Apelin Levels and G212A Polymorphism of Apelin Receptor (APJ)
The aim of this study is to investigate serum apelin levels as well as their possible association with G212A polymorphism of the apelin receptor in obese children and adolescents.
So far apelin has been reported to be involved in the pathophysiology of various heart diseases such as cardiomyopathies and heart failure. According to recent reports in adults apelin seems to be associated with impaired glucose metabolism, particularly in newly diagnosed diabetes type 2 patients. Obesity is associated with insulin resistance and compensatory hyperinsulinemia leading to diabetes mellitus type 2 even in youngsters. The researchers will try to investigate the role of this new adipokine in order to early detect and to prevent similar entities in childhood obesity.
Diabetes Mellitus Type 2
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Serum Apelin Levels and G212A Polymorphism of Apelin Receptor (APJ)in Obese Children and Adolescents.|
- Serum Apelin Levels [ Time Frame: First day after enrollment and after 8-hours of night fasting, at approximately 8:00 pm in the morning ]Apelin levels were measured in serum of participants, in fasting state
- Frequency of G212A Polymorphism of Apelin Receptor in Obese Children and Adolescents [ Time Frame: First day after enrollment ]Number of participants with Apelin Receptor Gene G212A polymorphism by genotype group
|Study Start Date:||May 2010|
|Study Completion Date:||January 2014|
|Primary Completion Date:||June 2012 (Final data collection date for primary outcome measure)|
obese subjects according to International Obesity Task Force criteria
Please refer to this study by its ClinicalTrials.gov identifier: NCT01121172
|Unit of Pediatric Endocrinology, Diabetes and Metabolism-4th Department of Pediatrics, Medical School of Aristotle University of Thessaloniki|
|Thessaloniki, Greece, 56403|