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Parity and Serum Lipids in White and Hispanic Women

This study has been completed.
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by (Responsible Party):
University of Pennsylvania Identifier:
First received: May 25, 2000
Last updated: January 19, 2016
Last verified: January 2016
To analyze the relationships between parity (childbirth) or gravidity (pregnancy) and measures of lipids in groups of women from the Hispanic Health and Nutrition Examination Survey (Hispanic HANES) and the Framingham Heart Study.

Cardiovascular Diseases
Heart Diseases

Study Type: Observational

Further study details as provided by University of Pennsylvania:

Study Start Date: September 1991
Study Completion Date: September 1993
Primary Completion Date: September 1993 (Final data collection date for primary outcome measure)
Detailed Description:


The relationships between parity or gravidity and measures of lipids in groups of women from the Hispanic Health and Nutrition Examination Survey (Hispanic HANES) and the Framingham Heart Study offered insights into the health of an important minority group in the United States and provided clues regarding hormonal mechanisms in lipoprotein metabolism.


In the Framingham cohort, the relationships among gravidity, LDL-cholesterol, HDL-cholesterol and total cholesterol were prospectively studied. Each of these serum lipids was tested as a potential mediator of associations between gravidity and various cardiovascular endpoints. In the Hispanic HANES, the associations among parity, gravidity, and lipid levels were examined in cross-sectional data on women of a different ethnic background in whom birth rates tended to be high. Secondary analysis of these two datasets was conducted, carefully considering aspects of the study designs. Bivariate analyses generated mean lipid levels within parity or gravidity groups. HDL, LDL, and total cholesterol were then stratified both by parity and other variables (such as age and smoking status) so that interactions could be considered. Multivariate analyses were used to analyze the effect of parity on lipids and cardiovascular disease events while controlling for a variety of potentially confounding factors (such as body mass index, subscapular/triceps, skinfold ratio, education, income, cigarette smoking, alcohol consumption, oral contraceptive use, estrogen replacement therapy, menopausal status and type of menopause). Interactions were also considered in multivariate models.


Ages Eligible for Study:   up to 100 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
No eligibility criteria
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  More Information

Responsible Party: University of Pennsylvania Identifier: NCT00005405     History of Changes
Other Study ID Numbers: 4322
R03HL046168 ( US NIH Grant/Contract Award Number )
Study First Received: May 25, 2000
Last Updated: January 19, 2016

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases
Arterial Occlusive Diseases
Vascular Diseases processed this record on May 25, 2017