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Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors

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ClinicalTrials.gov Identifier: NCT00919750
Recruitment Status : Completed
First Posted : June 12, 2009
Last Update Posted : July 16, 2018
Sponsor:
Collaborator:
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Children's Oncology Group

Brief Summary:
The purpose of this study is to collect and store brain tissue samples and blood from children with brain cancer that will be tested in the laboratory. Collecting and storing samples of tumor tissue and blood from patients to test in the laboratory may help the study of cancer in the future.

Condition or disease Intervention/treatment
Childhood Atypical Teratoid/Rhabdoid Tumor Childhood Central Nervous System Germ Cell Tumor Childhood Cerebral Anaplastic Astrocytoma Childhood Cerebral Astrocytoma Childhood Choroid Plexus Neoplasm Childhood Craniopharyngioma Childhood Grade I Meningioma Childhood Grade II Meningioma Childhood Grade III Meningioma Childhood Infratentorial Ependymoma Childhood Oligodendroglioma Childhood Supratentorial Ependymoma Ependymoma Newly Diagnosed Childhood Ependymoma Recurrent Childhood Cerebellar Astrocytoma Recurrent Childhood Cerebral Astrocytoma Recurrent Childhood Ependymoma Recurrent Childhood Medulloblastoma Recurrent Childhood Supratentorial Embryonal Tumor, Not Otherwise Specified Recurrent Childhood Visual Pathway Glioma Other: Cytology Specimen Collection Procedure

Detailed Description:

OBJECTIVES:

I. Collect brain tumor tissue and an accompanying blood sample from pediatric patients with brain tumors treated at Children?s Oncology Group institutions.

II. Provide a repository for long-term storage of specimens from these patients.

III. Make these specimens available to qualified researchers to understand the biology of pediatric brain tumors.

OUTLINE: This is a multicenter study.

Brain tumor tissue and blood specimens are collected from patients and banked for future study.


Study Type : Observational
Actual Enrollment : 1258 participants
Official Title: A Children's Oncology Group Protocol for Collecting and Banking Pediatric Brain Tumor Research Specimens
Actual Study Start Date : February 16, 2004
Actual Primary Completion Date : June 30, 2018
Actual Study Completion Date : June 30, 2018


Group/Cohort Intervention/treatment
Ancillary-Correlative (tissue and blood sample collection)
Brain tumor tissue and blood specimens are collected from patients and banked for future study.
Other: Cytology Specimen Collection Procedure
Correlative studies
Other Name: Cytologic Sampling




Primary Outcome Measures :
  1. Collection of brain tumor tissue and an accompanying blood sample from pediatric patients with brain tumors treated at Children?s Oncology Group institutions [ Time Frame: Up to 16 years ]
  2. Creation of a repository for long-term storage of these specimens [ Time Frame: Up to 16 years ]
  3. Making these specimens available to qualified researchers to understand the biology of pediatric brain tumors [ Time Frame: Up to 16 years ]


Information from the National Library of Medicine

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Ages Eligible for Study:   up to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Criteria

Inclusion Criteria:

  • Diagnosis of brain tumor
  • Previously treated at a Children?s Oncology Group (COG) institution

    • Patients are eligible at time of diagnosis, second-look surgery, recurrence, or development of a second malignant neoplasm
  • Must have brain tumor biological specimens derived from primary tumors of the CNS available for submission

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00919750


  Show 187 Study Locations
Sponsors and Collaborators
Children's Oncology Group
National Cancer Institute (NCI)
Investigators
Principal Investigator: Scott Pomeroy Children's Oncology Group

Responsible Party: Children's Oncology Group
ClinicalTrials.gov Identifier: NCT00919750     History of Changes
Obsolete Identifiers: NCT00228748
Other Study ID Numbers: ACNS02B3
NCI-2009-00334 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
COG-ACNS02B3
CDR0000352347
ACNS02B3 ( Other Identifier: Childrens Oncology Group )
ACNS02B3 ( Other Identifier: CTEP )
U10CA098543 ( U.S. NIH Grant/Contract )
UG1CA189958 ( U.S. NIH Grant/Contract )
First Posted: June 12, 2009    Key Record Dates
Last Update Posted: July 16, 2018
Last Verified: July 2018

Additional relevant MeSH terms:
Neoplasms
Brain Neoplasms
Neoplasms, Germ Cell and Embryonal
Astrocytoma
Ependymoma
Oligodendroglioma
Meningioma
Medulloblastoma
Craniopharyngioma
Adamantinoma
Rhabdoid Tumor
Optic Nerve Glioma
Choroid Plexus Neoplasms
Central Nervous System Neoplasms
Nervous System Neoplasms
Neoplasms by Site
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neoplasms by Histologic Type
Glioma
Neoplasms, Neuroepithelial
Neuroectodermal Tumors
Neoplasms, Glandular and Epithelial
Neoplasms, Nerve Tissue
Neoplasms, Vascular Tissue
Meningeal Neoplasms
Neuroectodermal Tumors, Primitive
Bone Neoplasms
Bone Diseases