Benefits and Costs of Home-based Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease (HomeBase)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified July 2012 by La Trobe University.
Recruitment status was:  Recruiting
The Alfred
Austin Health
Monash University
Information provided by (Responsible Party):
Anne Holland, La Trobe University Identifier:
First received: August 11, 2011
Last updated: July 24, 2012
Last verified: July 2012

Pulmonary rehabilitation is an effective treatment for people with chronic obstructive pulmonary disease (COPD) which improves symptoms, reduces hospitalisation and lowers healthcare costs. However less than 1% of Australians with COPD receive pulmonary rehabilitation each year, due to poor access to programs and high levels of disability. This randomised controlled trial will examine the benefits and costs of a novel, entirely home-based pulmonary rehabilitation program for COPD. We hypothesise that home-based pulmonary rehabilitation can deliver equivalent clinical outcomes at lower cost than the centre-based program.

We will randomly allocate 144 people with COPD to undertake either standard pulmonary rehabilitation in a hospital setting, or a low-cost home-based program. Those who undertake pulmonary rehabilitation in the hospital setting will attend the hospital twice each week for eight weeks for supervised exercise training and education. People in the home pulmonary rehabilitation group will receive one home visit and weekly telephone calls for eight weeks, for supervision and mentoring of exercise and provision of education. We will compare the number of people who complete the program in each setting. We will also test whether the groups have similar results for the standard pulmonary rehabilitation outcomes of breathlessness, quality of life and exercise capacity, at the end of the program and 12 months later. We will compare health care costs and personal costs between groups after 12 months.

If home-based pulmonary rehabilitation can improve uptake of this important treatment, deliver good clinical outcomes and reduce costs this will have significant and long-lasting benefits for patients, the community and the health system

Condition Intervention Phase
Chronic Obstructive Pulmonary Disease
Behavioral: Home-based pulmonary rehabilitation
Behavioral: Hospital-based pulmonary rehabilitation
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Benefits and Costs of Home-based Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease

Resource links provided by NLM:

Further study details as provided by La Trobe University:

Primary Outcome Measures:
  • Change in 6-minute walk test [ Time Frame: Baseline, 8 weeks and 12 months ]
    Testing equivalence between groups

Secondary Outcome Measures:
  • Change in Chronic Respiratory Disease Questionnaire [ Time Frame: Baseline, 8 weeks and 12 months ]
  • Change in Modified Medical Research Council Scale [ Time Frame: Baseline, 8 weeks and 12 months ]
  • Cost-effectiveness [ Time Frame: 12 months ]
  • SF-36 v2 [ Time Frame: Baseline, 8 weeks and 12 months ]
    Contributes to cost effectiveness analysis

  • Program completion rate [ Time Frame: 8 weeks ]

Estimated Enrollment: 144
Study Start Date: October 2011
Estimated Study Completion Date: October 2014
Estimated Primary Completion Date: September 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Home-based pulmonary rehabilitation
Home visit plus 8 weeks of once-weekly telephone calls
Behavioral: Home-based pulmonary rehabilitation
One home visit plus weekly telephone calls for 8 weeks
Active Comparator: Hospital-based pulmonary rehabilitation
Standard twice-weekly 8-week outpatient pulmonary rehabilitation program
Behavioral: Hospital-based pulmonary rehabilitation
Standard twice-weekly 8-week outpatient pulmonary rehabilitation program


Ages Eligible for Study:   40 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • current or former smokers of at least 10 packet years
  • aged 40 years or over
  • diagnosis of COPD confirmed on spirometry.

Exclusion Criteria:

  • previous diagnosis of asthma
  • have attended a pulmonary rehabilitation program in the last two years
  • exacerbation of COPD within the last four weeks
  • have comorbidities which prevent participation in an exercise training program
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Please refer to this study by its identifier: NCT01423227

Australia, Victoria
Austin Health
Heidelberg, Victoria, Australia, 3084
Alfred Health
Melbourne, Victoria, Australia, 3004
Sponsors and Collaborators
La Trobe University
The Alfred
Austin Health
Monash University
Principal Investigator: Anne E Holland, PhD La Trobe University, Alfred Health, Institute for Breathing and Sleep
Principal Investigator: Christine F McDonald, PhD Austin Health, Institute for Breathing and Sleep
Principal Investigator: Ajay Mahal, PhD Monash University
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Anne Holland, Associate Professor, La Trobe University Identifier: NCT01423227     History of Changes
Other Study ID Numbers: HomeBase 
Study First Received: August 11, 2011
Last Updated: July 24, 2012

Keywords provided by La Trobe University:
quality of life
economic evaluation

Additional relevant MeSH terms:
Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Respiratory Tract Diseases processed this record on January 23, 2017