Diagnostic Study of Adrenal Cortical Function in Children With Septic Shock
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|ClinicalTrials.gov Identifier: NCT00005890|
Recruitment Status : Completed
First Posted : June 5, 2000
Last Update Posted : June 24, 2005
I. Examine adrenal cortical function and the incidence of adrenal dysfunction in children with septic shock.
II. Examine the mortality, length of stay in the PICU, and incidence of multiorgan failure in children with adrenal dysfunction and septic shock.
|Condition or disease||Intervention/treatment||Phase|
|Septic Shock||Drug: corticotropin||Not Applicable|
Patients undergo a corticotropin stimulation test within 8 hours of admission to the PICU. Blood samples for plasma cortisol and corticotropin levels are drawn at time 0 followed by corticotropin 1-24 IV. Additional cortisol levels are drawn at 30 and 60 minutes. Corticotropin is measured by immunoradiometric assay and cortisol is measured by radioimmunoassay. Mean arterial blood pressure, heart rate, and respiratory rate are recorded at baseline and at 60 minutes.
Patients receive routine management for septic shock and multiple organ system failure.
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||56 participants|
|Study Start Date :||March 1996|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00005890
|United States, Ohio|
|Children's Hospital Medical Center - Cincinnati|
|Cincinnati, Ohio, United States, 45229-3039|
|Study Chair:||Richard J. Brilli||Children's Hospital Medical Center, Cincinnati|