Genetic Registry for Rheumatoid Arthritis (NARAC)

This study has been completed.
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Arthritis Foundation
Information provided by (Responsible Party):
Peter Gregersen, North Shore Long Island Jewish Health System Identifier:
First received: September 25, 2003
Last updated: September 9, 2015
Last verified: September 2015
Many genes are thought to contribute to rheumatoid arthritis (RA). This study will attempt to identify genes that may contribute to RA.

Rheumatoid Arthritis

Study Type: Observational
Study Design: Observational Model: Family-Based
Time Perspective: Cross-Sectional
Official Title: Genetics of Rheumatoid Arthritis Registry

Resource links provided by NLM:

Further study details as provided by North Shore Long Island Jewish Health System:

Primary Outcome Measures:
  • Genetic Association with risk for rheumatoid arthritis [ Time Frame: 10 years ] [ Designated as safety issue: No ]
    The project aims to identify risk alleles for rheumatoid arthritis using association methods in trio families, combined with data from singleton cases and multiplex families

Biospecimen Retention:   Samples With DNA
DNA, plasma, serum and cells

Enrollment: 1062
Study Start Date: October 2002
Study Completion Date: August 2015
Primary Completion Date: August 2015 (Final data collection date for primary outcome measure)
Detailed Description:

The identification of genes for complex disorders such as RA requires large numbers of genetically informative families. This study enrolls people diagnosed with with RA and their families.

This study will enroll 1000 RA patients and their parents. Participants with RA will be evaluated at his or her doctor's office or other location convenient for the participant. Participants will have a brief phone interview with a study coordinator and a blood sample will be obtained. Disease evaluation will be done at one visit and will include confirmation of diagnosis, a 28 joint count, joint alignment and mobility score (JAMS) and administration of a health assessment questionnaire.


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Persons with RA who have two living biological parents. Parents can be affected or unaffected with RA. We call the family units "trios".

Inclusion Criteria:

  • Adult onset RA
  • Diagnosis of RA made between 18 and 60 years old
  • Both parents alive and willing to participate
  • Parents may have diagnosis of RA (affected) or be unaffected

Exclusion Criteria:

  • Inflammatory bowel disease
  • Lupus
  • Psoriatic arthritis
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00069472

United States, New York
Feinstein Institute for Medical Research
Manhasset, New York, United States, 11030
Sponsors and Collaborators
North Shore Long Island Jewish Health System
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Arthritis Foundation
Principal Investigator: Peter K. Gregersen, MD North Shore University Hospital
  More Information


Responsible Party: Peter Gregersen, Center Head, Robert S Boas Center for Genomics and Human Genetics, North Shore Long Island Jewish Health System Identifier: NCT00069472     History of Changes
Other Study ID Numbers: NIAMS-107, N01AR72232-001
Study First Received: September 25, 2003
Last Updated: September 9, 2015
Health Authority: United States: Federal Government

Keywords provided by North Shore Long Island Jewish Health System:

Additional relevant MeSH terms:
Arthritis, Rheumatoid
Autoimmune Diseases
Connective Tissue Diseases
Immune System Diseases
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases processed this record on November 27, 2015