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Intramuscular Lipid and Insulin Action:Ethnic Aspects (QuEST)

This study has been completed.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Information provided by (Responsible Party):
Barbara Gower, University of Alabama at Birmingham Identifier:
First received: July 29, 2008
Last updated: June 14, 2012
Last verified: June 2012
High levels of the hormone insulin are associated with risk for heart disease and diabetes, and may make it hard to lose weight. The types of food eaten may affect insulin levels. The purpose of this study is to determine if manipulation of dietary carbohydrate content improves insulin sensitivity (Si), augments weight loss, and promotes weight loss maintenance in healthy adults.

Condition Intervention
Dietary Supplement: Low carbohydrate

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Participant)
Primary Purpose: Basic Science
Official Title: Intramuscular Lipid and Insulin Action:Ethnic Aspects

Resource links provided by NLM:

Further study details as provided by University of Alabama at Birmingham:

Primary Outcome Measures:
  • Insulin sensitivity [ Time Frame: IVGTT and minimal model ]

Secondary Outcome Measures:
  • Weight loss [ Time Frame: Weight loss over 8 weeks ]

Enrollment: 69
Study Start Date: April 2007
Study Completion Date: December 2009
Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)
Intervention Details:
    Dietary Supplement: Low carbohydrate
    43% CHO

Ages Eligible for Study:   21 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

Overweight, age 21-50 years,Women must be premenopausal, Normal glucose tolerance, weight stable for at least 6 months with a weight change no greater than 5 lbs.

Exclusion Criteria:

Exclusion criteria were type 1 or type 2 diabetes, polycystic ovarian disease, BMI <26.5 or weight >300 pounds, weight change >5 pounds in last 6 months, regular exercise >2 hours per week, pregnancy, currently breastfeeding, cholesterol medications, any disorders of glucose or lipid metabolism, use of medication that could affect body composition or glucose metabolism (including oral contraceptives and blood pressure medications), current use of tobacco, use of illegal drugs in last 6 months, history of hypoglycemic episodes, major food allergies or food dislikes, women with inconsistent or absence of monthly menstrual cycles, and a medical history that counter-indicated inclusion in the study.

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Please refer to this study by its identifier: NCT00726908

United States, Alabama
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294
Sponsors and Collaborators
University of Alabama at Birmingham
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Principal Investigator: Barbara A Gower, PhD Univ. Alabama Birmingham
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Barbara Gower, Professor, University of Alabama at Birmingham Identifier: NCT00726908     History of Changes
Other Study ID Numbers: F070322005
R01DK067538 ( US NIH Grant/Contract Award Number )
Study First Received: July 29, 2008
Last Updated: June 14, 2012

Keywords provided by University of Alabama at Birmingham:

Additional relevant MeSH terms:
Hypoglycemic Agents
Physiological Effects of Drugs processed this record on April 28, 2017