The Effect of North American Ginseng on Blood Pressure in Individuals With Hypertension
To determine the effect of North American ginseng on blood pressure in individuals with hypertension.
Drug: North American Ginseng (Panax Quinquefolius)
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Primary Purpose: Treatment
|Official Title:||The Effect of North American Ginseng on Blood Pressure in Individuals With Hypertension|
- Mean 24 Hour Ambulatory Blood Pressure
- Mean Daytime Ambulatory Blood Pressure
- Mean Nighttime Ambulatory Blood Pressure
- Cystatin C
|Study Start Date:||April 2001|
|Estimated Study Completion Date:||October 2003|
Ginseng lacks proper clinical scrutiny for its effect on blood pressure (BP), in spite of observational evidence linking its intake to hypertension. This should be addressed considering the potential overlap between the prevalence of ginseng use and hypertension.
We undertook a single centre, randomized, controlled, double-blinded, crossover trial to determine the effect of North American ginseng (NAG) on 24-hour BP and renal function. After a 4-week placebo run-in, we randomly assigned participants to NAG or placebo treatment for 12-weeks at a dose of 3g/day. This was followed by an 8-week washout, and a subsequent 12-week period in which the opposite treatment was consumed. At run-in, and at weeks 0 and 12 of each treatment period, participants were fitted with an ambulatory BP monitor to assess 24-hour BP and serum cystatin C was measured.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00219960
|Risk Factor Modification Centre, St. Michael's Hospital|
|Toronto, Ontario, Canada, M5C 2T2|
|Principal Investigator:||Vladimir Vuksan, PhD||Risk Factor Modification Centre, St. Michael's Hospital|