A Randomized, Double-Blind, Placebo-Controlled Trial of Simvastatin on Subarachnoid Hemorrhage-Induced Vasospasm
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Aneurysmal subarachnoid hemorrhage, Fisher Grade III.
Patient or spouse or first degree relative able to give informed consent
Age greater then 18
Aneurysm secured surgically, or via endovascular technique
Subject seen within 96 hours of bleeding
Contraindication for the use of simvastatin
Hunt-Hess Grade V
Initial intracranial pressure over 30 cm H2O and sustained for more then 30 minutes
Patient already on an HMG CoA-reductase inhibitor.
Patients with severe chronic renal failure (creatinine >3 and/or BUN >40).