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Genetic Polymorphisms of Interleukin-1B and TNF-A and HBV-Related Hepatocellular Carcinoma

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00629486
First Posted: March 6, 2008
Last Update Posted: April 18, 2013
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Jung-Fa,Tsai, Kaohsiung Medical University Chung-Ho Memorial Hospital
  Purpose
By detecting polymorphisms of IL-1β and TNF-α,this study aims to find the effects of cytokine gene polymorphisms(and their interaction) on susceptibility and severity of HBV-related HCC.

Condition Intervention
Hepatitis B Hepatocellular Carcinoma Chronic Liver Disease Genetic: Polymorphism of IL-1 beta and TNF-alpha

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Genetic Polymorphisms of Interleukin-1B and TNF-A and HBV-Related Hepatocellular Carcinoma

Further study details as provided by Jung-Fa,Tsai, Kaohsiung Medical University Chung-Ho Memorial Hospital:

Primary Outcome Measures:
  • cytokine polymorphisms increase risk for hepatocellular carcinoma [ Time Frame: years ]

Enrollment: 300
Study Start Date: January 2007
Study Completion Date: May 2008
Primary Completion Date: May 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: cytokines were determined
prevalence of genetic polymorphisms of interleukin 1B was measured in HBV-related hepatocellular carcinoma
Genetic: Polymorphism of IL-1 beta and TNF-alpha
To analyze the role of polymorphisms of IL-1beta and TNF-alpha gene on risk of hepatitis B-related chronic liver disease and hepatocellular carcinoma
Other Names:
  • polymorphism
  • TNF-alpha
  • interleukin-1L

Detailed Description:

Hepatitis B virus (HBV)infection is the major risk factor for chronic liver disease and hepatocellular carcinoma (HCC). Host immunogenetic factors contribute to HBV-associated liver damage and/or carcinogenesis. Variant cytokine alleles, including tumor necrosis factor-α(TNF-α)and interleukin-1β(IL-1β), might contribute to interindividual difference in inflammatory responses and account for heterogeneous disease outcome of infectious disease.

By detecting polymorphisms of IL-1β and TNF-α,this study aims to find the effects of cytokine gene polymorphisms(and their interaction) on susceptibility and severity of HBV-related HCC.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • HBsAg-positive patients

Exclusion Criteria:

  • HBsAg-negative patients
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00629486


Locations
Taiwan
Kaohsiung Medical University Chung-Ho Hospital
Kaohsiung, Taiwan, 807
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung, Taiwan, 807
Sponsors and Collaborators
Kaohsiung Medical University Chung-Ho Memorial Hospital
Investigators
Principal Investigator: Jung-Fa Tsai, M.D., Ph.D. Professor of Medicine
  More Information

Responsible Party: Jung-Fa,Tsai, Professor of Medicine, Kaohsiung Medical University Chung-Ho Memorial Hospital
ClinicalTrials.gov Identifier: NCT00629486     History of Changes
Other Study ID Numbers: KMUH-IRB-950181
First Submitted: February 26, 2008
First Posted: March 6, 2008
Last Update Posted: April 18, 2013
Last Verified: April 2013

Keywords provided by Jung-Fa,Tsai, Kaohsiung Medical University Chung-Ho Memorial Hospital:
cytokine gene
hepatitis B
hepatocellular carcinoma
chronic liver disease

Additional relevant MeSH terms:
Carcinoma
Hepatitis
Carcinoma, Hepatocellular
Hepatitis B
Liver Diseases
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms
Digestive System Diseases
Adenocarcinoma
Liver Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Hepadnaviridae Infections
DNA Virus Infections
Virus Diseases
Hepatitis, Viral, Human