ClinicalTrials.gov
ClinicalTrials.gov Menu

The Effect of Metformin on the Correlation Between Hyperinsulinemia and Hypertension

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01342614
Recruitment Status : Completed
First Posted : April 27, 2011
Last Update Posted : May 13, 2011
Sponsor:
Information provided by:
China-Japan Friendship Hospital

Brief Summary:
The objective of this study is to investigate the effect of metformin on the correlation between hyperinsulinemia and hypertension.

Condition or disease Intervention/treatment Phase
Diabetes Mellitus Essential Hypertension Drug: Fosinopril Drug: Metformin Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 140 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: The Effect of Metformin on the Correlation Between Hyperinsulinemia and Hypertension
Study Start Date : May 2006
Actual Primary Completion Date : August 2009
Actual Study Completion Date : August 2009

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Active Comparator: Fosinopril group
Fosinopril group received fosinopril, 10mg, once per day.
Drug: Fosinopril
Fosinopril group received fosinopril, 10mg, once per day.

Experimental: Metformin group
Metformin group was treated with metformin hydrochloride, 500mg, three times per day
Drug: Metformin
Metformin group was treated with metformin hydrochloride, 500mg, three times per day




Primary Outcome Measures :
  1. Blood pressure measurement [ Time Frame: 8 weeks ]


Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   20 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • 20 to 65 years of age, regardless of sex
  • duration of hypertension was <5 years
  • overweight or obesity, mild to moderate hypertension, receive no euglycemic agent or antiobesity drug

Responsible Party: Prof. LI Guangwei, China-Japan Friendship Hospital
ClinicalTrials.gov Identifier: NCT01342614     History of Changes
Other Study ID Numbers: MET140
First Posted: April 27, 2011    Key Record Dates
Last Update Posted: May 13, 2011
Last Verified: November 2005

Keywords provided by China-Japan Friendship Hospital:
Hypertension
Insulin Resistance
Hyperinsulinemia
Metformin
Fosinopril

Additional relevant MeSH terms:
Diabetes Mellitus
Hypertension
Hyperinsulinism
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Vascular Diseases
Cardiovascular Diseases
Metformin
Fosinopril
Hypoglycemic Agents
Physiological Effects of Drugs
Angiotensin-Converting Enzyme Inhibitors
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Antihypertensive Agents