Serological Response to mRNA and Inactivated COVID-19 Vaccine in Health Care Workers in Hong Kong
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT04898946|
Recruitment Status : Recruiting
First Posted : May 24, 2021
Last Update Posted : June 1, 2021
Since the first local case of COVID-19 confirmed on 4 Feb 2020, Hong Kong has already experienced 4 waves of COVID-19 surge, with more than 9000 cases reported. A number of vaccines have been shown to be efficacious against symptomatic and severe infection by inducing neutralizing antibody (NAB) against spike protein of the SARS-CoV-2 virus. However, the duration of protection and longevity of antibody response is unknown.
Health care workers (HCWs) who are planning to receive COVID-19 vaccine will be recruited. The level of antibody against spike protein by different quantitative assays will also be serially measured .
|Condition or disease||Intervention/treatment|
|Covid-19 Vaccine||Biological: CoronaVac Vaccine Biological: BNT162b2 Vaccine|
|Study Type :||Observational|
|Estimated Enrollment :||400 participants|
|Official Title:||Serological Response to mRNA and Inactivated COVID-19 Vaccine in Health Care Workers in Hong Kong|
|Actual Study Start Date :||March 8, 2021|
|Estimated Primary Completion Date :||March 8, 2022|
|Estimated Study Completion Date :||March 8, 2022|
Subjects who receive mRNA vaccine BNT162b2.
Biological: BNT162b2 Vaccine
Covid-19 BNT162b2 Vaccine
Subjects who receive inactivated vaccine, CoronaVac.
Biological: CoronaVac Vaccine
- Change of IgG Level in the serum of healthcare workers who received COVID-19 vaccine [ Time Frame: 1 month, 3 months and 6 months post vaccination ]Change of IgG Level in the serum of healthcare workers who received COVID-19 vaccine at different points during the first six months of vaccination
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04898946
|Contact: Jonpaul Sze Tsing Zee, MBChB||28357064||Jonpaul.ST.Zee@hksh.com|
|Contact: Lam Fung Kwok, BscNursing||28357195||LamFung.Kwok@hksh.com|
|Hong Kong Sanatorium & Hospital||Recruiting|
|Hong Kong, Hong Kong|
|Contact: Jonpaul Sze Tsing Zee, MBChB 28357064 email@example.com|