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Neuromuscular and Cognitive Fatigue During a 24 Hour Treadmill Running Exercise

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00428779
First Posted: January 30, 2007
Last Update Posted: June 11, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Centre Hospitalier Universitaire de Saint Etienne
  Purpose
The main purpose of the present study is to determine the relative contributions of central and peripheral fatigue during an ultra-endurance exercise.

Condition Intervention
Healthy Procedure: running during 24 hours without sleep Other: no sleeping

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Health Services Research
Official Title: Neuromuscular and Cognitive Fatigue During a 24h Treadmill Running Exercise.

Resource links provided by NLM:


Further study details as provided by Centre Hospitalier Universitaire de Saint Etienne:

Primary Outcome Measures:
  • -Voluntary and electrically evoked forces on the contracted muscles [ Time Frame: 24 hours ]

Secondary Outcome Measures:
  • Electrically evoked forces on the relaxed muscles and associated EMG activity [ Time Frame: 24 hours ]
  • Blood samples before the exercise [ Time Frame: every 4 hours ]
  • Muscle biopsy (vastus lateralis) [ Time Frame: before and after the exercise ]

Enrollment: 30
Study Start Date: September 2007
Study Completion Date: December 2007
Primary Completion Date: December 2007 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
patients running during 24 hours without sleep
Procedure: running during 24 hours without sleep
patients running during 24 hours without sleep
Placebo Comparator: 2
patients without sleep during 24 hours
Other: no sleeping
patients without sleep during 24 hours

Detailed Description:
For that purpose, 14 subjects running 24 hours on a treadmill will be compared with a control group being awake during the same period. Subjects who running will have electrically evoked forces on the muscles associated EMG activity, blood samples and muscle biopsy.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • The subjects of the experimental group will be recruited among experienced ultra-runners . They all have run at least a 12 hour race or longer.
  • The control group will be recruited among experienced ultra-runners . Age of control group will be age experimental group more or less 2 years.

Exclusion Criteria:

  • The subjects will not be selected if:

    • they were injured in the 3 months before the experiment
    • they had a tendon or joint pathology that could impair strength measurements.
    • they participate to an other experiment at the same time
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00428779


Locations
France
Pr André GEYSSANT
Saint-etienne, France, 42055
Sponsors and Collaborators
Centre Hospitalier Universitaire de Saint Etienne
Investigators
Study Chair: DENIS Christian, Professor Service de médecine du sport, CHU SAINT-ETIENNE
  More Information

Publications:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Clément CAILLAUX, CHU de Saint-Etienne
ClinicalTrials.gov Identifier: NCT00428779     History of Changes
Other Study ID Numbers: 0601095
DGS 2006-0111
2006-A00312-49
First Submitted: January 29, 2007
First Posted: January 30, 2007
Last Update Posted: June 11, 2009
Last Verified: June 2009

Keywords provided by Centre Hospitalier Universitaire de Saint Etienne:
Running during 24 hours
Voluntary evoked force on the muscles
Electrically evoked force on the muscles
EMG activity
Muscle biopsy
subjects will be recruited among experienced ultra-runners

Additional relevant MeSH terms:
Fatigue
Signs and Symptoms