Assessing the Occupation Burden in COPD

This study has been completed.
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI) Identifier:
First received: November 20, 2000
Last updated: January 20, 2006
Last verified: January 2006

To assess the population burden of occupational exposures in the prevalence and progression of chronic obstructive pulmonary disease (COPD).

Lung Diseases, Obstructive
Chronic Obstructive Pulmonary Disease

Study Type: Observational
Study Design: Observational Model: Natural History

Resource links provided by NLM:

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date: September 2000
Estimated Study Completion Date: August 2004
Detailed Description:


Chronic obstructive pulmonary disease is the only one of the top four or five leading causes of death in the U.S. with worsening epidemiological trends. Cigarette smoking accounts for approximately 85 percent-90 percent of cases, but the other 10 percent-15 percent of the attributable risk still represents a substantial fraction of this disease that remains unexplained. Recently, several studies, in various countries, have addressed whether certain occupational exposures (primarily those relating to dusts, vapors, gases, and/or fumes) are potential risk factors for COPD. Most of these studies have shown elevated odds ratios or relative risks, although not always to a statistically significant level.


A population sample of the continental United States of those aged 55-75, supplemented by an enriched sample in geographic "hot spots" identified by the National Institute for Occupational Safety and Health (NIOSH) through respiratory diseases mapping. Structured telephone interviews assessed demographics, health status, smoking exposures, and occupational histories. High risk jobs were coded using a job matrix system independent of subject report of specific exposures. Two hundred thirty-four of those with COPD, with over-sampling of those with greater severity, were followed at 12-14 months to assess health status and health services utilization, as well as decrements in quality of life.


Ages Eligible for Study:   55 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

No eligibility criteria

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Please refer to this study by its identifier: NCT00006513

Sponsors and Collaborators
Investigator: Paul Blanc University of California, San Francisco
  More Information

Publications: Identifier: NCT00006513     History of Changes
Other Study ID Numbers: 949
Study First Received: November 20, 2000
Last Updated: January 20, 2006
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Lung Diseases
Respiratory Tract Diseases processed this record on March 26, 2015