Impact of Spices and Herbs on Endothelial Function
|ClinicalTrials.gov Identifier: NCT01085019|
Recruitment Status : Completed
First Posted : March 11, 2010
Last Update Posted : June 28, 2012
|Condition or disease||Intervention/treatment|
|Endothelial Function||Dietary Supplement: Cinnamon Dietary Supplement: Oregano Dietary Supplement: Ginger Dietary Supplement: Rosemary Dietary Supplement: Black pepper Dietary Supplement: Placebo|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||224 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Care Provider)|
|Official Title:||Investigation of the Impact of Spices and Herbs on Endothelial Function and Other CVD Risk Factors in Men and Women.|
|Study Start Date :||March 2010|
|Primary Completion Date :||June 2011|
|Study Completion Date :||December 2011|
|Experimental: Dietary supplement: Cinnamon||
Dietary Supplement: Cinnamon
2.8g/day of cinnamon in capsules during 4 weeks.
|Experimental: Dietary supplement: Oregano||
Dietary Supplement: Oregano
2.8g/day of oregano in capsules during 4 weeks.
|Experimental: Dietary supplement: Ginger||
Dietary Supplement: Ginger
2.8g/day of ginger in capsules during 4 weeks.
|Experimental: Dietary supplement: Rosemary||
Dietary Supplement: Rosemary
2.8g/day of rosemary in capsules during 4 weeks.
|Experimental: Dietary supplement: Black pepper||
Dietary Supplement: Black pepper
2.8g/day of black pepper in capsules for 4 weeks.
|Placebo Comparator: Dietary supplement: Placebo||
Dietary Supplement: Placebo
2.8 g/day of placebo in capsules (corn starch) during 4 weeks.
- Endothelial function measured by endopat system (the endothelium-mediated changes in vacular tone) [ Time Frame: at week 0 and week 4 ]
- Circulating level of plasma lipoproteins-lipids [ Time Frame: at week 0 and week 4 ]
- Oxidative stress [ Time Frame: at week 0 and week 4 ]
- Endothelial activation and inflammatory markers [ Time Frame: at week 0 and week 4 ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01085019
|Richardson Centre of Functional Foods and Nutracuticals|
|Winnipeg, Manitoba, Canada, R3T 6C5|
|Institute of Nutraceuticals and Functional Foods|
|Quebec City, Quebec, Canada, G1V 0A6|
|Principal Investigator:||Charles Couillard, Ph.D||Laval University|