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Characteristics of Weaning From Mechanical Ventilation in COVID-19 (CovWean)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT05049200
Recruitment Status : Completed
First Posted : September 20, 2021
Last Update Posted : November 1, 2021
Information provided by (Responsible Party):
Matias Accoce, Sanatorio Anchorena San Martin

Brief Summary:
This report is a multicenter, observational, analytical and prospective study. The objective was to describe the weaning of mechanical ventilation in patients with SARS-CoV-2 and the clinical results according to the different types of weaning.

Condition or disease
Respiration, Artificial COVID-19

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Study Type : Observational [Patient Registry]
Actual Enrollment : 326 participants
Observational Model: Cohort
Time Perspective: Prospective
Target Follow-Up Duration: 5 Months
Official Title: Epidemiology of Weaning From Invasive Mechanical Ventilation in COVID-19. Observational and Multicenter Study.
Actual Study Start Date : April 1, 2020
Actual Primary Completion Date : August 31, 2020
Actual Study Completion Date : October 1, 2020

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. weaning rate [ Time Frame: on day 28 ]
    percentage of successfully weaned patients

  2. weaning classification [ Time Frame: on day 28 ]
    number of spontaneous breathing tests and days from first spontaneous breathing test to success or death

Secondary Outcome Measures :
  1. mechanical ventilation days [ Time Frame: on day 28 ]
    duration of invasive mechanical ventilation

  2. length of ICU stay [ Time Frame: on day 28 ]
    days of hospitalization in ICU

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with a diagnosis of COVID-19 by PCR + and who required invasive mechanical ventilation for more than 12 hours were included.

Inclusion Criteria:

  • Diagnosis of COVID-19 by PCR +
  • Invasive mechanical ventilation for more than 12 hours

Exclusion Criteria:

  • Subjects admitted to pediatric ICUs and surgery recovery room.
  • Patients who were readmitted and required a new cycle of invasive mechanical ventilation after having been successfully weaned and released from the hospital.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT05049200

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Matias Accoce
Pereyra, Buenos Aires, Argentina, 1894
Sanatorio Anchorena de San Martin
San Martín, Buenos Aires, Argentina, B1650CQU
Sponsors and Collaborators
Sanatorio Anchorena San Martin
Publications of Results:

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Responsible Party: Matias Accoce, HEAD OF RESPIRATORY THERAPY, Sanatorio Anchorena San Martin
ClinicalTrials.gov Identifier: NCT05049200    
Other Study ID Numbers: 15/16
First Posted: September 20, 2021    Key Record Dates
Last Update Posted: November 1, 2021
Last Verified: October 2021

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Matias Accoce, Sanatorio Anchorena San Martin:
Respiration, Artificial
Ventilator Weaning
Airway Extubation
Additional relevant MeSH terms:
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Respiratory Tract Infections
Pneumonia, Viral
Virus Diseases
Coronavirus Infections
Coronaviridae Infections
Nidovirales Infections
RNA Virus Infections
Lung Diseases
Respiratory Tract Diseases