Study of the Safety, Efficacy and Cycle Control of a Contraceptive Vaginal Ring
![]() |
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT00455156 |
Recruitment Status :
Completed
First Posted : April 3, 2007
Last Update Posted : August 10, 2018
|
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Contraception | Drug: 150 mg of Nestorone and 15 mg of ethinyl estradiol (150/15 NES/EE CVR) | Phase 3 |

Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 1143 participants |
Allocation: | N/A |
Intervention Model: | Single Group Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Prevention |
Official Title: | A Multicenter, Open-label Study on the Efficacy, Cycle Control and Safety of a Contraceptive Vaginal Ring Delivering a Daily Dose of 150µg of Nestorone® and 15µg of Ethinyl Estradiol (150/15 NES/EE CVR) |
Study Start Date : | December 2006 |
Actual Primary Completion Date : | January 2009 |
Actual Study Completion Date : | September 2011 |

Arm | Intervention/treatment |
---|---|
Experimental: 150/15 NES/EE CVR
150 mg of Nestorone and 15 mg of ethinyl estradiol (150/15 NES/EE CVR), administered via vaginal ring, used on a 21/7 days in/out schedule for no more than one year.
|
Drug: 150 mg of Nestorone and 15 mg of ethinyl estradiol (150/15 NES/EE CVR)
150 mg of Nestorone and 15 mg of ethinyl estradiol (150/15 NES/EE CVR), administered via vaginal ring, used on a 21/7 days in/out schedule for no more than one year. |
- To evaluate one-year data on the contraceptive efficacy and safety of the 150/15 NES/EE CVR as the basis for regulatory approvals of this CVR as a new delivery system for contraception. [ Time Frame: 12 Months ]
- To evaluate the cycle control, bleeding patterns and side effects [ Time Frame: 12 Months ]

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 18 Years to 39 Years (Adult) |
Sexes Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Healthy women, aged 18-<40 years who wish to use a combined hormonal contraceptive.
- Women not intending to become pregnant for 13 months.
- Intact uterus and both ovaries.
- Prior history of regular menstrual cycles of 28 ± 7 days when not using hormonal contraception; if postpartum or postabortal, history of regular menstrual cycles of 21-35 days in length and at least one cycle (2 menses) with a cycle length consistent with her past cycles.
- Sexually active (currently) and willing to discontinue current contraceptive method to participate in the study.
- In the opinion of the investigator, able to comply with the protocol, e.g. live within the study site catchment area or within a reasonable distance from the site.
- Do not meet any of the exclusion criteria.
- Signed informed consent prior to entry into the trial.
Exclusion Criteria:
- Known hypersensitivity to estrogens or progestins.
- Known hypersensitivity to silicone rubber.
- Known or suspected pregnancy.
- History of infertility of >1.0 year in woman or her male partner.
- History of vasectomy or sterility in male partner; tubal ligation (sterilization) in women
- Undiagnosed abnormal genital bleeding.
- Undiagnosed vaginal discharge or vaginal lesions or abnormalities. (Subjects diagnosed at screening with Chlamydia or gonorrhea may be included in the trial following treatment; partner treatment is also recommended. Investigators should make a determination if subjects are at high risk for reinfection, e.g. multiple sex partners, untreated partner, and whether such subjects can be included.)
- History of pelvic inflammatory disease since last pregnancy episode.
- History of toxic shock syndrome.
- Current abnormal Pap smear (women who have abnormal Paps but are ASCUS HPV negative may participate provided there is follow up for this finding per standard of care).
- Cystoceles or rectoceles or other anatomical abnormality that would preclude use of a vaginal ring.
- Women planning to undergo major surgery.
- Smoking in women who are 35 years and over or will be 35 years during the course of the trial; Women < 35 years who smoke 15 cigarettes or more must be evaluated by the PI for inclusion based on risk factors that would increase their risk for CVD, e.g. lipid levels, glucose level, BP, BMI, family history of CVD at a young age.
- Breastfeeding.
- Current or past thrombophlebitis or thromboembolic disorders.
- History of venous thrombosis or embolism in a first-degree relative <55 years of age suggesting familial defect in blood coagulation system, which in the opinion of the principal investigator, suggests use of a hormonal contraceptive could pose a significant risk.
- Cerebrovascular or cardiovascular disease.
- History of retinal vascular lesions, unexplained partial or complete loss of vision.
- Known or suspected carcinoma of the breast.
- Carcinoma of the endometrium or other known or suspected estrogen-dependent neoplasia.
- Past history of any other carcinoma unless in remission for more than 5 years.
- Current or past medically diagnosed severe depression, which, in the opinion of the investigator, could be exacerbated by use of a hormonal contraceptive.
- Headaches with focal neurological symptoms.
- Severe constipation.
- History of cholestatic jaundice of pregnancy or jaundice with prior steroid use.
- Benign or malignant liver tumors; active liver disease.
- Diastolic blood pressure (BP) ³85 mm Hg and/or systolic BP ³135 mm Hg after 5-10 minutes rest.
- Known or suspected alcoholism or drug abuse.
- Abnormal serum chemistry values according to the physician's judgment.
- Participation in another clinical trial within last 30 days.
- Weight >95 kg or >209 lbs.
- Use of liver enzyme inducers on a regular basis.
- Use of monthly injectable contraceptives (e.g. cyclofem) unless suspended 2 months before initiation of treatment. Use of Depo-Proveraâ [depo-medroxyprogesterone (DMPA)] unless suspended 6 months before treatment.
- Current use of implanted hormonal contraceptives, including Mirenaâ [progestin containing intrauterine system (IUS)], Jadelleâ, Norplantâ or Implanonâ (subjects using any of these methods who request removal for reasons unrelated to the purpose of enrollment in this study may be considered for participation).
- Current use of a non-hormonal IUD. Subjects with IUDs who request removal for reasons unrelated to the purpose of enrollment in this study may be considered for participation.
- Known HIV infection.
- Women at high risk of contracting HIV, e.g. women with multiple sex partners who need to use condoms consistently, injection drug users. If women enrolled in the study do use condoms to protect against STIs, they should be instructed that this occasional use should be with non-N-9 containing condoms and they should record condom use in their diaries. Women found to have an STI at screening will be treated prior to inclusion in the study (with the exception of those infected with HIV).

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00455156
United States, California | |
California Family Health Council | |
Los Angeles, California, United States, 90010 | |
United States, Colorado | |
University of Colorado - Adv. Repro. Med. | |
Denver, Colorado, United States, 80010 | |
United States, Kentucky | |
University of Kentucky | |
Lexington, Kentucky, United States, 40536-0293 | |
United States, Maryland | |
Contraceptive Research and Programs | |
Baltimore, Maryland, United States, 21224 | |
United States, Massachusetts | |
Baystate Medical Center | |
Springfield, Massachusetts, United States, 01199 | |
United States, New York | |
NYU Medical Center Family Planning Division | |
New York, New York, United States, 10016 | |
Columbia University | |
New York, New York, United States, 10032 | |
United States, Ohio | |
University of Cincinnati College of Medicine | |
Cincinnati, Ohio, United States, 45267 | |
MacDonald Physicians, Inc. | |
Cleveland, Ohio, United States, 44124 | |
The Ohio State University | |
Columbus, Ohio, United States, 43210 | |
United States, Oregon | |
Oregon Health Sciences University | |
Portland, Oregon, United States, 97201 | |
United States, Pennsylvania | |
University of Pennsylvania Medical Center | |
Philadelphia, Pennsylvania, United States, 19104 | |
Magee-Womens Hospital | |
Pittsburgh, Pennsylvania, United States, 15213 | |
United States, Texas | |
UT Southwestern Medical Center; Division of Community Women's Health Care | |
Dallas, Texas, United States, 75235 | |
United States, Virginia | |
Jones Institute of Repro Medicine, EVMS | |
Norfolk, Virginia, United States, 23507 |
Study Director: | Diana L. Blithe, PH.D. | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) |
Responsible Party: | Health Decisions |
ClinicalTrials.gov Identifier: | NCT00455156 |
Other Study ID Numbers: |
CCN006 CCN006 ( Other Identifier: NICHD ) |
First Posted: | April 3, 2007 Key Record Dates |
Last Update Posted: | August 10, 2018 |
Last Verified: | August 2018 |
Contraception Vaginal Ring |
Ethinyl Estradiol ST 1435 Estradiol Estrogens Hormones Hormones, Hormone Substitutes, and Hormone Antagonists Physiological Effects of Drugs |
Contraceptive Agents, Hormonal Contraceptive Agents Reproductive Control Agents Contraceptive Agents, Female Contraceptives, Oral, Hormonal Contraceptives, Oral |