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Nefazodone in the Treatment of Social Phobia

This study has been completed.
Bristol-Myers Squibb
Information provided by (Responsible Party):
Emory University Identifier:
First received: October 3, 2005
Last updated: November 8, 2013
Last verified: November 2013
The purpose of this study is to determine the effectiveness of nefazadone in patients with social anxiety disorder (SAD).

Condition Intervention Phase
Social Anxiety Disorder (SAD)
Drug: Nefazodone
Phase 4

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Nefazodone in the Treatment of Social Phobia: Functional Brain Imaging and Neuroendocrine Correlates

Resource links provided by NLM:

Further study details as provided by Emory University:

Estimated Enrollment: 24
Study Completion Date: April 2000
Detailed Description:
The purpose of this study is to examine the efficacy of the 5HT2 receptor antagonist nefazadone in SAD, and to explore regional cerebral blood flow in patients with SAD when confronted with a personal phobic stimulus, using positron emission tomography (PET). Changes in cerebral blood flow were correlated with self-rated anxiety measures.

Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • DSM-IV diagnosis of generalized social anxiety disorder, males and females between the ages of 18-65

Exclusion Criteria:

  • A history of bipolar disorder, psychotic illness, or any other anxiety disorders, organic brain disease or active drug or alcohol abuse within one year as assessed by the SCID-P and interview, or a concurrent medical condition that would not be compatible with the study in the opinion of the principal investigator. Patients required to be free of psychotropic or beta-blocker medication for 2 weeks prior to study. Pts taking fluoxetine required to be drug-free for 6 weeks.
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Please refer to this study by its identifier: NCT00231348

United States, Georgia
Emory University Depatment of Psychiatry and Behavioral Sciences
Atlanta, Georgia, United States, 30322
Sponsors and Collaborators
Emory University
Bristol-Myers Squibb
Principal Investigator: Charles B Nemeroff, MD, PhD Emory University Department of Psychiatry and Behavioral Sciences
Study Director: Clinton D Kilts, PhD Emory University Department of Psychiatry and Behavioral Sciences
Study Director: Jeffrey Newport, MD Emory University Department of Psychiatry and Behavioral Sciences
  More Information

Responsible Party: Emory University Identifier: NCT00231348     History of Changes
Other Study ID Numbers: 0707-1997
Study First Received: October 3, 2005
Last Updated: November 8, 2013

Keywords provided by Emory University:
Social anxiety disorder
social phobia
positron emission tomography (PET
regional cerebral blood flow (rCBF)

Additional relevant MeSH terms:
Anxiety Disorders
Phobic Disorders
Mental Disorders
Antidepressive Agents, Second-Generation
Antidepressive Agents
Psychotropic Drugs processed this record on May 25, 2017