Mutational Profiling in Colorectal Tumors to Determine Its Role in the Diagnosis, Prognostic Significance and Their Impact in Clinical Management
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|ClinicalTrials.gov Identifier: NCT01371942|
Recruitment Status : Unknown
Verified June 2011 by Taipei Medical University WanFang Hospital.
Recruitment status was: Active, not recruiting
First Posted : June 13, 2011
Last Update Posted : June 13, 2011
|Condition or disease|
The following are items corresponding to the critical tasks of the project.
- Collect, annotate, and store fresh endoscopic specimens of suspicious abnormal tissue (premalignant lesions and primary tumors for genetic mutational investigation;
- Collect, annotate, and store fresh specimens from metastatic lesions (e.g.: hepatic metastatic tumors), under sonographic or other imaging modalities guided biopsy procedures;
- Collect, process, and store serum, plasma and isolate lymphocytes from blood drawn from patients with colorectal tumor;
- Establish a database to link materials acquisition, pathologic, and clinical information on patients who participate in the protocol;
- To utilize the clinical database to perform clinical and pathological correlation with the results of current and future scientific studies;
- To evaluate genomic and biochemical alterations in colorectal tumors.
- To test the effect of small molecule inhibitors on the activation of wild-type and mutant genetic alterations and/or other potential molecular targets.
- To correlate tumor genotype and signaling abnormalities with clinical response to genetic alterations and/or other potential molecular targets inhibitors
- Analysis of laboratory findings in relationship to patient demographics and clinical course.
|Study Type :||Observational|
|Estimated Enrollment :||300 participants|
|Official Title:||Mutational Profiling in Colorectal Tumors to Determine Its Role in the Diagnosis, Prognostic Significance and Their Impact in Clinical Management|
|Study Start Date :||May 2010|
|Estimated Study Completion Date :||May 2013|
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01371942
|Taipei Medical University - WanFang Hospital|
|Principal Investigator:||Gi-Shih Lien||Taipei Medical University WanFang Hospital|