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Marijuana Treatment Project - 3 (MTP-3)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00107588
Recruitment Status : Completed
First Posted : April 6, 2005
Last Update Posted : July 28, 2017
National Institute on Drug Abuse (NIDA)
Information provided by (Responsible Party):
Mark Litt, UConn Health

Brief Summary:
The goal of this research is to improve treatment outcome for marijuana-dependent individuals. The current study builds on the findings of our prior NIDA-funded marijuana treatment study in which improved client outcomes were associated with greater treatment attendance, greater client self-efficacy, and greater use of coping skills. We will use a contingency management paradigm to provide tangible reinforcement for completing homework assignments that are designed to enhance coping skills. It is anticipated that this will result in greater homework compliance, leading to greater self-efficacy regarding one's ability to cope with high-risk situations. Improved self-efficacy will enhance the likelihood of employing coping skills in high-risk situations, thereby increasing the probability of achieving and maintaining abstinence.

Condition or disease Intervention/treatment Phase
Marijuana Dependence Behavioral: Reinforcement for homework completion Behavioral: Reinforcement for Abstinence Behavioral: Case Management Not Applicable

Detailed Description:
Participants will receive an intervention combining one session of motivational enhancement therapy with eight sessions of cognitive-behavioral coping skills therapy (MET+CBT). A contingency management procedure will be added to this intervention, providing reinforcement for completion of homework, as verified by call-ins to an Interactive Voice Recording (IVR) system. Outcomes will be compared to an MET+CBT intervention in which reinforcement will be provided for marijuana-free urine specimens, and to a control group that receives Case Management. Recruitment of 234 marijuana-dependent participants will occur over a three-year period. They will be randomly assigned to one of the three 9-session interventions. Treatment will be individual, manualized, and provided on an outpatient basis. Pretreatment assessments will obtain baseline data; follow-up assessments at three-month intervals for one year will evaluate marijuana use outcomes, other drug or alcohol use, and psychosocial functioning. It is anticipated that the intervention in which completion of homework is reinforced will result in the best outcomes. The mechanisms by which the interventions result in behavior change will be the specific focus of attention in this study.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 215 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Contingency Management for Marijuana Dependence
Study Start Date : February 2007
Actual Primary Completion Date : April 2011
Actual Study Completion Date : August 2012

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Marijuana

Arm Intervention/treatment
Experimental: Reinforcement for homework completion Behavioral: Reinforcement for homework completion
Provides contingent reinforcement for engaging in homework activities designed to enhance coping skills

Active Comparator: Reinforcement for Abstinence Behavioral: Reinforcement for Abstinence
Provides contingent reinforcement for submitting marijuana-free urine specimen

Active Comparator: Case Management Behavioral: Case Management
Will control for the effect of therapist-client contact by providing supportive case management as an active control condition.

Primary Outcome Measures :
  1. Marijuana abstinence [ Time Frame: One-year follow-up period ]
  2. Self-efficacy, use of coping skills, and treatment attendance [ Time Frame: During 2-month treatment period ]

Secondary Outcome Measures :
  1. Continuous abstinence will be predicted by (a) treatment attendance; (b) posttreatment self-efficacy for coping; and (c) use of coping skills [ Time Frame: One-year follow-up period ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Cannabis dependence
  • Willing to accept random assignment to interventions

Exclusion Criteria:

  • Current dependence on alcohol or other drugs
  • Problems that require inpatient hospitalization
  • Reading ability below fifth grade level
  • Lack of reliable transportation to treatment
  • Excessive commuting distance

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00107588

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United States, Connecticut
University of Connecticut Health Center
Farmington, Connecticut, United States, 06030-3910
Sponsors and Collaborators
UConn Health
National Institute on Drug Abuse (NIDA)
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Principal Investigator: Mark D Litt, Ph.D. UConn Health

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Responsible Party: Mark Litt, Professor, UConn Health Identifier: NCT00107588    
Other Study ID Numbers: NIDA-12728-06
R01DA012728-06 ( U.S. NIH Grant/Contract )
First Posted: April 6, 2005    Key Record Dates
Last Update Posted: July 28, 2017
Last Verified: July 2017
Keywords provided by Mark Litt, UConn Health:
marijuana dependence
coping skills
marijuana abstinence
Additional relevant MeSH terms:
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Marijuana Abuse
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders