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Chromogranin-A-Derived Peptides and Periodontitis in Diabetic Patients

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified January 2009 by University Hospital, Strasbourg, France.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00399620
First Posted: November 15, 2006
Last Update Posted: January 12, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
University Hospital, Strasbourg, France
  Purpose
Periodontitis is a chronic disease of the supporting tissue of the teeth, characterized by bleeding and inflamed gingival, resorption of alveolar bone. This disease has a significant impact of the quality of life as the teeth become progressively mobile and may fall out spontaneously if no treatment is provided. Periodontal disease has been cited as the sixth complication of diabetes mellitus.Chromogranins / secretogranins are a family of proteins present in nervous endocrine and immune cells, released with catecholamines during stress situations. Chromogranin A (CGA) is the major member of this family.The aim of this study is to determine the level of CGA and its derived peptides in the gingival crevicular fluid (GCF) of health or diabetic patients with and without periodontitis.Then, we want to determine the antimicrobial activity of these peptides.

Condition Intervention
Periodontitis and Diabetitis Procedure: Gingival crevicular fluid samples (this procedure is added to the subject usual medical follow-up).

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: Chromogranin-A-Derived Peptides in the Gingival Crevicular Fluid and the Saliva of Diabetic Patients With or Without Periodontitis

Further study details as provided by University Hospital, Strasbourg, France:

Estimated Enrollment: 90
Study Start Date: March 2008
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion criteria:

  • Patients from 20 to 80 years old
  • A minimum of 10 teeth
  • Healthy volunteers or diabetic patients with or without periodontitis

Exclusion criteria:

  • a course of antibiotics
  • a fungicidal therapy
  • a corticotherapy
  • a hormone therapy
  • a pregnancy
  • persons under guardianship
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00399620


Contacts
Contact: Martine Soell, MD 33 6 74 86 67 36 martine.soell@chru-strasbourg.fr

Locations
France
Département de Parodontologie - Hôpital Civil Recruiting
Strasbourg, France, 67091
Contact: Martine Soell, MD    33.6.74.86.67.36    martine.soell@chru-strasbourg.fr   
Principal Investigator: Martine Soell, MD         
Sub-Investigator: Frédéric Blickle, MD         
Sponsors and Collaborators
University Hospital, Strasbourg, France
Investigators
Study Director: Martine Soell, MD Hôpitaux Universitaires de Strasbourg
  More Information

ClinicalTrials.gov Identifier: NCT00399620     History of Changes
Other Study ID Numbers: 3739
First Submitted: November 14, 2006
First Posted: November 15, 2006
Last Update Posted: January 12, 2009
Last Verified: January 2009

Keywords provided by University Hospital, Strasbourg, France:
Periodontitis
Diabetes
Gingival crevicular fluid
GCF
Saliva
Chromogranin
Electrophorèse
Western Blot
RT-HPLC

Additional relevant MeSH terms:
Periodontitis
Periodontal Diseases
Mouth Diseases
Stomatognathic Diseases