Impact of Spices and Herbs on Endothelial Function
![]() |
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT01085019 |
Recruitment Status
:
Completed
First Posted
: March 11, 2010
Last Update Posted
: June 28, 2012
|
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Endothelial Function | Dietary Supplement: Cinnamon Dietary Supplement: Oregano Dietary Supplement: Ginger Dietary Supplement: Rosemary Dietary Supplement: Black pepper Dietary Supplement: Placebo | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 224 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Double (Participant, Care Provider) |
Primary Purpose: | Prevention |
Official Title: | Investigation of the Impact of Spices and Herbs on Endothelial Function and Other CVD Risk Factors in Men and Women. |
Study Start Date : | March 2010 |
Actual Primary Completion Date : | June 2011 |
Actual Study Completion Date : | December 2011 |
Arm | Intervention/treatment |
---|---|
Experimental: Dietary supplement: Cinnamon |
Dietary Supplement: Cinnamon
2.8g/day of cinnamon in capsules during 4 weeks.
|
Experimental: Dietary supplement: Oregano |
Dietary Supplement: Oregano
2.8g/day of oregano in capsules during 4 weeks.
|
Experimental: Dietary supplement: Ginger |
Dietary Supplement: Ginger
2.8g/day of ginger in capsules during 4 weeks.
|
Experimental: Dietary supplement: Rosemary |
Dietary Supplement: Rosemary
2.8g/day of rosemary in capsules during 4 weeks.
|
Experimental: Dietary supplement: Black pepper |
Dietary Supplement: Black pepper
2.8g/day of black pepper in capsules for 4 weeks.
|
Placebo Comparator: Dietary supplement: Placebo |
Dietary Supplement: Placebo
2.8 g/day of placebo in capsules (corn starch) during 4 weeks.
|
- Endothelial function measured by endopat system (the endothelium-mediated changes in vacular tone) [ Time Frame: at week 0 and week 4 ]
- Circulating level of plasma lipoproteins-lipids [ Time Frame: at week 0 and week 4 ]
- Oxidative stress [ Time Frame: at week 0 and week 4 ]
- Endothelial activation and inflammatory markers [ Time Frame: at week 0 and week 4 ]

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 40 Years to 70 Years (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Age 40-70 yrs
- Men and postmenopausal women
- Waist girth >102cm (men) or >88cm (women)
- LDL-C > 2.8 mmol/L
- Framingham 10‐yr risk score < 10%
- Marginal endothelial dysfunction
- Non smoker
Exclusion Criteria:
- Medication for lipid, hypertension, diabetes
- History of CVD, diabetes, other endocrines disorders
- Pre‐menopausal women
- Alcohol consumption > 1 drink per day
- Unusual dietary habits (e.g. vegetarism)
- Chronic use of supplements (estrogens, vitamins, minerals or flavonoids)
- Aversion or intolerance for spices and/or herbs
- Injury to fingers or amrs that would interfere with endothelial function measurement

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01085019
Canada, Manitoba | |
Richardson Centre of Functional Foods and Nutracuticals | |
Winnipeg, Manitoba, Canada, R3T 6C5 | |
Canada, Quebec | |
Institute of Nutraceuticals and Functional Foods | |
Quebec City, Quebec, Canada, G1V 0A6 |
Principal Investigator: | Charles Couillard, Ph.D | Laval University |
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | Charles Couillard, Professor, Laval University |
ClinicalTrials.gov Identifier: | NCT01085019 History of Changes |
Other Study ID Numbers: |
INAF-2009-253 |
First Posted: | March 11, 2010 Key Record Dates |
Last Update Posted: | June 28, 2012 |
Last Verified: | June 2012 |
Keywords provided by Charles Couillard, Laval University:
Endothelial function Cardiovascular risk factors Spices Herbs Antioxidant |