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Effects of Simvastatin on Biomarkers (SimBio)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01142336
First Posted: June 11, 2010
Last Update Posted: July 28, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborators:
Seattle Institute for Biomedical and Clinical Research
VA Puget Sound Health Care System
Information provided by (Responsible Party):
Gail Li, University of Washington
  Purpose
A year-long randomized, double-blind, placebo-controlled trial of simvastatin to see if it produces beneficial changes in cerebral spinal fluid proteins associated with Alzheimer's disease.

Condition Intervention Phase
Alzheimer's Disease Drug: Simvastatin Drug: Placebo Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
Official Title: Effects of Simvastatin on CSF AD Biomarkers in Cognitively Normal Subjects

Resource links provided by NLM:


Further study details as provided by Gail Li, University of Washington:

Primary Outcome Measures:
  • Change From Baseline in Aβ42 in Cerebrospinal Fluid (CSF) at 1 Year [ Time Frame: 1-year change of CSF Aβ42 from baseline ]
    CSF Aβ42 concentration were measured at baseline and after 1-year intervention.

  • Change From Baseline in CSF Total Tau at 1 Year [ Time Frame: 1-yr change ]
    CSF total tau was measured at baseline and after 1-year of intervention

  • Change From Baseline in CSF ptau181 at 1 Year [ Time Frame: 1-year change from baseline ]
    ptau 181 measured in CSF at baseline and after 1-year intervention


Enrollment: 49
Study Start Date: June 2010
Study Completion Date: October 2015
Primary Completion Date: October 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Simvastatin
Simvastatin 40mg qHS for 1 year
Drug: Simvastatin
Simvastatin 40mg qHS for 1 year
Other Name: Zocor
Placebo Comparator: Placebo
Placebo 1 tablet qHS for 1 year
Drug: Placebo
Placebo 1 tablet qHS for 1 year
Other Name: Sugar Pill

Detailed Description:

The purpose of this study is to see if a drug called simvastatin (brand name Zocor) beneficially affects the level of certain molecules (such as proteins) in the spinal fluid of people. The molecules the investigators are measuring are thought to be important in the development of Alzheimer's disease (AD), and the investigators are testing whether simvastatin can change proteins to a level that is associated with a reduced risk for AD.

Simvastatin has been approved by the United States Food and Drug Administration (FDA) for the treatment of high cholesterol and to reduce the risk of coronary artery disease. It is an investigational drug in this study.

Participants will be randomly assigned to Placebo or Simvastatin. The investigators and the participant will be blinded. Randomization will be stratified by age and gender.

This study is being funded by the National Institute on Aging. The investigators will take part in this study at the VA Puget Sound Health Care System.

This study will last up to 1 year. Participants will be asked to come to the VA in Seattle a total of 9 times, 2 of those times will be for lumbar punctures (also known as a spinal tap).

The investigators would also like to ask a person who knows the participant well (such as a spouse, child, sibling, or good friend) some questions about the participant's health, memory, mood and behavior, and abilities to do daily tasks at the beginning and the end of the study.

Participants must be cognitively normal, healthy, willing to have a lumbar puncture, and not need or take any medications to control cholesterol.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   45 Years to 64 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria (participants must meet the following criteria)

  • If female of childbearing potential, must have negative pregnancy test at baseline, and all subsequent visits.
  • Age 45 to 64 years inclusive.
  • Considered cognitively normal with no evidence of memory or other cognitive impairments (MMSE >26, Logical Memory delayed recall > 6, CDR score of 0).
  • Normal or only mildly elevated cholesterol which does not require drug therapy based on National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATP-III) guidelines.
  • An LDL level above 70mg/dL.
  • Hamilton Depression Scale (HAM-D) score < 12.
  • BMI between 18 - 34 (or exception made by MD).
  • In good recent general health (i.e., no trauma or infection in the 4 weeks before LP).
  • On stable dose of non-exclusionary medications for the 4 weeks preceding the LP.
  • Platelet count >100,000.

