This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

Leucine Supplementation and Skeletal Muscle Disuse

This study has been completed.
Information provided by (Responsible Party):
Humberto Nicastro, University of Sao Paulo Identifier:
First received: August 30, 2010
Last updated: February 22, 2013
Last verified: February 2013
Leucine supplementation is widely known for promoting strong influence on skeletal muscle remodeling. This study aims to evaluate the effect of leucine supplementation on disuse-induced skeletal muscle atrophy.

Condition Intervention
Disuse Atrophy Dietary Supplement: Leucine Dietary Supplement: Placebo

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
Official Title: Leucine and Skeletal Muscle Disuse: Clinical Anti-Atrophic Effectiveness and Related Mechanisms

Resource links provided by NLM:

Further study details as provided by Humberto Nicastro, University of Sao Paulo:

Primary Outcome Measures:
  • Skeletal muscle structure (cross-sectional area) [ Time Frame: 2 weeks ]

Secondary Outcome Measures:
  • Molecular signalling pathways (hypertrophy, atrophy, and inflammation) [ Time Frame: 2 weeks ]

Enrollment: 22
Study Start Date: April 2011
Study Completion Date: February 2013
Primary Completion Date: February 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Immobilization and Leucine Dietary Supplement: Leucine
7.2 g of leucine during 2 weeks
Placebo Comparator: Immobilization and Placebo Dietary Supplement: Placebo
7.2 g of alanine during 2 weeks


Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Clinical diagnosis of anterior cruciate ligament injury
  • Physically active
  • Must be able to swallow tablets
  • Non-smokers
  • Do not use nutritional supplements

Exclusion Criteria:

  • Post-surgical complications
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01192009

University of São Paulo - School of Physical Education and Sports
São Paulo, Brazil, 05508-030
Sponsors and Collaborators
University of Sao Paulo
Principal Investigator: Humberto Nicastro, PhD Student University of São Paulo
  More Information

Responsible Party: Humberto Nicastro, PhD, University of Sao Paulo Identifier: NCT01192009     History of Changes
Other Study ID Numbers: 2009/02896-6
Study First Received: August 30, 2010
Last Updated: February 22, 2013

Keywords provided by Humberto Nicastro, University of Sao Paulo:
Skeletal Muscle Disuse

Additional relevant MeSH terms:
Muscular Disorders, Atrophic
Pathological Conditions, Anatomical
Muscular Diseases
Musculoskeletal Diseases
Neuromuscular Diseases
Nervous System Diseases processed this record on August 17, 2017