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The Effects of Riboflavin/ Ultraviolet-A Corneal Cross-linking on the Signs and Symptoms of Bullous Keratopathy (C3R)

This study has been completed.
Information provided by:
Mashhad University of Medical Sciences Identifier:
First received: April 16, 2010
Last updated: NA
Last verified: October 2008
History: No changes posted
Recently, riboflavin (0.1%) and ultraviolet-A (UVA) collagen cross-linking (C3R) has shown potential to improve the signs and symptoms of bullous keratopathy .The objective of this study is to demonstrate the effects of C3R to treat bullous keratopathy.

Condition Intervention
Bullous Keratopathy Radiation: ultraviolet-A

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Study of the Effects of Riboflavin/ Ultraviolet-A Corneal Cross-linking

Resource links provided by NLM:

Further study details as provided by Mashhad University of Medical Sciences:

Enrollment: 20
Study Start Date: November 2008
Study Completion Date: September 2009
Intervention Details:
    Radiation: ultraviolet-A
    Corneal cross linking (C3R) with riboflavin and ultraviolet-A (UVA, 370 nm, 3mW/cm2) for 30 min

Ages Eligible for Study:   20 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • patients with bollous keratopathy

Exclusion Criteria:

  • corneal scarring or contemporary eye disease affecting VA were excluded.
  Contacts and Locations
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No Contacts or Locations Provided
  More Information Identifier: NCT01106274     History of Changes
Other Study ID Numbers: MUMS-88191
Study First Received: April 16, 2010
Last Updated: April 16, 2010

Additional relevant MeSH terms:
Corneal Edema
Corneal Diseases
Eye Diseases
Vitamin B Complex
Growth Substances
Physiological Effects of Drugs
Photosensitizing Agents
Dermatologic Agents processed this record on August 18, 2017