs or other selectiv cyclooxygenase-inhibitors
Pregnancy and lactation period
Intake of one of the following drugs (current or in the last 3 days)