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Intramuscular Lipid and Insulin Action:Ethnic Aspects (QuEST)

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ClinicalTrials.gov Identifier: NCT00726908
Recruitment Status : Completed
First Posted : August 1, 2008
Last Update Posted : June 15, 2012
Sponsor:
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Information provided by (Responsible Party):
Barbara Gower, University of Alabama at Birmingham

Brief Summary:
High levels of the hormone insulin are associated with risk for heart disease and diabetes, and may make it hard to lose weight. The types of food eaten may affect insulin levels. The purpose of this study is to determine if manipulation of dietary carbohydrate content improves insulin sensitivity (Si), augments weight loss, and promotes weight loss maintenance in healthy adults.

Condition or disease Intervention/treatment
Obesity Dietary Supplement: Low carbohydrate

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 69 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
Official Title: Intramuscular Lipid and Insulin Action:Ethnic Aspects
Study Start Date : April 2007
Primary Completion Date : December 2009
Study Completion Date : December 2009

Resource links provided by the National Library of Medicine

Drug Information available for: Insulin
U.S. FDA Resources


Intervention Details:
    Dietary Supplement: Low carbohydrate
    43% CHO


Primary Outcome Measures :
  1. Insulin sensitivity [ Time Frame: IVGTT and minimal model ]

Secondary Outcome Measures :
  1. Weight loss [ Time Frame: Weight loss over 8 weeks ]


Information from the National Library of Medicine

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Ages Eligible for Study:   21 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

Overweight, age 21-50 years,Women must be premenopausal, Normal glucose tolerance, weight stable for at least 6 months with a weight change no greater than 5 lbs.

Exclusion Criteria:

Exclusion criteria were type 1 or type 2 diabetes, polycystic ovarian disease, BMI <26.5 or weight >300 pounds, weight change >5 pounds in last 6 months, regular exercise >2 hours per week, pregnancy, currently breastfeeding, cholesterol medications, any disorders of glucose or lipid metabolism, use of medication that could affect body composition or glucose metabolism (including oral contraceptives and blood pressure medications), current use of tobacco, use of illegal drugs in last 6 months, history of hypoglycemic episodes, major food allergies or food dislikes, women with inconsistent or absence of monthly menstrual cycles, and a medical history that counter-indicated inclusion in the study.


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00726908


Locations
United States, Alabama
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294
Sponsors and Collaborators
University of Alabama at Birmingham
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Investigators
Principal Investigator: Barbara A Gower, PhD Univ. Alabama Birmingham

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Barbara Gower, Professor, University of Alabama at Birmingham
ClinicalTrials.gov Identifier: NCT00726908     History of Changes
Other Study ID Numbers: F070322005
R01DK067538 ( U.S. NIH Grant/Contract )
First Posted: August 1, 2008    Key Record Dates
Last Update Posted: June 15, 2012
Last Verified: June 2012

Keywords provided by Barbara Gower, University of Alabama at Birmingham:
Obesity
diet
carbohydrate
insulin

Additional relevant MeSH terms:
Insulin
Hypoglycemic Agents
Physiological Effects of Drugs