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Nitrous Oxide for Analgesia During Colonoscopy

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00318825
Recruitment Status : Completed
First Posted : April 27, 2006
Last Update Posted : December 1, 2010
Information provided by:
Rikshospitalet University Hospital

Brief Summary:
The purpose of the study is to determine the analgetic effect of nitrous oxide during colonoscopy, compared to no sedation and intravenous (IV) sedation.

Condition or disease Intervention/treatment Phase
Pain Drug: Nitrous oxide Phase 4

  Show Detailed Description

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 200 participants
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double
Primary Purpose: Treatment
Official Title: Use of Nitrous Oxide for Analgesia During Colonoscopy - A Randomised Trial
Study Start Date : April 2006
Primary Completion Date : September 2008
Study Completion Date : September 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Colonoscopy
U.S. FDA Resources

Primary Outcome Measures :
  1. Does the use of nitrous oxide (N2O) during colonoscopy result in adequate analgesia for the patient?

Secondary Outcome Measures :
  1. Are there any side-effects due to the use of N2O during colonoscopy?
  2. Is there a reduction in the number of patients needing IV sedation?
  3. Is there any dose reduction of IV drugs?

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients referred for colonoscopy

Exclusion Criteria:

  • Patients who don't understand information given
  • Age under 18 years
  • Pregnancy
  • Otitis/sinusitis
  • Ileus/bowel obstruction
  • Megacolon
  • Suspected pneumothorax

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00318825

Rikshospitalet University Hospital
Oslo, Norway, 0027
Sponsors and Collaborators
Rikshospitalet University Hospital
Principal Investigator: Michael Bretthauer, MD, PhD Oslo University Hospital

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00318825     History of Changes
Other Study ID Numbers: s-05225
First Posted: April 27, 2006    Key Record Dates
Last Update Posted: December 1, 2010
Last Verified: April 2006

Keywords provided by Rikshospitalet University Hospital:

Additional relevant MeSH terms:
Nitrous Oxide
Anesthetics, Inhalation
Anesthetics, General
Central Nervous System Depressants
Physiological Effects of Drugs
Analgesics, Non-Narcotic
Sensory System Agents
Peripheral Nervous System Agents