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The Cardiovascular Benefits of Reducing Personal Exposure to Air Pollution

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ClinicalTrials.gov Identifier: NCT00809432
Recruitment Status : Completed
First Posted : December 17, 2008
Last Update Posted : December 17, 2008
Sponsor:
Collaborator:
Peking Union Medical College
Information provided by:
University of Edinburgh

Brief Summary:
Exposure to air pollution is an important risk factor for cardiovascular morbidity and mortality, and is associated with increased blood pressure, reduced heart rate variability, endothelial dysfunction and myocardial ischaemia. The study objectives were to assess the potential cardiovascular benefits of reducing personal particulate air pollution exposure by wearing a facemask in healthy volunteers.

Condition or disease Intervention/treatment Phase
Blood Pressure Heart Rate Variability Device: Face mask (Dust Respirator) Other: No Face mask Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 15 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Beneficial Cardiovascular Effects of Reducing Exposure to Particulate Air Pollution With a Simple Facemask
Study Start Date : August 2008
Actual Primary Completion Date : August 2008
Actual Study Completion Date : August 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Air Pollution

Arm Intervention/treatment
Experimental: Visit 1
2 hour city centre kerbside walk in Beijing China
Other: No Face mask
Subjects will not wear a face mask to reduce their personal exposure to air pollution

Experimental: Visit 2
2 hour city centre kerbside walk in Beijing China
Device: Face mask (Dust Respirator)
Subjects to wear a simple face mask for 24 hours prior to the study day and the 24 hours of the study day. They will be instructed to wear the mask as much as possible when indoors and at all times when outdoors.
Other Name: 3M Dust Respirator 8812




Primary Outcome Measures :
  1. Ambulatory blood pressure [ Time Frame: During 24 hour study period ]

Secondary Outcome Measures :
  1. Heart rate [ Time Frame: During 24 hour study period ]
  2. Heart rate variability [ Time Frame: During 24 hour study period ]
  3. Personal air pollution exposure [ Time Frame: During 2 hour city centre walk ]


Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy volunteers

Exclusion Criteria:

  • Current smokers
  • Significant occupational exposure to air pollution
  • Regular medication use (except oral contraceptive pill)
  • Intercurrent illness

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00809432


Locations
China
Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Medical Union College
Beijing, China
Sponsors and Collaborators
University of Edinburgh
Peking Union Medical College
Investigators
Principal Investigator: Jeremy P Langrish, MB BCh MRCP University of Edinburgh

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Professor David E Newby, University of Edinburgh
ClinicalTrials.gov Identifier: NCT00809432     History of Changes
Other Study ID Numbers: 167/2008/Pilot
First Posted: December 17, 2008    Key Record Dates
Last Update Posted: December 17, 2008
Last Verified: December 2008

Keywords provided by University of Edinburgh:
Air pollution
Heart rate
Heart rate variability
Blood pressure
Face mask