TACT-NAGOYA: Therapeutic Angiogenesis Using Cell Transplantation
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ClinicalTrials.gov Identifier: NCT00145262
Recruitment Status : Unknown
Verified August 2003 by Nagoya University. Recruitment status was: Recruiting
Clinical studies have established that implantation of bone marrow mononuclear cells (BM-MNCs) or peripheral blood mononuclear cells (PB-MNCs) into ischaemic limbs increases collateral vessel formation. We, the investigators at Nagoya University, further investigated the efficacy and safety of autologous implantation of BM-MNCs or PB-MNCs in patients with severe ischaemic limbs who have no other alternative therapeutic options. We also examined a potential limiting factor which reduced the efficacy of therapeutic angiogenesis using cell transplantation (TACT).
Condition or disease
Buerger DiseaseArteriosclerosis Obliterans
Procedure: Autologous Bone Marrow Mononuclear Cell Implantation
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Layout table for eligibility information
Ages Eligible for Study:
20 Years to 80 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Subjects who have chronic limb ischemia, including rest pain, non-healing ischemic ulcers, or both, and who are not candidates for nonsurgical or surgical revascularisation.