Mutational Profiling in Colorectal Tumors to Determine Its Role in the Diagnosis, Prognostic Significance and Their Impact in Clinical Management
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|ClinicalTrials.gov Identifier: NCT01371942|
Recruitment Status : Unknown
Verified June 2011 by Taipei Medical University WanFang Hospital.
Recruitment status was: Active, not recruiting
First Posted : June 13, 2011
Last Update Posted : June 13, 2011
|Condition or disease|
The following are items corresponding to the critical tasks of the project.
- Collect, annotate, and store fresh endoscopic specimens of suspicious abnormal tissue (premalignant lesions and primary tumors for genetic mutational investigation;
- Collect, annotate, and store fresh specimens from metastatic lesions (e.g.: hepatic metastatic tumors), under sonographic or other imaging modalities guided biopsy procedures;
- Collect, process, and store serum, plasma and isolate lymphocytes from blood drawn from patients with colorectal tumor;
- Establish a database to link materials acquisition, pathologic, and clinical information on patients who participate in the protocol;
- To utilize the clinical database to perform clinical and pathological correlation with the results of current and future scientific studies;
- To evaluate genomic and biochemical alterations in colorectal tumors.
- To test the effect of small molecule inhibitors on the activation of wild-type and mutant genetic alterations and/or other potential molecular targets.
- To correlate tumor genotype and signaling abnormalities with clinical response to genetic alterations and/or other potential molecular targets inhibitors
- Analysis of laboratory findings in relationship to patient demographics and clinical course.
|Study Type :||Observational|
|Estimated Enrollment :||300 participants|
|Official Title:||Mutational Profiling in Colorectal Tumors to Determine Its Role in the Diagnosis, Prognostic Significance and Their Impact in Clinical Management|
|Study Start Date :||May 2010|
|Estimated Study Completion Date :||May 2013|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01371942
|Taipei Medical University - WanFang Hospital|
|Principal Investigator:||Gi-Shih Lien||Taipei Medical University WanFang Hospital|