Developmental Pathways to Health and Disease: Metabolic, Neurodevelopmental and Related Outcomes. (GUSTO)
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|ClinicalTrials.gov Identifier: NCT01174875|
Recruitment Status : Active, not recruiting
First Posted : August 4, 2010
Last Update Posted : February 8, 2017
This study aims to test the following two hypotheses in women recruited in early pregnancy and whose children will be followed up till at least 9 years of age.
- Epigenetic changes in conceptual tissues obtained at birth reflect the environment that the fetus was exposed to during development.
- The pattern of epigenetic marks in gene promoters obtained from DNA in birth tissues, together with genotype, phenotype, and environmental exposures, can be utilized to assess how the perinatal environment affects subsequent metabolic, neurodevelopmental and other phenotypes.
|Condition or disease|
|Metabolic Diseases Neurological and Mental Health Conditions|
|Study Type :||Observational|
|Actual Enrollment :||1247 participants|
|Official Title:||Growing Up in Singapore Towards Healthy Outcomes|
|Study Start Date :||June 2009|
|Estimated Primary Completion Date :||June 2020|
|Estimated Study Completion Date :||June 2020|
Pregnant mothers, infants and children
Women in their early pregnancy who are attending the first trimester antenatal ultrasound scan at the public maternity units at KK Women's and Children's Hospital (KKH) and National University Hospital (NUH). Only women age 18 years and above who are Singapore Citizens or Singapore Permanent Residents. Participants have to intend to eventually deliver in NUH or KKH and to reside in Singapore for the next 5 years. Willingness to donate cord, cord blood and placenta. The fetus should be racially homogenous with both sets of grandparents of the same ethnicity. Babies born from these mothers will be followed up until the child is at least 9 years of age.
- Roles of fetal, developmental and epigenetic factors in pathways to disease [ Time Frame: Perinatal ]To evaluate the role of fixed genetic risk variants, modifiable epigenetic markers, circulating metabolites and hormones in blood, and host-microbe interactions which can reflect past developmental influences, and in association with other factors, affect future trajectories of development and its relationship to NCDs.
- Influence of prenatal and early postnatal factors on child health [ Time Frame: During pregnancy and infancy period ]To examine the role of maternal nutrition, lifestyle, emotional health, and other environmental factors in infancy that can influence the development of phenotypes in childhood which confer risk for later metabolic and mental disorders.
- Effect of factors in pregnancy and early postpartum period on maternal health [ Time Frame: During pregnancy and postpartum period ]To examine the role of maternal nutrition, lifestyle, emotional health, and other environmental factors in pregnancy or postpartum period that can influence future maternal risk of metabolic disorders, including body weight changes.
Biospecimen Retention: Samples With DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01174875
|National University Hospital|
|Principal Investigator:||Yap-Seng Chong||National University Health System|