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Study on Susceptibility Genes and Pathogenic Mechanism of Non-syndromic Familial Aortic Dissection

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT04439565
Recruitment Status : Recruiting
First Posted : June 19, 2020
Last Update Posted : June 19, 2020
Sponsor:
Information provided by (Responsible Party):
Zaiping Jing, Chinese Medical Association

Study Description
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Brief Summary:
Aortic dissection is dangerous and difficult to predict, so it is particularly important to carry out early prevention, diagnosis and rational treatment for high-risk groups. The related genes found in previous studies can not be detected in all patients with dissection; at present, the pathogenesis of non-syndromic aortic dissection is not clear, of which about 20% of patients have family aggregation and have the general representative characteristics of non-syndromic dissection. In this project, the peripheral blood samples of core family subjects were detected by sequencing technique. analyze disease-related susceptibility genes; 2 determine the effect of susceptibility genes on the incidence of dissection in mice through animal experiments; and 3 explore the effect of susceptibility genes on cell function at the cellular level.

Condition or disease Intervention/treatment
Aortic Dissection Family Research Aortic Dissection, Familial, With or Without Aortic Aneurysm Genetic: movement

Study Design
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Study Type : Observational
Estimated Enrollment : 100 participants
Observational Model: Family-Based
Time Perspective: Other
Official Title: Study on Susceptibility Genes and Pathogenic Mechanism of Non-syndromic Familial Aortic Dissection
Estimated Study Start Date : June 17, 2020
Estimated Primary Completion Date : June 17, 2023
Estimated Study Completion Date : July 17, 2023

Resource links provided by the National Library of Medicine


Groups and Cohorts
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Intervention Details:
  • Genetic: movement
    aortic dissection or aneurysm patients this is an observation cohort study about a Non-syndromic Familial Aortic Dissection without intervention.

Outcome Measures
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Primary Outcome Measures :
  1. gege [ Time Frame: 2023 ]
    Discovery of known or unknown genes


Biospecimen Retention:   Samples With DNA
DNA is extracted from blood and preserved for a long time.

Eligibility Criteria
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Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
1, family members have no traumatic aortic dissection; 2, no pregnancy or tumor.
Criteria

Inclusion Criteria:

  • Family inclusion criteria: 1 at least one person in each generation of a family has aortic dissection, and at least two generations of members can be included;

Exclusion Criteria:

  • Pedigree exclusion criteria: pedigree members have marfan syndrome, Loeys-Dietz syndrome, Ehler-Danlos syndrome, aneurysm-Osteoarthritis syndrome and other syndroms
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04439565


Contacts
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Contact: Jing Zaiping, professor 02131161670 xueguanky@163.com

Locations
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China, Shanghai
Changhaihospital Recruiting
Shanghai, Shanghai, China, 200433
Contact: Jing Zaiping, MD    61670    xueguanky@163.com   
Sponsors and Collaborators
Chinese Medical Association
More Information
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Responsible Party: Zaiping Jing, professor, Chinese Medical Association
ClinicalTrials.gov Identifier: NCT04439565    
Other Study ID Numbers: https://orcid.org/0000-0002-05
First Posted: June 19, 2020    Key Record Dates
Last Update Posted: June 19, 2020
Last Verified: June 2020
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Zaiping Jing, Chinese Medical Association:
aortic dissection
pathogenesis
familial inheritance
susceptibility gene
Additional relevant MeSH terms:
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Aneurysm
Aortic Aneurysm
Aneurysm, Dissecting
Disease Susceptibility
Vascular Diseases
 Cardiovascular Diseases
Aortic Diseases
Disease Attributes
Pathologic Processes