Review of Isolated Hypoganglionosis and Presentation of a New Case Complicated With Sigmoid Volvulus
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT04363125|
Recruitment Status : Completed
First Posted : April 27, 2020
Last Update Posted : April 28, 2020
|Condition or disease||Intervention/treatment|
|Pathology Sigmoid Volvulus Hypoganglionosis||Diagnostic Test: Pathology result|
Isolated hypoganglionosis is rare and constitutes 3-5% of all congenital neurological bowel diseases. Since hypoganglionosis is associated with symptoms such as chronic constipation or pseudo-obstruction, it can be confused with Hirschprung's disease and it is important to make a differential diagnosis before treatment. Our aim in this study; In addition to sharing the rarely isolated hypoganglionosis and sigmoid volvulus in a 45-year-old male patient with mental retardation, the investigators present a systematic comprehensive review of hypoganglionosis. Pubmed and Scopus databases were scanned. No restrictions were used in the written language. Only isolated cases of hypoganglionosis were added to the study. In the cases; author, year of publication, country of publication, age, gender, surgical or non-surgical treatments, treatment results, and mortalities were examined.
When sigmoid volvulus is seen in children and adolescents, congenital neurological bowel diseases should be considered in the differential diagnosis. Hirschprung's disease must be ruled out by rectal biopsy. The histopathological investigation should be carried out for the diagnosis and determination of surgical margins in isolated hypoganglionosis.
|Study Type :||Observational|
|Actual Enrollment :||310 participants|
|Official Title:||Systematic Review of Isolated Hypoganglionosis and Presentation of a New Case Complicated With Sigmoid Volvulus|
|Actual Study Start Date :||January 1, 2019|
|Actual Primary Completion Date :||April 1, 2020|
|Actual Study Completion Date :||April 20, 2020|
- Diagnostic Test: Pathology result
Pathology result of rectal biopsy
- Mortality [ Time Frame: three months ]Mortality of sigmoid volvulus due to isolated hypoganglionosis
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04363125
|Dr. Ersin Arslan Training and Resource Hospital|
|Principal Investigator:||ufuk uylas, Specialist||Dr. Ersin Arslan Training and Resource Hospital|