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Evaluating Strategies to Control Hypercholesterolemia

This study has been completed.
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:
National Bureau of Economic Research, Inc. Identifier:
First received: May 25, 2000
Last updated: December 21, 2015
Last verified: December 2015
To determine the cost-effectiveness of alternative strategies for cholesterol reduction.

Cardiovascular Diseases Heart Diseases Hypercholesterolemia

Study Type: Observational

Resource links provided by NLM:

Further study details as provided by National Bureau of Economic Research, Inc.:

Study Start Date: April 1991
Estimated Study Completion Date: January 1993
Detailed Description:


The availability of effective treatment for hypercholesterolemia raised the hope that millions of Americans could avoid or postpone the development of heart disease. Because the interventions were potentially effective but were also costly, the cost-effectiveness of alternative approaches to detecting and treating hypercholesterolemia had become a critical issue for health policy.

The study was part of a three-grant initiative, Cost-Effective Strategies of Cholesterol-Lowering, which was recommended by the Arteriosclerosis, Hypertension, and Lipid Metabolism Advisory Committee in January, 1988 and given concept clearance at the September, 1988 National Heart, Lung, and Blood Advisory Council. The Request for Applications was released in March, 1990 and awards made in April, 1991.


Assessments were made of: effects of treatment on health outcomes (symptomatic coronary heart disease, death from coronary heart disease, and mortality from all causes); costs and effectiveness of specific dietary and pharmacological interventions; effects of delays in instituting treatment; effects of changing the interval between blood cholesterol tests on the probability and duration of treatment delay; cost and health consequences of modifying screening and treatment recommendations for other risk factors, age, and gender; population implications of screening and treatment strategies. Data from the Framingham Heart Study were used to estimate the time pattern of cholesterol levels, which was fundamental to the evaluation of changing the interval between cholesterol tests. Framingham data were also used to estimate the relation of event rates to blood cholesterol levels. Several components of the analysis were validated by testing model predictions against data from the Multiple Risk Factor Intervention Trial. The cost estimates were based on several additional sources. Individual-level cost-effectiveness estimates for several different interventions were presented along with population-level projections of the consequences of alternative strategies. The significance of altering assumptions about uncertain values, such as the long-term risks and benefits of specific medications, was tested in sensitivity analyses.


Ages Eligible for Study:   up to 100 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
No eligibility criteria
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  More Information

Publications: Identifier: NCT00005350     History of Changes
Other Study ID Numbers: 4219
R01HL046297 ( U.S. NIH Grant/Contract )
Study First Received: May 25, 2000
Last Updated: December 21, 2015

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases
Lipid Metabolism Disorders
Metabolic Diseases processed this record on September 18, 2017