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Day of Embryo Transfer for Patients Undergoing In Vitro Fertilization

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ClinicalTrials.gov Identifier: NCT00615771
Recruitment Status : Completed
First Posted : February 14, 2008
Last Update Posted : November 28, 2016
Sponsor:
Information provided by (Responsible Party):
Ruth Bunker Lathi, Stanford University

Brief Summary:
We are examining whether pregnancy rates differ based on day of embryo transfer in patients who replace all available embryos after an In vitro Fertilization (IVF) cycle. Patients must be undergoing IVF treatment at Stanford University and patients will not receive compensation for their participation (no medical costs covered or patient payment for participation).

Condition or disease Intervention/treatment Phase
Infertility Procedure: Day 3 embryo transfer Procedure: Day 2 embryo transfer Not Applicable

Detailed Description:
The decision on the number of embryos to transfer after an IVF cycle is based on the number of available embryos, the quality of the embryos, the patient's age, and the goal of limiting multiple gestations. Stanford Fertility Center and most IVF centers examine the embryos on the third day after oocyte (egg) retrieval to select for the best quality embryos to transfer, and depending on quality, the remaining embryos are frozen to be used in the future. Patients with a limited number of embryos, those that plan to replace all available embryos after an IVF cycle, do not need to wait until the third day after oocyte retrieval to select embryos, and may replace the embryos on the second day after the oocyte retrieval. We are examining whether pregnancy rates differ among these patients based on the day of embryo transfer (Day 2 vs. Day3). Patients must be undergoing IVF treatment at Stanford University and patients will not receive compensation for their participation (no medical costs covered or patient payment for participation).

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 242 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Embryo Transfer on Day 2 vs. Day 3 After Oocyte Retrieval in Patients Who Plan to Replace All Embryos After an In Vitro Fertilization Cycle
Study Start Date : January 2007
Actual Primary Completion Date : March 2009
Actual Study Completion Date : March 2009

Arm Intervention/treatment
Experimental: Day 2 embryo transfer
Embryos are transferred 2 days after fertilization.
Procedure: Day 2 embryo transfer
Embryos are transferred 1 day prior to standard of care

Active Comparator: Day 3 embryo transfer
Standard of care for women undergoing IVF with a limited number of embryos is to transfer all embryos on Day 3 after fertilization
Procedure: Day 3 embryo transfer
Standard of care




Primary Outcome Measures :
  1. Pregnancy rates [ Time Frame: 1 year ]

Secondary Outcome Measures :
  1. Live birth rates [ Time Frame: 1 year ]
  2. Multiple gestation rates [ Time Frame: 1 year ]


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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

Patients undergoing fresh IVF cycle at Stanford Fertility Center who plan on replacing all available embryos.

Exclusion Criteria:

Patients that do not meet above criteria.


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00615771


Locations
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United States, California
Stanford University School of Medicine
Stanford, California, United States, 94305
Sponsors and Collaborators
Stanford University
Investigators
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Principal Investigator: Lora K Shahine Stanford University

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Responsible Party: Ruth Bunker Lathi, associate professor, Stanford University
ClinicalTrials.gov Identifier: NCT00615771     History of Changes
Other Study ID Numbers: SU-01312008-991
First Posted: February 14, 2008    Key Record Dates
Last Update Posted: November 28, 2016
Last Verified: July 2011

Additional relevant MeSH terms:
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Infertility
Genital Diseases, Male
Genital Diseases, Female