Exclusion Criteria (participants must NOT satisfy any of the following conditions)

  • Any contraindications to LP, such as spinal deformity, severe disease or infection in the LP region, bleeding tendency, anticoagulant or blood-thinning medications.
  • Taken a statin medication in the past 12 months.
  • Any clinically significant laboratory abnormalities.
  • Any neurological disorders: multiple sclerosis, epilepsy, stroke, Parkinson's, other degenerative CNS disorders, or neuropathy with radicular involvement.
  • Acute or chronic major psychiatric disorders: schizophrenia, affective disorders, or severe anxiety disorders. (Dysthymia allowed, history of MDD allowed if currently in remission)
  • Unstable or poorly controlled medical problems such as: heart failure, diabetes (poorly controlled or insulin dependent), hypertension (BP >160/100), pulmonary disease with hypoxia or hypercapnia, significant liver disease or known hepatitis C seropositivity, renal failure, treatment for cancer in the past 2 years (other than non-melanoma skin cancer) or known HIV positive status.
  • Use of illegal drugs or alcohol abuse (>2 drinks/day or 10/week) within the past year.
  • Concurrent participation in another investigational drug study.
  • Use of any exclusionary medications in the 4 weeks prior to screening:

    • Drugs which could interact with statins: itraconazole, ketoconazole, erythromycin, clarithromycin, HIV protease inhibitors, nefazodone, amiodarone, cyclosporine, isoniazid, quinidine, or large quantities of grapefruit juice (>1 quart daily)
    • Central nervous system acting medications: antipsychotics, anti-Parkinson's disease medications, anti convulsants, or CNS stimulants
    • Chronic use of benzodiazepines, sedating antihistamines, or other sedative-hypnotic agents (prn use is allowed as long as it is not within 72 hours of LP or cognitive testing)
    • Medications affecting coagulation and/or inflammation: coumadin, potent anti-inflammatory medications (hydrocortisone, methotrexate or other potent immune-modulating medications), and anti-HIV medications (Aspirin up to 325 mg/day is allowed.)
    • Lipid-lowering drugs: fibrates or niacin >500mg/day (stable dose of omega-3 is allowed)
  • Does the subject's family history meet any of the following criteria?

    • Both parents had/have dementia
    • On one side of the family, over two consecutive generations three relatives had/have dementia?
    • One parent had an onset of dementia before age 60?
  • Does the subject have a major active autoimmune or immunological disorder?
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01142336


Locations
United States, Washington
VA Puget Sound Health Care System
Seattle, Washington, United States, 98108
Sponsors and Collaborators
University of Washington
Seattle Institute for Biomedical and Clinical Research
VA Puget Sound Health Care System
Investigators
Principal Investigator: Gail Li, MD, PhD University of Washington
  More Information

Responsible Party: Gail Li, Associate Professor, Psychiatry and Behavioral Sciences, University of Washington
ClinicalTrials.gov Identifier: NCT01142336     History of Changes
Other Study ID Numbers: 37373
00183 ( Other Identifier: VA Puget Sound Health System MIRB# )
First Submitted: June 9, 2010
First Posted: June 11, 2010
Results First Submitted: March 28, 2017
Results First Posted: July 28, 2017
Last Update Posted: July 28, 2017
Last Verified: June 2017

Studies a U.S. FDA-regulated Drug Product: Yes

Keywords provided by Gail Li, University of Washington:
Alzheimer's Disease
Prevention
Spinal Fluid
Biomarkers
Simvastatin

Additional relevant MeSH terms:
Alzheimer Disease
Dementia
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Tauopathies
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders
Simvastatin
Anticholesteremic Agents
Hypolipidemic Agents
Antimetabolites
Molecular Mechanisms of Pharmacological Action
Lipid Regulating Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Enzyme Inhibitors