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The Effect of Metformin on the Correlation Between Hyperinsulinemia and Hypertension

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01342614
First Posted: April 27, 2011
Last Update Posted: May 13, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
China-Japan Friendship Hospital
  Purpose
The objective of this study is to investigate the effect of metformin on the correlation between hyperinsulinemia and hypertension.

Condition Intervention
Diabetes Mellitus Essential Hypertension Drug: Fosinopril Drug: Metformin

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: The Effect of Metformin on the Correlation Between Hyperinsulinemia and Hypertension

Resource links provided by NLM:


Further study details as provided by China-Japan Friendship Hospital:

Primary Outcome Measures:
  • Blood pressure measurement [ Time Frame: 8 weeks ]

Enrollment: 140
Study Start Date: May 2006
Study Completion Date: August 2009
Primary Completion Date: August 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Fosinopril group
Fosinopril group received fosinopril, 10mg, once per day.
Drug: Fosinopril
Fosinopril group received fosinopril, 10mg, once per day.
Experimental: Metformin group
Metformin group was treated with metformin hydrochloride, 500mg, three times per day
Drug: Metformin
Metformin group was treated with metformin hydrochloride, 500mg, three times per day

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • 20 to 65 years of age, regardless of sex
  • duration of hypertension was <5 years
  • overweight or obesity, mild to moderate hypertension, receive no euglycemic agent or antiobesity drug
  Contacts and Locations
No Contacts or Locations Provided
  More Information

Responsible Party: Prof. LI Guangwei, China-Japan Friendship Hospital
ClinicalTrials.gov Identifier: NCT01342614     History of Changes
Other Study ID Numbers: MET140
First Submitted: April 26, 2011
First Posted: April 27, 2011
Last Update Posted: May 13, 2011
Last Verified: November 2005

Keywords provided by China-Japan Friendship Hospital:
Hypertension
Insulin Resistance
Hyperinsulinemia
Metformin
Fosinopril

Additional relevant MeSH terms:
Hypertension
Diabetes Mellitus
Hyperinsulinism
Vascular Diseases
Cardiovascular Diseases
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Metformin
Fosinopril
Hypoglycemic Agents
Physiological Effects of Drugs
Angiotensin-Converting Enzyme Inhibitors
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Antihypertensive Agents